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Sökning: WFRF:(Tamura Rodrigo Esaki) > (2023) > Lysicamine Reduces ...

Lysicamine Reduces Protein Kinase B (AKT) Activation and Promotes Necrosis in Anaplastic Thyroid Cancer

Rodrigues, Mariana Teixeira (författare)
Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
Michelli, Ana Paula Picaro (författare)
Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
Caso, Gustavo Felisola (författare)
Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
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de Oliveira, Paloma Ramos (författare)
Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
Mendes Rodrigues Junior, Dorival (författare)
Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Uppsala Univ, Biomed Ctr, Dept Med Biochem & Microbiol, Sci Life Lab, S-75236 Uppsala, Sweden.
Morale, Mirian Galliote (författare)
Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.
Machado Junior, Joel (författare)
Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.
Bortoluci, Karina Ramalho (författare)
Univ Fed Sao Paulo UNIFESP, Pharmacol Dept, Escola Paulista Med, BR-04021001 Sao Paulo, Brazil.
Tamura, Rodrigo Esaki (författare)
Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.;Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Biol Chem Postgrad Program, BR-09920000 Diadema, Brazil.
da Silva, Tamiris Reissa Cipriano (författare)
Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Chem, BR-09920000 Diadema, Brazil.
Raminelli, Cristiano (författare)
Univ Fed Sao Paulo UNIFESP, Inst Environm Chem & Pharmaceut Sci, Dept Chem, BR-09920000 Diadema, Brazil.
Chau, Eric (författare)
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA.
Godin, Biana (författare)
Houston Methodist Res Inst, Dept Nanomed, Houston, TX 77030 USA.;Weill Cornell Med Coll, Dept Obstet & Gynecol, New York, NY 10065 USA.
Calil-Silveira, Jamile (författare)
Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Nove de Julho, Hlth Board 3, BR-01525000 Sao Paulo, Brazil.
Rubio, Ileana G. Sanchez (författare)
Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Biol Sci Dept, BR-09920000 Diadema, Brazil.
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Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil;Univ Fed Sao Paulo UNIFESP, Struct & Funct Biol Postgrad Program, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil. Univ Fed Sao Paulo UNIFESP, Thyroid Mol Sci Lab, BR-04021001 Sao Paulo, Brazil.;Univ Fed Sao Paulo UNIFESP, Canc Mol Biol Lab, BR-04021001 Sao Paulo, Brazil. (creator_code:org_t)
MDPI, 2023
2023
Engelska.
Ingår i: Pharmaceuticals. - : MDPI. - 1424-8247. ; 16:12
Relaterad länk:
https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
https://urn.kb.se/re...
https://doi.org/10.3...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Anaplastic thyroid cancer (ATC) is an aggressive form of thyroid cancer (TC), accounting for 50% of total TC-related deaths. Although therapeutic approaches against TC have improved in recent years, the survival rate remains low, and severe adverse effects are commonly reported. However, unexplored alternatives based on natural compounds, such as lysicamine, an alkaloid found in plants with established cytotoxicity against breast and liver cancers, offer promise. Therefore, this study aimed to explore the antineoplastic effects of lysicamine in papillary TC (BCPAP) and ATC (HTH83 and KTC-2) cells. Lysicamine treatment reduced cell viability, motility, colony formation, and AKT activation while increasing the percentage of necrotic cells. The absence of caspase activity confirmed apoptosis-independent cell death. Necrostatin-1 (NEC-1)-mediated necrosome inhibition reduced lysicamine-induced necrosis in KTC-2, suggesting necroptosis induction via a reactive oxygen species (ROS)-independent mechanism. Additionally, in silico analysis predicted lysicamine target proteins, particularly those related to MAPK and TGF-beta signaling. Our study demonstrated lysicamine's potential as an antineoplastic compound in ATC cells with a proposed mechanism related to inhibiting AKT activation and inducing cell death.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

Nyckelord

thyroid cancer
anaplastic thyroid cancer
lysicamine
natural compounds
necrosis
akt phosphorylation

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