| 1. |
- Arking, D. E., et al.
(författare)
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Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization
- 2014
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Ingår i: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 46:8, s. 826-836
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritable trait. QT prolongation is a risk factor for ventricular arrhythmias and sudden cardiac death (SCD) and could indicate the presence of the potentially lethal mendelian long-QT syndrome (LQTS). Using a genome-wide association and replication study in up to 100,000 individuals, we identified 35 common variant loci associated with QT interval that collectively explain ∼ 8-10% of QT-interval variation and highlight the importance of calcium regulation in myocardial repolarization. Rare variant analysis of 6 new QT interval-associated loci in 298 unrelated probands with LQTS identified coding variants not found in controls but of uncertain causality and therefore requiring validation. Several newly identified loci encode proteins that physically interact with other recognized repolarization proteins. Our integration of common variant association, expression and orthogonal protein-protein interaction screens provides new insights into cardiac electrophysiology and identifies new candidate genes for ventricular arrhythmias, LQTS and SCD. © 2014 Nature America, Inc.
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| 2. |
- Grieser, M., et al.
(författare)
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Storage ring at HIE-ISOLDE Technical design report
- 2012
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Ingår i: The European Physical Journal Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 207:1, s. 1-117
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Forskningsöversikt (refereegranskat)abstract
- We propose to install a storage ring at an ISOL-type radioactive beam facility for the first time. Specifically, we intend to setup the heavy-ion, low-energy ring TSR at the HIE-ISOLDE facility in CERN, Geneva. Such a facility will provide a capability for experiments with stored secondary beams that is unique in the world. The envisaged physics programme is rich and varied, spanning from investigations of nuclear ground-state properties and reaction studies of astrophysical relevance, to investigations with highly-charged ions and pure isomeric beams. The TSR might also be employed for removal of isobaric contaminants from stored ion beams and for systematic studies within the neutrino beam programme. In addition to experiments performed using beams recirculating within the ring, cooled beams can also be extracted and exploited by external spectrometers for high-precision measurements. The existing TSR, which is presently in operation at the Max-Planck Institute for Nuclear Physics in Heidelberg, is well-suited and can be employed for this purpose. The physics cases as well as technical details of the existing ring facility and of the beam and infrastructure requirements at HIE-ISOLDE are discussed in the present technical design report.
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| 3. |
- Grieser, M., et al.
(författare)
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Storage ring at HIE-ISOLDE
- 2012
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Ingår i: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6401 .- 1951-6355. ; 207:1, s. 1-117
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Tidskriftsartikel (refereegranskat)abstract
- We propose to install a storage ring at an ISOL-type radioactive beam facility for the first time. Specifically, we intend to setup the heavy-ion, low-energy ring TSR at the HIE-ISOLDE facility in CERN, Geneva. Such a facility will provide a capability for experiments with stored secondary beams that is unique in the world. The envisaged physics programme is rich and varied, spanning from investigations of nuclear ground-state properties and reaction studies of astrophysical relevance, to investigations with highly-charged ions and pure isomeric beams. The TSR might also be employed for removal of isobaric contaminants from stored ion beams and for systematic studies within the neutrino beam programme. In addition to experiments performed using beams recirculating within the ring, cooled beams can also be extracted and exploited by external spectrometers for high-precision measurements. The existing TSR, which is presently in operation at the Max-Planck Institute for Nuclear Physics in Heidelberg, is well-suited and can be employed for this purpose. The physics cases as well as technical details of the existing ring facility and of the beam and infrastructure requirements at HIE-ISOLDE are discussed in the present technical design report.
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| 4. |
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| 5. |
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| 6. |
- Fomichev, A. S., et al.
(författare)
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Status of the ACCULINNA-2 project at FLNR
- 2012
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Ingår i: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6588 .- 1742-6596. ; 337:1, s. Art. no. 012025-
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Konferensbidrag (refereegranskat)abstract
- The project of a new and more powerful in-flight fragment separator ACCULINNA-2 at U-400M cyclotron in FLNR, JINR planned to build in addition to the existing separator ACCULINNA is presented. The new separator will provide high intensity RIBs in the lowest energy range (5÷50 MeV/nucleon) which is attainable for in-flight separators. The possibilities for the astrophysics studies at the proposed device are presented. ACCULINNA-2 separator is planned to be constructed in the years 2010-2015. The current status of the project is reported.
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| 7. |
- Fomichev, A. S., et al.
(författare)
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Long range plan with radioactive beams at Dubna
- 2010
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Ingår i: 3rd International Conference on Current Problems in Nuclear Physics and Atomic Energy, NPAE 2010; Kyiv; Ukraine; 7 June 2010 through 12 June 2010. ; , s. 64-69
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Konferensbidrag (refereegranskat)abstract
- A program for upgrade of existing radioactive ion beams facilities at Flerov Laboratory of Nuclear Reactions, JINR Dubna is presented. A project of a new in-flight fragment separator ACCULINNA-2 is proposed. It is expected the new instrument will be more universal and powerful than the existing nowadays. The beam intensity should be increased by factor 10-15, its optical quality greatly improved and the range of the accessible secondary radioactive beams broadened up to Z∼20. Main ion-optical characteristics, operating principles and a tentative plan for the project realization are included. An extensive research program based on local experiments made so far and international proposals for these equipments is discussed.
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| 8. |
- Fomichev, A. S., et al.
(författare)
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The Suggested New Fragment Separator ACCULINNA-2
- 2010
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Ingår i: Acta Physica Polonica, Series B.. - 1509-5770 .- 0587-4254. ; 41:2, s. 475-480
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Tidskriftsartikel (refereegranskat)abstract
- We present new project of fragment separator ACCULINNA-2 that is being planned to be constructed in Flerov Laboratory of Nuclear Reaction, JINR. The ACCULINNA-2 facility is not, intended to compete with the, new large in-flight RIB facilities. It, should complement the existing/constructed facilities in certain fields. Namely, ACCULINNA-2 should provide high intensity RIBs in the lowest energy range attainable for in-flight separators.
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| 9. |
- Krupko, S. A., et al.
(författare)
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Fragment separator ACCULINNA-2
- 2010
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Ingår i: AIP Conference Proceedings. - : AIP. - 1551-7616 .- 0094-243X. - 9780735407688 ; 1224, s. 516-521
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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| 10. |
- Tarasov, P. E., et al.
(författare)
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A pollen-based biome reconstruction over the last 3.562 million years in the Far East Russian Arctic - new insights into climate-vegetation relationships at the regional scale
- 2013
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Ingår i: Climate of the Past. - : Copernicus GmbH. - 1814-9332. ; 9:6, s. 2759-2775
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Tidskriftsartikel (refereegranskat)abstract
- The recent and fossil pollen data obtained under the frame of the multi-disciplinary international El'gygytgyn Drilling Project represent a unique archive, which allows the testing of a range of pollen-based reconstruction approaches and the deciphering of changes in the regional vegetation and climate. In the current study we provide details of the biome reconstruction method applied to the late Pliocene and Quaternary pollen records from Lake El'gygytgyn. All terrestrial pollen taxa identified in the spectra from Lake El'gygytgyn were assigned to major vegetation types (biomes), which today occur near the lake and in the broader region of eastern and northern Asia and, thus, could be potentially present in this region during the past. When applied to the pollen spectra from the middle Pleistocene to present, the method suggests (1) a predominance of tundra during the Holocene, (2) a short interval during the marine isotope stage (MIS) 5.5 interglacial distinguished by cold deciduous forest, and (3) long phases of taiga dominance during MIS 31 and, particularly, MIS 11.3. These two latter interglacials seem to be some of the longest and warmest intervals in the study region within the past million years. During the late Pliocene-early Pleistocene interval (i.e., similar to 3.562-2.200 Ma), there is good correspondence between the millennial-scale vegetation changes documented in the Lake El'gygytgyn record and the alternation of cold and warm marine isotope stages, which reflect changes in the global ice volume and sea level. The biome reconstruction demonstrates changes in the regional vegetation from generally warmer/wetter environments of the earlier (i. e., Pliocene) interval towards colder/drier environments of the Pleistocene. The reconstruction indicates that the taxon-rich cool mixed and cool conifer forest biomes are mostly characteristic of the time prior to MIS G16, whereas the tundra biome becomes a prominent feature starting from MIS G6. These results consistently indicate that the study region supported significant tree populations during most of the interval prior to similar to 2.730 Ma. The cold-and drought-tolerant steppe biome first appears in the reconstruction similar to 3.298 Ma during the tundra-dominated MIS M2, whereas the tundra biome initially occurs between similar to 3.379 and similar to 3.378 Ma within MIS MG4. Prior to similar to 2.800 Ma, several other cold stages during this generally warm Pliocene interval were characterized by the tundra biome.
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