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Träfflista för sökning "WFRF:(Telford Richard J.) srt2:(2006-2009)"

Sökning: WFRF:(Telford Richard J.) > (2006-2009)

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1.
  • Antonsson, Karin, et al. (författare)
  • Quantitative palaeotemperature records inferred from fossil pollen and chironomid assemblages from Lake Gilltjärnen, northern central Sweden
  • 2006
  • Ingår i: Journal of Quaternary Science. - : Wiley. - 0267-8179 .- 1099-1417. ; 21:8, s. 831-841
  • Tidskriftsartikel (refereegranskat)abstract
    • Palaeotemperature reconstructions based on radiocarbon-dated fossil pollen and chironomid stratigraphies obtained from Lake Gilltjarnen provide evidence of climate changes during the last 11 000 years in the boreal zone of northern central Sweden. The records show consistent trends during the early and mid-Holocene, indicating low temperatures at 11 000-10 000 cal. yr BP, followed by a rising trend and a period of maximum values from about 7000 to 4000 cal. yr BP. At 3000 cal. yrBP the chironomid-inferred temperature values rise abruptly, deviating from the late-Holocene cooling trend indicated by the pollen-based reconstruction and most of the other palaeotemperature records from central Scandinavia, probably as a result of local limnological changes in Lake Gilltjarnen and its catchment. Comparison of the present results with a lake-level reconstruction from Lake Ljustjarnen, ca. 100 km southwest of Lake Gilitjarnen, shows that the low early-Holocene temperatures were associated with high lake-levels at 10500-8500 cal. yrBP, whereas low lake-levels and dry conditions prevailed during the period of high temperatures at between 7500 and 5000 cal. yr BP, probably due to high summer evapotranspiration and lower precipitation.
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2.
  • Ali, Hassan, et al. (författare)
  • Vibrational spectroscopic characterisation of salmeterol xinafoate polymorphs and a preliminary investigation of their transformation using simultaneous in situ portable Raman spectroscopy and differential scanning calorimetry
  • 2008
  • Ingår i: Analytica Chimica Acta. - : Elsevier BV. - 0003-2670 .- 1873-4324. ; 620:1-2, s. 103-12
  • Tidskriftsartikel (refereegranskat)abstract
    • Knowledge and control of the polymorphic phases of chemical compounds are important aspects of drug development in the pharmaceutical industry. Salmeterol xinafoate, a long acting beta-adrenergic receptor agonist, exists in two polymorphic Forms, I and II. Raman and near infrared spectra were obtained of these polymorphs at selected wavelengths in the range of 488-1064 nm; significant differences in the Raman and near-infrared spectra were apparent and key spectral marker bands have been identified for the vibrational spectroscopic characterisation of the individual polymorphs which were also characterised with X ray diffractometry. The solid-state transition of salmeterol xinafoate polymorphs was studied using simultaneous in situ portable Raman spectroscopy and differential scanning calorimetry isothermally between transitions. This method assisted in the unambiguous characterisation of the two polymorphic forms by providing a simultaneous probe of both the thermal and vibrational data. The study demonstrates the value of a rapid in situ analysis of a drug polymorph which can be of potential value for at-line in-process control
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