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Sökning: WFRF:(Tell A.) > (2010-2014)

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1.
  • Purdue, Mark P, et al. (författare)
  • Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
  • 2011
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 43:1, s. 60-65
  • Tidskriftsartikel (refereegranskat)abstract
    • We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to EPAS1 on 2p21, which encodes hypoxia-inducible-factor-2 alpha, a transcription factor previously implicated in RCC. The second locus, rs7105934, at 11q13.3, contains no characterized genes (P = 7.8 × 10⁻¹⁴). In addition, we observed a promising association on 12q24.31 for rs4765623, which maps to SCARB1, the scavenger receptor class B, member 1 gene (P = 2.6 × 10⁻⁸). Our study reports previously unidentified genomic regions associated with RCC risk that may lead to new etiological insights.
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3.
  • Wu, Di, et al. (författare)
  • System architecture for 3GPP-LTE modem using a programmable baseband processor
  • 2010
  • Ingår i: International Journal of Embedded and Real-Time Communication Systems. - : IGI Global. - 1947-3176 .- 1947-3184. ; 1:3, s. 44-64
  • Tidskriftsartikel (refereegranskat)abstract
    • The evolution of third generation mobile communications toward high-speed packet access and long-term evolution is ongoing and will substantially increase the throughput with higher spectral efficiency. This paper presents the system architecture of an LTE modem based on a programmable baseband processor. The architecture includes a baseband processor that handles processing time and frequency synchronization, IFFT/FFT (up to 2048-p), channel estimation and subcarrier de-mapping. The throughput and latency requirements of a Category four User Equipment (CAT4 UE) is met by adding a MIMO symbol detector and a parallel Turbo decoder supporting H-ARQ, which brings both low silicon cost and enough flexibility to support other wireless standards. The complexity demonstrated by the modem shows the practicality and advantage of using programmable baseband processors for a single-chip LTE solution. Copyright © 2010, IGI Global.
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