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Chromosomal Abnorma...
Chromosomal Abnormalities and Prognosis in NPM1-Mutated Acute Myeloid Leukemia : A Pooled Analysis of Individual Patient Data From Nine International Cohorts
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- Angenendt, Linus (författare)
- Univ Hosp Munster, Munster, Germany,University Hospital Münster
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- Röllig, Christoph (författare)
- Tech Univ Dresden, Univ Hosp, Dresden, Germany,University Clinic Carl Gustav Carus at the TU Dresden
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- Montesinos, Pau (författare)
- Hosp Univ & Politec La Fe, Valencia, Spain;Ctr Invest Biomed Red Canc, Madrid, Spain,University and Polytechnic Hospital la Fe
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visa fler...
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- Martinez-Cuadron, David (författare)
- Hosp Univ & Politec La Fe, Valencia, Spain;Ctr Invest Biomed Red Canc, Madrid, Spain,University and Polytechnic Hospital la Fe
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- Barragan, Eva (författare)
- Hosp Univ & Politec La Fe, Valencia, Spain;Ctr Invest Biomed Red Canc, Madrid, Spain,University and Polytechnic Hospital la Fe
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- Garcia, Raimundo (författare)
- Gen Hosp Castellon, Castellon de La Plana, Spain,General Hospital Castellón
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- Botella, Carmen (författare)
- Hosp Gen Alicante, Alicante, Spain,Alicante University General Hospital
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- Martinez, Pilar (författare)
- Hosp 12 Octubre, Madrid, Spain,12 de Octubre University Hospital
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- Ravandi, Farhad (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA,University of Texas
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- Kadia, Tapan (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA,University of Texas
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- Kantarjian, Hagop M. (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA,University of Texas
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- Cortes, Jorge (författare)
- Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA,University of Texas
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- Juliusson, Gunnar (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Lazarevic, Vladimir (författare)
- Lund University,Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine
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- Höglund, Martin (författare)
- Uppsala universitet,Hematologi
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- Lehmann, Sören (författare)
- Karolinska Institutet,Uppsala universitet,Hematologi
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- Recher, Christian (författare)
- CHU Toulouse, Toulouse, France,Toulouse University Hospital
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- Pigneux, Arnaud (författare)
- CHU Bordeaux, Hop Haut Leveque, Bordeaux, France,Hopital Haut-Leveque C.H.U de Bordeaux
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- Bertoli, Sarah (författare)
- CHU Toulouse, Toulouse, France,Toulouse University Hospital
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- Dumas, Pierre-Yves (författare)
- CHU Bordeaux, Hop Haut Leveque, Bordeaux, France,Hopital Haut-Leveque C.H.U de Bordeaux
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- Dombret, Herve (författare)
- Paris Diderot Univ, Paris, France,Paris Diderot University
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- Preudhomme, Claude (författare)
- Inst Natl Sante & Rech Med Lille, Lille, France,Institut Gustave Roussy
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- Micol, Jean-Baptiste (författare)
- Paris Saclay Univ, Gustave Roussy, Villejuif, France,University of Paris-Saclay
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- Terre, Christine (författare)
- Ctr Transfus Sanguine, Le Chesnay, France,Centre de Transfusion Sanguine
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- Racil, Zdenek (författare)
- Masaryk Univ, Univ Hosp Brno, Brno, Czech Republic,University Hospital Brno
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- Novak, Jan (författare)
- Charles Univ Prague, Univ Hosp Kralovske Vinohrady, Fac Med 3, Prague, Czech Republic,University Hospital Kralovske Vinohrady
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- Zak, Pavel (författare)
- Charles Univ Prague, Univ Hosp Hradec Kralove, Hradec Kralove, Czech Republic,University Hospital Hradec Kralove
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- Wei, Andrew H. (författare)
- Monash Univ, Alfred Hosp, Melbourne, Vic, Australia,Monash University
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- Tiong, Ing S. (författare)
- Monash Univ, Alfred Hosp, Melbourne, Vic, Australia,Monash University
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- Wall, Meaghan (författare)
- St Vincents Hosp, Melbourne, Vic, Australia,St. Vincent's Hospital, Melbourne
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- Estey, Elihu (författare)
- Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA,University of Washington,University Hospital Münster
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- Shaw, Carole (författare)
- Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA,University of Washington
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- Exeler, Rita (författare)
- Univ Munster, Munster, Germany,University of Münster
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- Wagenführ, Lisa (författare)
- Tech Univ Dresden, Univ Hosp, Dresden, Germany,Medizinsche Klinik und Poliklinik I, Dresden
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- Stölzel, Friedrich (författare)
- Tech Univ Dresden, Univ Hosp, Dresden, Germany,Medizinsche Klinik und Poliklinik I, Dresden
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- Thiede, Christian (författare)
- Tech Univ Dresden, Univ Hosp, Dresden, Germany,Medizinsche Klinik und Poliklinik I, Dresden
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- Stelljes, Matthias (författare)
- Univ Hosp Munster, Munster, Germany,University Hospital Münster
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- Lenz, Georg (författare)
- Univ Hosp Munster, Munster, Germany,University Hospital Münster
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- Mikesch, Jan-Henrik (författare)
- Univ Hosp Munster, Munster, Germany,University Hospital Münster
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- Serve, Hubert (författare)
- Univ Hosp Frankfurt, Frankfurt, Germany,University Hospital Frankfurt
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- Ehninger, Gerhard (författare)
- Tech Univ Dresden, Univ Hosp, Dresden, Germany,Medizinsche Klinik und Poliklinik I, Dresden
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- Berdel, Wolfgang E. (författare)
- Univ Hosp Munster, Munster, Germany
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- Kramer, Michael (författare)
- Tech Univ Dresden, Univ Hosp, Dresden, Germany,Medizinsche Klinik und Poliklinik I, Dresden
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- Krug, Utz (författare)
- Klinikum Leverkusen, Leverkusen, Germany,Hospital Leverkusen
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- Schliemann, Christoph (författare)
- Univ Hosp Munster, Munster, Germany,University Hospital Münster
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(creator_code:org_t)
- AMER SOC CLINICAL ONCOLOGY, 2019
- 2019
- Engelska.
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Ingår i: Journal of Clinical Oncology. - : AMER SOC CLINICAL ONCOLOGY. - 0732-183X .- 1527-7755. ; 37:29, s. 2632-2642
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- PURPOSE: Nucleophosmin 1 (NPM1) mutations are associated with a favorable prognosis in acute myeloid leukemia (AML) when an internal tandem duplication (ITD) in the fms-related tyrosine kinase 3 gene (FLT3) is absent (FLT3-ITDneg) or present with a low allelic ratio (FLT3-ITDlow). The 2017 European LeukemiaNet guidelines assume this is true regardless of accompanying cytogenetic abnormalities. We investigated the validity of this assumption.METHODS: We analyzed associations between karyotype and outcome in intensively treated patients with NPM1(mut)/FLT3-ITDneg/low AML who were prospectively enrolled in registry databases from nine international study groups or treatment centers.RESULTS: Among 2,426 patients with NPM1(mut)/FLT3-ITDneg/low AML, 2,000 (82.4%) had a normal and 426 (17.6%) had an abnormal karyotype, including 329 patients (13.6%) with intermediate and 83 patients (3.4%) with adverse-risk chromosomal abnormalities. In patients with NPM1(mut)/FLT3-ITDneg/low AML, adverse cytogenetics were associated with lower complete remission rates (87.7%, 86.0%, and 66.3% for normal, aberrant intermediate, and adverse karyotype, respectively; P < .001), inferior 5-year overall (52.4%, 44.8%, 19.5%, respectively; P < .001) and event-free survival (40.6%, 36.0%, 18.1%, respectively; P < .001), and a higher 5-year cumulative incidence of relapse (43.6%, 44.2%, 51.9%, respectively; P = .0012). These associations remained in multivariable mixed-effects regression analyses adjusted for known clinicopathologic risk factors (P < .001 for all end points). In patients with adverse-risk chromosomal aberrations, we found no significant influence of the NPM1 mutational status on outcome.CONCLUSION: Karyotype abnormalities are significantly associated with outcome in NPM1(mut)/FLT3-ITDneg/low AML. When adverse-risk cytogenetics are present, patients with NPM1(mut) share the same unfavorable prognosis as patients with NPM1 wild type and should be classified and treated accordingly. Thus, cytogenetic risk predominates over molecular risk in NPM1(mut)/FLT3-ITDneg/low AML.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
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Angenendt, Linus
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Röllig, Christop ...
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Montesinos, Pau
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Martinez-Cuadron ...
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Barragan, Eva
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Garcia, Raimundo
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visa fler...
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Botella, Carmen
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Martinez, Pilar
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Ravandi, Farhad
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Kadia, Tapan
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Kantarjian, Hago ...
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Cortes, Jorge
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Juliusson, Gunna ...
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Lazarevic, Vladi ...
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Höglund, Martin
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Lehmann, Sören
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Recher, Christia ...
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Pigneux, Arnaud
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Bertoli, Sarah
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Dumas, Pierre-Yv ...
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Dombret, Herve
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Preudhomme, Clau ...
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Micol, Jean-Bapt ...
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Terre, Christine
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Racil, Zdenek
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Novak, Jan
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Zak, Pavel
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Wei, Andrew H.
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Tiong, Ing S.
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Wall, Meaghan
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Estey, Elihu
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Shaw, Carole
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Exeler, Rita
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Wagenführ, Lisa
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Stölzel, Friedri ...
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Thiede, Christia ...
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Stelljes, Matthi ...
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Lenz, Georg
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Mikesch, Jan-Hen ...
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Serve, Hubert
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Ehninger, Gerhar ...
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Berdel, Wolfgang ...
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Kramer, Michael
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Krug, Utz
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Schliemann, Chri ...
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