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- Aad, G., et al.
(författare)
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- 2012
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Tidskriftsartikel (refereegranskat)
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- Aad, G., et al.
(författare)
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- 2012
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swepub:Mat__t (refereegranskat)
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- Ovadia, C., et al.
(författare)
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Ursodeoxycholic acid enriches intestinal bile salt hydrolase-expressing Bacteroidetes in cholestatic pregnancy
- 2020
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
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Tidskriftsartikel (refereegranskat)abstract
- Ursodeoxycholic acid (UDCA) treatment can reduce itch and lower endogenous serum bile acids in intrahepatic cholestasis of pregnancy (ICP). We sought to determine how it could influence the gut environment in ICP to alter enterohepatic signalling. The gut microbiota and bile acid content were determined in faeces from 35 pregnant women (14 with uncomplicated pregnancies and 21 with ICP, 17 receiving UDCA). Faecal bile salt hydrolase activity was measured using a precipitation assay. Serum fibroblast growth factor 19 (FGF19) and 7α-hydroxy-4-cholesten-3-one (C4) concentrations were measured following a standardised diet for 21 hours. Women with a high ratio of Bacteroidetes to Firmicutes were more likely to be treated with UDCA (Fisher’s exact test p = 0.0178) than those with a lower ratio. Bile salt hydrolase activity was reduced in women with low Bacteroidetes:Firmicutes. Women taking UDCA had higher faecal lithocholic acid (p < 0.0001), with more unconjugated bile acids than women with untreated ICP or uncomplicated pregnancy. UDCA-treatment increased serum FGF19, and reduced C4 (reflecting lower bile acid synthesis). During ICP, UDCA treatment can be associated with enrichment of the gut microbiota with Bacteroidetes. These demonstrate high bile salt hydrolase activity, which deconjugates bile acids enabling secondary modification to FXR agonists, enhancing enterohepatic feedback via FGF19. © 2020, The Author(s).
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7. |
- Piñero-García, Francisco, et al.
(författare)
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Radiological impact of naturally occurring radionuclides in bottled water
- 2021
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Ingår i: Food Control. - : Elsevier BV. - 0956-7135. ; 130
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Tidskriftsartikel (refereegranskat)abstract
- Consumption of bottled water is increasing year after year in Europe. Due to the local geology from where the water is extracted; bottled water could be enhanced with radionuclides. This study focuses on the activity concentrations of 210Po, 210Pb, 226Ra, 228Ra, 234U and 238U in bottled water available in the Swedish market, to assess the radiological impact to different age groups. The results showed that among the 26 brands studied, only three could exceed the threshold value for drinking water: 0.1 mSv/year. For two brands, the dose was mainly due to the activity concentrations of 238U and 234U being up to 714 and 1162 mBq/L, respectively. While for one brand, the dose was mainly due to the activity concentration of both 210Po and 210Pb being around 100 mBq/L. For the remainder brands, 228Ra was the main contributor to the committed effective dose.
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9. |
- Katselis, Dimitrios, et al.
(författare)
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Least Squares End Performance Experiment Design in Multicarrier Systems : The Sparse Preamble Case
- 2014
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Ingår i: 2014 European Control Conference (ECC). - : IEEE. - 9783952426913 ; , s. 13-18
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Konferensbidrag (refereegranskat)abstract
- In this paper, the problem of experiment design for the task of channel identification in cyclic prefixed orthogonal frequency division multiplexing (CP-OFDM) systems is revisited. So far, the optimal input sequences for least squares (LS) channel identification with respect to minimizing the channel mean square error (MSE) under an input energy constraint have been derived. Here, we investigate the same problem for the LS channel estimator, but when the design takes into account an end performance metric of interest, namely, the symbol estimate MSE. Based on some convex approximations, we verify that optimal sparse preambles, i.e, input vectors employing as many pilots as the channel length, for LS channel estimation in its classical context are near optimal in the aforementioned application-oriented context for the symbol estimate MSE.
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10. |
- Aad, G., et al.
(författare)
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- 2011
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Tidskriftsartikel (refereegranskat)
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