| 1. |
|
|
| 2. |
|
|
| 3. |
- Gaillard, Marie-Jose, et al.
(författare)
-
The use of modelling and simulation approach in reconstructing past landscapes from fossil pollen data: a review and results from the POLLANDCAL network
- 2008
-
Ingår i: Vegetation History and Archaeobotany. - : Springer Science and Business Media LLC. - 0939-6314 .- 1617-6278. ; 17:5, s. 419-443
-
Tidskriftsartikel (refereegranskat)abstract
- Information on past land cover in terms of absolute areas of different landscape units (forest, open land, pasture land, cultivated land, etc.) at local to regional scales is needed to test hypotheses and answer questions related to climate change (e.g. feedbacks effects of land-cover change), archaeological research, and nature conservancy (e.g. management strategy). The palaeoecological technique best suited to achieve quantitative reconstruction of past vegetation is pollen analysis. A simulation approach developed by Sugita (the computer model POLLSCAPE) which uses models based on the theory of pollen analysis is presented together with examples of application. POLLSCAPE has been adopted as the central tool for POLLANDCAL (POLlen/LANdscape CALibration), an international research network focusing on this topic. The theory behind models of the pollen-vegetation relationship and POLLSCAPE is reviewed. The two model outputs which receive greatest attention in this paper are the relevant source area of pollen (RSAP) and pollen loading in mires and lakes. Six examples of application of POLLSCAPE are presented, each of which explores a possible use of the POLLANDCAL tools and a means of validating or evaluating the models with empirical data. The landscape and vegetation factors influencing the size of the RSAP, the importance of pollen productivity estimates (PPEs) for the model outputs, the detection of small and rare patches of plant taxa in pollen records, and quantitative reconstructions of past vegetation and landscapes are discussed on the basis of these examples. The simulation approach is seen to be useful both for exploring different vegetation/landscape scenarios and for refuting hypotheses.
|
|
| 4. |
- Grape, Sophie, 1982-
(författare)
-
PWO Crystal Measurements and Simulation Studies of Anti-Hyperon Polarisation for PANDA
- 2008
-
Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The Gesellschaft für Schwerionenforschung (GSI) facility in Darmstadt, Germany, will be upgraded to accommodate a new generation of physics experiments. The future accelerator facility will be called FAIR and one of the experimentsat the site will be PANDA, which aims at performing hadron physics investigations by colliding anti-protons with protons. The licentiate thesis consistsof three sections related to PANDA. The first contains energy resolutionstudies of PbWO4 crystals, the second light yield uniformity studies of PbWO4 crystals and the third reconstruction of the lambda-bar-polarisation in the PANDA experiment. Two measurements of the energy resolution were performed at MAX-Lab in Lund, Sweden, with an array of 3x3 PbWO4 crystals using a tagged photon beam with energies between 19 and 56 MeV. For the April measurement, the crystals were cooled down to -15 degrees C and for the September measurement down to -25 degrees C. The measured relative energy resolution, /E, is decreasing from approximately 12% at 20 MeV to 7% at 55 MeV. In the standard energy resolution expression /E = a/ b/E c, the three parameters a, b and c seem to be strongly correlated and thus difficult to determine independently over this relative small energy range. The value of a was therefore fixed to that one would expect from Poisson statistics of the light collection yield (50 phe/MeV) and the results from fits were /E=0.45%/ 0.18%/EGeV 8.63% and /E = 0.45%/0.21%/EGeV 6.12% for the April and September measurements, respectively. The data from the September measurement was also combined with previous data from MAMI for higher energies, ranging from approximately 64 to 715 MeV. The global fit over the whole range of energies gave an energy resolution expression of /E = 1.6%/ 0.095%/EGeV 2.1%. Light yield uniformity studies of five PbWO4 crystals, three tapered and two non-tapered ones, have also been performed. The tapered crystals delivered a light output which increased with increasing distance from the Photo Multiplier Tube (PM tube). Black tape was put on different sides of one tapered crystals, far from the PM tube to try to get a more constant uniformity prole. It was seen that the light output profile depends on the position of the tape. Generally, the steep increase in light output at large distances from the PM tube could be damped. The third part of the thesis concerns the reconstruction of the lambdabar polarisation in the reaction . Events were generated using a modied generator from the PS185 experiment at LEAR. With a 100% polarisation perpendicular to the scattering plane, a polarisation of (99±1.8)% was reconstructed. Slight non-zero polarisations along the axis determined by the outgoing hyperon as well as the axis in the scattering plane, were also reconstructed. These were (4.1±2.1)% and (2.6±2.0)% respectively. From this investigation it was shown that the detector efficiency was not homogeneous and that slow pions are difficult to reconstruct.
|
|
| 5. |
- Grape, Sophie, 1982-
(författare)
-
Studies of PWO Crystals and Simulations of the p̅p →Λ̅Λ, Λ̅Σ0 Reactions for the PANDA Experiment
- 2009
-
Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The thesis comprises investigations of two topics related to the PANDA experiment. The first part is dedicated to energy resolution and light yield uniformity studies of PWO crystals for the electromagnetic calorimeter. The second part of the thesis is dedicated to simulation studies of the p̅p→Λ̅Λ and the p̅p→Λ̅Σ0 channels. Photon response measurements with one 3×3 crystals matrix of rectangular crystals and one 5×5 matrix with tapered crystals have been performed at the MAX-Lab synchrotron facility in Lund, Sweden. Photon energies in the range of 13-84 MeV were used. GEANT4 simulations were performed in order to find the most suitable method for adding the energy contributions and for calibration purposes. The widths, σ, of the resulting experimental summed energy peaks were fitted using the Novosibirsk distribution. The results show that the electromagnetic shower at 84 MeV is completely contained in the 5×5 matrix. The widths (σ) for the summed energy peaks were determined.Studies of the uniformity of the light yield were performed for crystals of three different shapes and different wrapping materials. The light yield as a function of distance between the point of energy depositions and the PM tube, was shown to be closely related to the crystal shape and the wrapping material. The p̅p→Λ̅Λ channel was studies at beam momenta of 1.64 GeV/c, 4 GeV/c and 15 GeV/c, while p̅p→Λ̅Σ0 was studied at 4 GeV/c. In the simulations, both phase space differential cross-sections and experimental differential cross-sections from PS185 were used as input. The purpose of the simulations was to show that the reaction channels can be reconstructed in the detector. Special interest was paid to the polarisation and spin correlations of the hyperons. The result is that there is acceptance of cosθ angular range over the full momentum range of the HESR for both channels. Using isotropic differential cross-sections, the polarisation for Λ̅ and Σ0 as well as spin correlations between Λ̅Λ and Λ̅Σ0 can be well reconstructed. Using the differential cross-sections from PS185, the particles are more likely to go forwards in their respective directions in the CM-system, thus making reconstruction over the full angular range more difficult at high beam momenta.
|
|
| 6. |
|
|
| 7. |
- Krege, Susanne, et al.
(författare)
-
European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part I
- 2008
-
Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 53:3, s. 478-496
-
Forskningsöversikt (refereegranskat)abstract
- Objectives: The first consensus report presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in the year 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, Amsterdam, The Netherlands. Methods: Medical oncologists, urological surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference, and incorporated the new data into updated and revised guidelines. As for the first meeting, the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The first part of the consensus paper describes the clinical presentation of the primary tumor, its treatment, the importance and treatment of testicular intraepithelial neoplasia (TIN), histological classification, staging and prognostic factors, and treatment of stage I seminoma and non-seminoma. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early- and advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. In addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
|
|
| 8. |
- Krege, Susanne, et al.
(författare)
-
European consensus conference on diagnosis and treatment of germ cell cancer: A report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): Part II
- 2008
-
Ingår i: European Urology. - : Elsevier BV. - 1873-7560 .- 0302-2838. ; 53:3, s. 497-513
-
Forskningsöversikt (refereegranskat)abstract
- Objectives: The first consensus report that had been presented by the European Germ Cell Cancer Consensus Group (EGCCCG) in 2004 has found widespread approval by many colleagues throughout the world. In November 2006, the group met a second time under the auspices of the Department of Urology of the Amsterdam Medical Center, The Netherlands. Methods: Medical oncologists, urologic surgeons, radiation oncologists as well as pathologists from several European countries reviewed and discussed the data that had emerged since the 2002 conference and incorporated the new data into updated and revised guidelines. As for the first meeting the methodology of evidence-based medicine (EBM) was applied. The results of the discussion were compiled by the writing committee. All participants have agreed to this final update. Results: The second part of the consensus paper includes the treatment of metastasised disease, residual tumour resection, salvage therapy, follow-up, and late toxicities. Conclusions: Whereas the vast majority of the recommendations made in 2004 remain valid 3 yr later, refinements in the treatment of early-stage as well as of advanced-stage testicular cancer have emerged from clinical trials. Despite technical improvements, expert clinical skills will continue to be one of the major determinants for the prognosis of patients with germ cell cancer. in addition, the particular needs of testicular cancer survivors have been acknowledged. (C) 2007 European Association of Urology. Published by Elsevier B.V. All rights reserved.
|
|
| 9. |
- Kühn, Ingolf, et al.
(författare)
-
MACIS: Minimisation of and Adaptation to Climate Change Impacts on BiodiverSity
- 2008
-
Ingår i: GAIA. - 0940-5550. ; 17:4, s. 393-395
-
Tidskriftsartikel (refereegranskat)abstract
- The recently finished EU funded project MACIS reviewed observed and projected climate change impacts on biodiversity. It assessed mitigation and adaptation options. It also reviewed and developed methods to assess future impacts of climate change on biodiversity including the identification of policy options to prevent and minimise these impacts.
|
|
| 10. |
- Maisnier-Patin, Sophie, et al.
(författare)
-
Genomic buffering mitigates the effects of deleterious mutations in bacteria
- 2005
-
Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 37:12, s. 1376-1379
-
Tidskriftsartikel (refereegranskat)abstract
- The relationship between the number of randomly accumulated mutations in a genome and fitness is a key parameter in evolutionary biology1, 2, 3, 4, 5. Mutations may interact such that their combined effect on fitness is additive (no epistasis), reinforced (synergistic epistasis) or mitigated (antagonistic epistasis). We measured the decrease in fitness caused by increasing mutation number in the bacterium Salmonella typhimurium using a regulated, error-prone DNA polymerase (polymerase IV, DinB). As mutations accumulated, fitness costs increased at a diminishing rate. This suggests that random mutations interact such that their combined effect on fitness is mitigated and that the genome is buffered against the fitness reduction caused by accumulated mutations. Levels of the heat shock chaperones DnaK and GroEL increased in lineages that had accumulated many mutations, and experimental overproduction of GroEL further increased the fitness of lineages containing deleterious mutations. These findings suggest that overexpression of chaperones contributes to antagonistic epistasis
|
|
