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Träfflista för sökning "WFRF:(Tichy Boris) srt2:(2012-2014)"

Sökning: WFRF:(Tichy Boris) > (2012-2014)

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1.
  • Agathangelidis, Andreas, et al. (författare)
  • Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia : a molecular classification with implications for targeted therapies
  • 2012
  • Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 119:19, s. 4467-4475
  • Tidskriftsartikel (refereegranskat)abstract
    • Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However, several issues need revisiting, including the criteria for identification of BCR stereotypy and its actual frequency as well as the identification of "CLL-biased" features in BCR Ig stereotypes. To this end, we examined 7596 Ig VH (IGHV-IGHD-IGHJ) sequences from 7424 CLL patients, 3 times the size of the largest published series, with an updated version of our purpose-built clustering algorithm. We document that CLL may be subdivided into 2 distinct categories: one with stereotyped and the other with nonstereotyped BCRs, at an approximate ratio of 1: 2, and provide evidence suggesting a different ontogeny for these 2 categories. We also show that subset-defining sequence patterns in CLL differ from those underlying BCR stereotypy in other B-cell malignancies. Notably, 19 major subsets contained from 20 to 213 sequences each, collectively accounting for 943 sequences or one-eighth of the cohort. Hence, this compartmentalized examination of VH sequences may pave the way toward a molecular classification of CLL with implications for targeted therapeutic interventions, applicable to a significant number of patients assigned to the same subset.
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2.
  • Pohlmann, Uwe, et al. (författare)
  • A Modelica library for real-time coordination modeling
  • 2012
  • Ingår i: Proc. of the 9th International Modelica Conference, Munich, Germany, Munich, September 3 - 5, 2012.
  • Konferensbidrag (refereegranskat)abstract
    • Increasingly, innovative functionality in embedded systems is realized by connecting previously autonomous embedded systems. This requires real-time communication and coordination between these connected systems. Modelica and the StateGraph2 library provide a good environment for modeling embedded systems including controllers and physics. However, it lacks appropriate support for modeling the communication and coordination part. In this paper, we present an extension to the State-Graph2 library that enables modeling asynchronous and synchronous communication and rich real-time constraints. We illustrate our extension of the State- Graph2 library by modeling and simulating two miniature robots driving in a platoon.
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