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- Tillmar, Andreas, et al.
(författare)
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Analysis of linkage and linkage disequilibrium for eight X-STR markers.
- 2008
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Ingår i: Forensic science international. Genetics. - : Elsevier. - 1878-0326 .- 1872-4973. ; 3:1, s. 37-41
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Tidskriftsartikel (refereegranskat)abstract
- X-chromosomal short tandem repeats (X-STR) have proven to be informative and useful in complex relationship testing. The main feature of X-STR markers, compared to autosomal forensic markers, is that all loci are located on the same chromosome. Thus, linkage and linkage disequilibrium may occur. The aim of this work was to study population genetic parameters of eight X-STR markers, located in four linkage groups. We present haplotype frequencies, based on 718 Swedish males, for the four linkage groups included in the Argus X-8 kit. Forensic efficiency parameters have been calculated as well as the allelic association between the tested markers for detection of linkage disequilibrium. To study the occurrences of recombination between the loci, both Swedish and Somali families were typed. A mathematical model for the estimation of recombination frequencies is presented and applied on the family samples. Our study showed that the tested markers all have highly informative forensic values and that there is a significant degree of linkage disequilibrium between the STR markers within the four linkage groups. Furthermore, based on the tested families, we also demonstrated that two of the linkage groups are partially linked. A consequence of these findings is that both linkage and linkage disequilibrium should be accounted for when producing likelihood ratios in relationship testing with X-STR markers.
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| 2. |
- Tillmar, Andreas O, et al.
(författare)
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Genetic variation of 15 autosomal STR loci in a Somali population
- 2009
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Ingår i: Forensic Science International. - : Elsevier. - 1872-4973 .- 1878-0326. ; 4:1, s. E17-E18
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Tidskriftsartikel (refereegranskat)abstract
- Allele frequencies for 15 autosomal STR loci included in the AmpFlSTR Identifiler kit (CSF1PO, D13S317, D16S539, D18S51, D19S433, D21S11, D2S1338, D3S1358, D5S818, D7S820, D8S1179, FGA, TH01, TPOX, VWA) were obtained from the analysis of 404 individuals with Somali origin. The overall match probability for the 15 studied loci was 1 in 1.18 X 10(17) and the combined power of exclusion was 0.999997676. Deviation from Hardy-Weinberg equilibrium was observed for locus D2S1338 after correction for multiple testing. When comparing allele frequencies with five other African populations (Karamoja (Uganda), Mozambique, Tanzania and two other Somali population sample sets), only the Somali populations did not show significant differences for any of the tested loci.
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