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Sökning: WFRF:(Tim R) > (2000-2004)

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1.
  • Kalscheuer, Vera M, et al. (författare)
  • Mutations in the polyglutamine binding protein 1 gene cause X-linked mental retardation
  • 2003
  • Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 35:4, s. 313-315
  • Tidskriftsartikel (refereegranskat)abstract
    • We found mutations in the gene PQBP1 in 5 of 29 families with nonsyndromic (MRX) and syndromic (MRXS) forms of X-linked mental retardation (XLMR). Clinical features in affected males include mental retardation, microcephaly, short stature, spastic paraplegia and midline defects. PQBP1 has previously been implicated in the pathogenesis of polyglutamine expansion diseases. Our findings link this gene to XLMR and shed more light on the pathogenesis of this common disorder.
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4.
  • Pizzari, Tommaso, et al. (författare)
  • Sophisticated sperm allocation in male fowl
  • 2003
  • Ingår i: Nature. - : Nature Publishing Group. - 0028-0836 .- 1476-4687. ; 426:6962, s. 70-74
  • Tidskriftsartikel (refereegranskat)abstract
    • When a female is sexually promiscuous, the ejaculates of different males compete for the fertilization of her eggs; the more sperm a male inseminates into a female, the more likely he is to fertilize her eggs. Because sperm production is limited and costly, theory predicts that males will strategically allocate sperm (1) according to female promiscuity, (2) saving some for copulations with new females, and (3) to females producing more and/or better offspring. Whether males allocate sperm in all of these ways is not known, particularly in birds where the collection of natural ejaculates only recently became possible. Here we demonstrate male sperm allocation of unprecedented sophistication in the fowl Gallus gallus. Males show status-dependent sperm investment in females according to the level of female promiscuity; they progressively reduce sperm investment in a particular female but, on encountering a new female, instantaneously increase their sperm investment; and they preferentially allocate sperm to females with large sexual ornaments signalling superior maternal investment. Our results indicate that female promiscuity leads to the evolution of sophisticated male sexual behaviour.
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5.
  • Wessling, C., et al. (författare)
  • Antioxidant ability of bht- and ?-tocopherolimpregnated ldpe film in packaging of oatmeal
  • 2001
  • Ingår i: Journal of the Science of Food and Agriculture. - 0022-5142 .- 1097-0010. ; 81:2, s. 194-201
  • Tidskriftsartikel (refereegranskat)abstract
    • Cereals in general, and particularly oatmeals, are considered rather sensitive to oxidation owing to their relatively high fat content. The addition of antioxidants can sometimes prolong the shelf-life of products. The aim of the present study was to investigate how the rate of lipid oxidation ora packaged oatmeal product was affected by the nature and level of antioxidants incorporated in an LDPE film structure. The stability of the product, which was determined by hexanal analysis using GC-MS and by electronic nose analysis, showed very small variations over the chosen storage period. No oxidation, as determined by hexanal levels in the oatmeal, was initiated during storage, but small variations in volatile profile were seen among the samples analysed by the electronic nose. The product stored in the BHT-impregnated LDPE film had undergone the least change during 10 weeks of storage at 20°C. ?-Tocopherol-impregnated LDPE film did not appear to prolong the shelf-life of the oatmeal at all. © 2000 Society of Chemical Industry.
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