Sökning: WFRF:(Tipper Sarah J.)
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Pre-diagnostic circ...
Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition
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- Lin, Crystal (författare)
- University of Oxford
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- Travis, Ruth C. (författare)
- University of Oxford
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- Appleby, Paul N. (författare)
- University of Oxford
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- Tipper, Sarah (författare)
- University of Oxford
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- Weiderpass, Elisabete (författare)
- Karolinska Institute,Karolinska Institutet,University of Helsinki,Cancer Registry of Norway, Institute of Population-Based Cancer Research,UiT The Arctic University of Norway, Tromsø
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- Chang-Claude, Jenny (författare)
- German Cancer Research Centre
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- Gram, Inger T. (författare)
- UiT The Arctic University of Norway, Tromsø
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Kiemeney, Lambertus A. (författare)
- Radboud University Nijmegen
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- Ljungberg, Börje, 1949- (författare)
- Umeå University,Umeå universitet,Urologi och andrologi
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- Tumino, Rosario (författare)
- Civic and M.P Arezzo Hospital
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- Tjonneland, Anne (författare)
- Danish Cancer Society
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- Roswall, Nina (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Boutron-Ruault, Marie-Christine (författare)
- Stabilite genetique et oncogenese,Versailles Saint-Quentin-en-Yvelines University
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- Manciniveri, Francesca Romana (författare)
- Versailles Saint-Quentin-en-Yvelines University,Stabilite genetique et oncogenese
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- Severi, Gianluca (författare)
- Versailles Saint-Quentin-en-Yvelines University,Stabilite genetique et oncogenese
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- Trichopoulou, Antonia (författare)
- Hellenic Health Foundation, Athens
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- Masala, Giovanna (författare)
- Cancer Research and Prevention Institute (ISPO)
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- Sacerdote, Carlotta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Agnoli, Claudia (författare)
- Istituto Nazionale dei Tumori
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- Panico, Salvatore (författare)
- University of Naples Federico II
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- Bueno-de-Mesquita, Bas (författare)
- Imperial College London,National Institute for Public Health and the Environment (RIVM),University of Malaya,University Medical Center Utrecht
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- Peeters, Petra H. (författare)
- University Medical Center Utrecht
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- Salamanca-Fernandez, Elena (författare)
- University of Granada,CIBER Epidemiology and Public Health (CIBERESP)
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- Chirlaque, Maria-Dolores (författare)
- CIBER Epidemiology and Public Health (CIBERESP),Murcia Regional Health Council,University of Murcia
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- Ardanaz, Eva (författare)
- Health Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)
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- Dorronsoro, Miren (författare)
- Basque Regional Health Department
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- Menendez, Virginia (författare)
- Public Health Directorate
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- Lujan-Barroso, Leila (författare)
- University of Barcelona,Bellvitge University Hospital-IDIBELL
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- Liedberg, Fredrik (författare)
- Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Skåne University Hospital
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- Freisling, Heinz (författare)
- International Agency for Research on Cancer, World Health Organization
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- Gunter, Marc (författare)
- International Agency for Research on Cancer, World Health Organization
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- Aune, Dagfinn (författare)
- Bjørknes University College,Imperial College London
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- Cross, Amanda J. (författare)
- Imperial College London
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- Riboli, Elio (författare)
- Imperial College London
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- Key, Timothy J. (författare)
- University of Oxford
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- Perez-Cornago, Aurora (författare)
- University of Oxford
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(creator_code:org_t)
- 2018-09-11
- 2018
- Engelska.
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Ingår i: International Journal of Cancer. - : WILEY. - 0020-7136 .- 1097-0215. ; 143:10, s. 2351-2358
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https://onlinelibrar...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Previous in vitro and case–control studies have found an association between the insulin‐like growth factor (IGF)‐axis and bladder cancer risk. Circulating concentrations of IGF‐I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre‐diagnostic circulating IGF‐I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre‐diagnostic plasma concentrations of IGF‐I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case–control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow‐up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre‐diagnostic circulating IGF‐I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66–1.24, ptrend = 0.40) or UCC (n of cases = 776; 0.91, 0.65–1.26, ptrend = 0.40). There was no significant evidence of heterogeneity in the association of IGF‐I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (pheterogeneity > 0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF‐I concentrations and bladder cancer risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- bladder cancer
- urothelial cell carcinoma
- IGF-I
- EPIC cohort
- prospective
- bladder cancer
- EPIC cohort
- IGF-I
- prospective
- urothelial cell carcinoma
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Lin, Crystal
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Travis, Ruth C.
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Appleby, Paul N.
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Tipper, Sarah
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Weiderpass, Elis ...
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Chang-Claude, Je ...
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visa fler...
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Gram, Inger T.
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Kaaks, Rudolf
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Kiemeney, Lamber ...
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Ljungberg, Börje ...
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Tumino, Rosario
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Tjonneland, Anne
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Roswall, Nina
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Overvad, Kim
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Boutron-Ruault, ...
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Manciniveri, Fra ...
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Severi, Gianluca
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Trichopoulou, An ...
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Masala, Giovanna
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Sacerdote, Carlo ...
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Agnoli, Claudia
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Panico, Salvator ...
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Bueno-de-Mesquit ...
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Peeters, Petra H ...
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Salamanca-Fernan ...
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Chirlaque, Maria ...
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Ardanaz, Eva
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Dorronsoro, Mire ...
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Menendez, Virgin ...
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Lujan-Barroso, L ...
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Liedberg, Fredri ...
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Freisling, Heinz
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Gunter, Marc
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Aune, Dagfinn
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Cross, Amanda J.
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Riboli, Elio
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Key, Timothy J.
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Perez-Cornago, A ...
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