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Investigation of mu...
Investigation of multiple populations highlight VEGFA polymorphisms to modulate anterior cruciate ligament injury
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- Feldmann, Daneil C. (författare)
- Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa
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- Rahim, Masouda (författare)
- Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa
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- Suijkerbuijk, Mathijs A. M. (författare)
- Department of Orthopaedic Surgery, Erasmus MC, University Medical Center, Rotterdam, Netherlands,Univ Med Ctr, Dept Orthopaed Surg, Erasmus MC, Rotterdam, Netherlands
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- Laguette, Mary-Jessica N. (författare)
- Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;UCT Res Ctr Hlth Phys Act Lifestyle & Sport, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
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- Cieszczyk, Paweł (författare)
- Faculty of Physical Education, Gdańsk University of Physical Education and Sport, Gdańsk, Poland,Gdansk Univ Phys Educ & Sport, Fac Phys Educ, Gdansk, Poland
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- Ficek, Krzysztof (författare)
- Faculty of Physiotherapy, Jerzy Kukuczka Academy of Physical Education in Katowice, Katowice, Poland,Jerzy Kukuczka Acad Phys Educ Katowice, Fac Physiotherapy, Katowice, Poland
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- Huminska-Lisowska, Kinga (författare)
- Faculty of Physical Education, Gdańsk University of Physical Education and Sport, Gdańsk, Poland,Gdansk Univ Phys Educ & Sport, Fac Phys Educ, Gdansk, Poland
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- Häger, Charlotte K., Professor, 1962- (författare)
- Umeå universitet,Institutionen för samhällsmedicin och rehabilitering,Umeå Univ, Dept Community Med & Rehabil, Umeå, Sweden
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- Stattin, Evalena (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi
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- Nilsson, Kjell G. (författare)
- Umeå universitet,Ortopedi,Umeå Univ, Dept Surg & Perioperat Sci, Umeå, Sweden
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- Alvarez-Rumero, Javier (författare)
- Institute for Health and Sport (iHeS), Victoria University, VIC, Melbourne, Australia,Victoria Univ, Inst Hlth & Sport iHeS, Melbourne, Vic, Australia
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- Eynon, Nir (författare)
- Institute for Health and Sport (iHeS), Victoria University, VIC, Melbourne, Australia,Victoria Univ, Inst Hlth & Sport iHeS, Melbourne, Vic, Australia
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- Feller, Julian (författare)
- OrthoSport Victoria, Epworth Healthcare, VIC, Melbourne, Australia
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- Tirosh, Oren (författare)
- School of Health Sciences, Swinburne University of Technology, VIC, Melbourne, Australia,Swinburne Univ Technol, Sch Hlth Sci, Melbourne, Vic, Australia
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- Posthumus, Michael (författare)
- Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
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- Chimusa, Emile R. (författare)
- Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Department of Pathology, Division of Human Genetics, University of Cape Town, Cape Town, South Africa,Univ Cape Town, Fac Hlth Sci, Inst Infect Dis & Mol Med, Cape Town, South Africa.;Univ Cape Town, Dept Pathol, Div Human Genet, Cape Town, South Africa
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- Collins, Malcolm (författare)
- Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;UCT Res Ctr Hlth Phys Act Lifestyle & Sport, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
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- September, Alison V. (författare)
- Division of Exercise Science and Sports Medicine, Department of Human Biology, University of Cape Town, Cape Town, South Africa; UCT Research Centre for Health through Physical Activity, Lifestyle and Sport, Cape Town, South Africa; International Federation of Sports Medicine (FIMS) Collaborative Centre of Sports Medicine, Cape Town, South Africa,Univ Cape Town, Dept Human Biol, Div Exercise Sci & Sports Med, Cape Town, South Africa.;UCT Res Ctr Hlth Phys Act Lifestyle & Sport, Cape Town, South Africa.;Int Federat Sports Med FIMS Collaborat Ctr Sports, Cape Town, South Africa
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(creator_code:org_t)
- 2021-10-18
- 2022
- Engelska.
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Ingår i: Journal of Orthopaedic Research. - : John Wiley & Sons. - 0736-0266 .- 1554-527X. ; 40:7, s. 1604-1612
- Relaterad länk:
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https://onlinelibrar...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Polymorphisms in VEGFA and KDR encoding proteins have been associated with anterior cruciate ligament (ACL) injury risk. We leveraged a collective sample from Sweden, Poland, and Australia to investigate the association of functional polymorphisms in VEGFA and KDR with susceptibility to ACL injury risk. Using a case–control genetic association approach, polymorphisms in VEGFA and KDR were genotyped and haplotypes inferred from 765 controls, and 912 cases clinically diagnosed with ACL rupture. For VEGFA, there was a significant overrepresentation of the rs2010963 CC genotype (p = 0.0001, false discovery rate [FDR]: p = 0.001, odds ratio [OR]: 2.16, 95% confidence interval [CI]: 1.47–3.19) in the combined ACL group (18%) compared to the combined control group (11%). The VEGFA (rs699947 C/A, rs1570360 G/A, rs2010963 G/C) A-A-G haplotype was significantly (p = 0.010, OR: 0.85, 95% CI: 0.69–1.05) underrepresented in the combined ACL group (23%) compared to the combined control group (28%). In addition, the A-G-G construct was significantly (p = 0.036, OR: 0.81, 95% CI: 0.64–1.02) underrepresented in the combined ACL group (12%) compared to the combined CON group (16%). Our findings support the association of the VEGFA rs2010963 CC genotype with increased risk and (ii) the VEGFA A-A-G haplotype with a reduced risk, and are in alignment with the a priori hypothesis. Collectively identifying a genetic interval within VEGFA to be implicated in ACL risk modulation and highlight further the importance of vascular regulation in ligament biology.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Sjukgymnastik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Physiotherapy (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Ortopedi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Orthopaedics (hsv//eng)
Nyckelord
- ACL
- angiogenesis
- genetic association studies
- ligament healing
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Feldmann, Daneil ...
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Rahim, Masouda
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Suijkerbuijk, Ma ...
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Laguette, Mary-J ...
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Cieszczyk, Paweł
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Ficek, Krzysztof
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Huminska-Lisowsk ...
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Häger, Charlotte ...
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Stattin, Evalena
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Nilsson, Kjell G ...
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Alvarez-Rumero, ...
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Eynon, Nir
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Feller, Julian
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Tirosh, Oren
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Posthumus, Micha ...
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Chimusa, Emile R ...
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Collins, Malcolm
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September, Aliso ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Sjukgymnastik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Ortopedi
- Artiklar i publikationen
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Journal of Ortho ...
- Av lärosätet
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Umeå universitet
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Uppsala universitet