| 1. |
- Ekström, J., et al.
(författare)
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Increased polyamine formation in rat salivary glands by stimulation of their autonomic nerve supply
- 1985
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Ingår i: Archives of Oral Biology. - 0003-9969. ; 30:11-12, s. 773-775
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Tidskriftsartikel (refereegranskat)abstract
- Ornithine decarboxylase (ODC), a key enzyme in polyamine biosynthesis, was measured in the three major salivary glands of rats and mice. Enzyme activity and glandular putrescine content increased after continuous stimulation of the parasympathetic or sympathetic salivary nerves for 3 h. The activity was markedly reduced in animals fasted for 24 h to decrease nervous-reflex activation of the glands. Thus ODC activity may be linked with synthesis of secretory macromolecules.
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| 2. |
- Ekström, J., et al.
(författare)
-
Receptors involved in the nervous system regulation of polyamine metabolism in rat salivary glands
- 1989
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Ingår i: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 135:3, s. 61-255
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Tidskriftsartikel (refereegranskat)abstract
- Polyamines are important for protein synthesis and tissue growth. In rat salivary glands, the activity of ornithine decarboxylase (ODC), the enzyme catalysing the formation of putrescine, and the content of putrescine, spermidine, spermine and N1-acetylspermidine were assayed after parasympathetic or sympathetic nerve stimulation in the presence of various autonomic receptor blockers. Increases in ODC activity occurred on activation of non-adrenergic and non-cholinergic receptors in response to parasympathetic nerve stimulation and on activation of alpha(alpha 1)- as well as of beta(beta 1)-adrenoceptors in response to sympathetic nerve stimulation. Moreover, in parotid glands, a beta(beta 1)-adrenoceptor-mediated inverse pathway for putrescine formation seemed to exist: from spermidine via N1-acetylspermidine.
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| 3. |
- Ekström, J., et al.
(författare)
-
Spermidine/spermine-N1-acetyltransferase activity in isoprenaline-stimulated rat salivary glands
- 1989
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Ingår i: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 135:3, s. 54-249
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Tidskriftsartikel (refereegranskat)abstract
- In parotid, sublingual and submaxillary glands stimulated by continuous intravenous infusion of isoprenaline at various doses for 3 h, the concentrations of the polyamines putrescine, spermidine, spermine and N1-acetylspermidine as well as the activities of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase were determined. Ornithine decarboxylase is the enzyme that catalyses the formation of putrescine from ornithine. The most striking effect was observed in parotid glands. Here, the beta-adrenergic agonist increased the activity of spermidine/spermine-N1-acetyltransferase markedly, but only slightly (if at all) that of ornithine decarboxylase. It also increased the concentrations of N1-acetylspermidine and putrescine markedly. The result obtained in this gland indicates interconversion of higher polyamines to putrescine.
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