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Specific changes in...
Specific changes in conduction velocity recovery cycles of single nociceptors in a patient with erythromelalgia with the I848T gain-of-function mutation of Na(v)1.7
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- Namer, Barbara (författare)
- Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, D-91054 Erlangen, Germany.
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- Orstavik, Kristin (författare)
- Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Neurol, N-0027 Oslo, Norway.
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- Schmidt, Roland (författare)
- Uppsala universitet,Klinisk neurofysiologi
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- Kleggetveit, Inge-Petter (författare)
- Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Neurol, N-0027 Oslo, Norway.
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- Weidner, Christian (författare)
- Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, D-91054 Erlangen, Germany.
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- Mork, Cato (författare)
- Norwegian Univ Sci & Technol, Inst Canc Res & Mol Med, N-7034 Trondheim, Norway.
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- Kvernebo, Mari Skylstad (författare)
- Oslo Univ Hosp, Dept Rheumatol Skin & Infect Dis, Oslo, Norway.
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- Kvernebo, Knut (författare)
- Oslo Univ Hosp, Dept Vasc Surg, Oslo, Norway.
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- Salter, Hugh (författare)
- Karolinska Institutet
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- Carr, Thomas Hedley (författare)
- AstraZeneca R&D, Macclesfield, Cheshire, England.
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- Segerdahl, Marta (författare)
- Karolinska Inst, AstraZeneca Translat Sci Ctr, Dept Clin Neurosci, S-10401 Stockholm, Sweden.
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- Quiding, Hans (författare)
- Karolinska Inst, AstraZeneca Translat Sci Ctr, Dept Clin Neurosci, S-10401 Stockholm, Sweden.
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- Waxman, Stephen George (författare)
- Yale Univ, Sch Med, Ctr Neurosci & Regenerat Res, New Haven, CT USA.
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- Handwerker, Hermann Otto (författare)
- Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, D-91054 Erlangen, Germany.
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- Torebjörk, Hans Erik (författare)
- Uppsala universitet,Klinisk neurofysiologi
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- Jorum, Ellen (författare)
- Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Neurol, N-0027 Oslo, Norway.
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- Schmelz, Martin (författare)
- Heidelberg Univ, Dept Anesthesiol Mannheim, D-68167 Mannheim, Germany.
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Univ Erlangen Nurnberg, Dept Physiol & Pathophysiol, D-91054 Erlangen, Germany Univ Oslo, Rikshosp, Oslo Univ Hosp, Dept Neurol, N-0027 Oslo, Norway. (creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2015
- 2015
- Engelska.
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Ingår i: Pain. - : Ovid Technologies (Wolters Kluwer Health). - 0304-3959 .- 1872-6623. ; 156:9, s. 1637-1646
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Seven patients diagnosed with erythromelalgia (EM) were investigated by microneurography to record from unmyelinated nerve fibers in the peroneal nerve. Two patients had characterized variants of sodium channel Na(v)1.7 (I848T, I228M), whereas no mutations of coding regions of Na(v)s were found in 5 patients with EM. Irrespective of Na(v)1.7 mutations, more than 50% of the silent nociceptors in the patients with EM showed spontaneous activity. In the patient with mutation I848T, all nociceptors, but not sympathetic efferents, displayed enhanced early subnormal conduction in the velocity recovery cycles and the expected late subnormality was reversed to supranormal conduction. The larger hyperpolarizing shift of activation might explain the difference to the I228M mutation. Sympathetic fibers that lack Na(v)1.8 did not show supranormal conduction in the patient carrying the I848T mutation, confirming in human subjects that the presence of Na(v)1.8 crucially modulates conduction in cells expressing EM mutant channels. The characteristic pattern of changes in conduction velocity observed in the patient with the I848T gain-of function mutation in Na(v)1.7 could be explained by axonal depolarization and concomitant inactivation of Na(v)1.7. If this were true, activity-dependent hyperpolarization would reverse inactivation of Na(v)1.7 and account for the supranormal CV. This mechanism might explain normal pain thresholds under resting conditions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Nyckelord
- Microneurography
- Peripheral nerve
- Sodium channel
- Electrophysiology
- Nociceptor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Namer, Barbara
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Orstavik, Kristi ...
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Schmidt, Roland
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Kleggetveit, Ing ...
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Weidner, Christi ...
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Mork, Cato
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Kvernebo, Mari S ...
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Kvernebo, Knut
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Salter, Hugh
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Carr, Thomas Hed ...
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Segerdahl, Marta
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Quiding, Hans
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Waxman, Stephen ...
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Handwerker, Herm ...
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Torebjörk, Hans ...
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Jorum, Ellen
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Schmelz, Martin
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