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- Bergquist, J, et al.
(författare)
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Suicide-attempters having immunoglobulin G with affinity for doparnine in cerebrospinal fluid
- 2002
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Ingår i: European Neuropsychopharmacology. - 1873-7862. ; 12:2, s. 153-158
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Forskningsöversikt (refereegranskat)abstract
- Altered immunological functions and changes in the monoaminergic neurotransmitter systems are two important observations made previously in the study of possible etiological and pathophysiological factors for psychiatric disorders. In search of tentative autoimmune mechanisms involved in these disorders we studied the presence of immunoglobulin G (DA-IgG) with affinity for the monoamine dopamine (DA) in cerebrospinal fluid (CSF) using ELISA. In CSF from 49 suicide attempters the titer of DA-IgG was significantly higher (P<0.001) than in CSF obtained from control subjects undergoing neurological investigation, The results in the present study indicate that an autoimmune mechanism may be involved in the dopaminergic neurotransmitter system and may be of pathophysiological importance in psychiatric disorders connected to an attempt of suicide, (C) 2002 Published by Elsevier Science BV/ECNP.
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| 2. |
- Borna, Petter, et al.
(författare)
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Self-poisonings with drugs by adolescents in the Lund catchment area
- 2001
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Ingår i: Nordic Journal of Psychiatry. - : Informa UK Limited. - 1502-4725 .- 0803-9488. ; 55:5, s. 325-328
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Tidskriftsartikel (refereegranskat)abstract
- Our objective was to investigate which drugs young people who attempt suicide use in the Lund catchment area-eight municipalities in Skane, southern Sweden. All patients aged up to 18 years admitted to Lund University Hospital after deliberate or probably deliberate self-poisoning from 1 January 1991 until 31 December 1995 were included. Forty-nine (58%) had used a single drug; 20 (24%) had used 3 or more drugs. Fifty-two (61%) used analgesics-paracetamol was used by 38 (45%) and propoxyphene by 17 (20%). Thirty-one (36%) had ingested psychotropics-13 used benzodiazepines, 10 antidepressants, and 8 antipsychotics. Eleven (15%) had used drugs in combination with alcohol. We conclude that it is important to follow changes in self-poisoning patterns, to monitor the effects of preventive work and discover new trends in drug use.
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| 6. |
- Niméus, Anders, et al.
(författare)
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High Suicidal Intent Scores Indicate Future Suicide
- 2002
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Ingår i: Archives of Suicide Research. - : Informa UK Limited. - 1543-6136 .- 1381-1118. ; 6:3, s. 211-219
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Tidskriftsartikel (refereegranskat)abstract
- he aim of this study was to scrutinize individual items as well as total scores of the Suicidal Intent Scale (SIS) in order to find out its usefulness for predicting suicide. Consecutive patients (N=555) were evaluated and rated with SIS shortly after a suicide attempt. When followed up at a mean time of 4.5 years, 22 (4%) had committed suicide. Those who later committed suicide had been scored significantly higher than those who did not commit suicide. In an effort to find a score-limit of the SIS which could be associated with future suicide, we formulated a receiver operating characteristic curve. From this we were able to detect a sensitivity of 90% and a specificity of 60.3% of scores of 19 and above in people aged 55 years and older. In a logistic regression analysis we also found that age above 55 years, mood disorder diagnoses and SIS scores of 19 or above significantly predicted suicide. Our conclusion is that the SIS could be a valuable tool in predicting suicide, especially in elderly suicide attempters.
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