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Long-term follow-up...
Long-term follow-up of the hepatitis CHENCORE cohort: response to therapy and occurrence of liver-related complications
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Pradat, P. (författare)
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Tillmann, H. L. (författare)
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Sauleda, S. (författare)
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- Braconier, Jean Henrik (författare)
- Lund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine
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Saracco, G. (författare)
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Thursz, M. (författare)
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Goldin, R. (författare)
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Winkler, R. (författare)
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Alberti, A. (författare)
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Esteban, J.-I. (författare)
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Hadziyannis, S. (författare)
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Rizzetto, M. (författare)
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Thomas, H. (författare)
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Manns, M. P. (författare)
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Trepo, C. (författare)
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(creator_code:org_t)
- Wiley, 2007
- 2007
- Engelska.
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Ingår i: Journal of Viral Hepatitis. - : Wiley. - 1365-2893 .- 1352-0504. ; 14:8, s. 556-563
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The aims of the study were to verify the longterm effect of time on viral clearance in hepatitis C virus (HCV) patients and to find out factors possibly associated with disease progression. A total of 1641 patients recruited from eight European centres in 1996-1.997 were re-analysed 5-7 years after inclusion. The occurrence of decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation was analysed in relation to different host and viral factors. Ninety-three per cent of the HCV patients who had cleared the virus (spontaneously or after antiviral therapy) remained HCV-RNA-negative during follow up and may be considered as 'cured'. Among patients who were sustained responders at inclusion, 2.3% developed liver complications during follow up, and 31% of non-responders did. Advanced age at infection and presence of the human leucocyte antigen (HLA) DRBI*1201-3 allele were possibly associated with a higher rate of progression to decompen- sated cirrhosis or HCC. Decompensated cirrhosis might be further associated with male gender, non-response to previous therapy, and lack of FILA DRBI*1301 allele, whereas HCC seems to be associated with the presence of the HLA DQ02 allele. Long-term follow up of HCV patients indicates that virological response persists over time and is associated with a very low incidence of liver complications. Advanced age at inclusion. advanced age at infection, viral genotype 1, non-response to previous therapy and possibly some specific HLA alleles are factors independently associated with a faster rate of progression towards liver complications. The large proportion of patients lost to follow up stresses the need for a strengthened and optimized management of HCV patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- human leucocyte antigen
- carcinoma
- hepatocellular
- hepatitis C
- follow up
- cirrhosis
- complications
- viral clearance
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Pradat, P.
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Tillmann, H. L.
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Sauleda, S.
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Braconier, Jean ...
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Saracco, G.
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Thursz, M.
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visa fler...
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Goldin, R.
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Winkler, R.
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Alberti, A.
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Esteban, J.-I.
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Hadziyannis, S.
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Rizzetto, M.
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Thomas, H.
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Manns, M. P.
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Trepo, C.
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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Lunds universitet