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- Martin, P., et al.
(författare)
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Overview of the RFX-mod fusion science programme
- 2013
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 53:10, s. 104018-
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Forskningsöversikt (refereegranskat)abstract
- This paper reports the highlights of the RFX-mod fusion science programme since the last 2010 IAEA Fusion Energy Conference. The RFX-mod fusion science programme focused on two main goals: exploring the fusion potential of the reversed field pinch (RFP) magnetic configuration and contributing to the solution of key science and technology problems in the roadmap to ITER. Active control of several plasma parameters has been a key tool in this endeavour. New upgrades on the system for active control of magnetohydrodynamic (MHD) stability are underway and will be presented in this paper. Unique among the existing fusion devices, RFX-mod has been operated both as an RFP and as a tokamak. The latter operation has allowed the exploration of edge safety factor q edge < 2 with active control of MHD stability and studies concerning basic energy and flow transport mechanisms. Strong interaction has continued with the stellarator community in particular on the physics of helical states and on three-dimensional codes.
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| 5. |
- Deo, R., et al.
(författare)
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Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: A genome-wide association study of 13,372 participants
- 2013
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Ingår i: Heart Rhythm. - : Elsevier BV. - 1547-5271. ; 10:3, s. 401-408
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND Genome-wide association studies have identified several genetic loci associated with variation in resting heart rate in European and Asian populations. No study has evaluated genetic variants associated with heart rate in African Americans. OBJECTIVE To identify novel genetic variants associated with resting heart rate in African Americans. METHODS Ten cohort studies participating in the Candidate-gene Association Resource and Continental Origins and Genetic Epidemiology Network consortia performed genome-wide genotyping of singe nucleotide polymorphisms (SNPs) and imputed 2,954,965 SNPs using HapMap YRI and CEU panels in 13,372 participants of African ancestry. Each study measured the RR interval (ms) from 10-second resting 12-lead electrocardiograms and estimated RR-SNP associations using covariate-adjusted linear regression. Random-effects meta-analysis was used to combine cohort-specific measures of association and identify genome-wide significant loci (P <= 2.5 x 10(-8)). RESULTS Fourteen SNPs on chromosome 6q22 exceeded the genome-wide significance threshold. The most significant association was for rs9320841 (+13 ms per minor allele; P = 4.98 x 10(-15)). This SNP was approximately 350 kb downstream of GJA1, a locus previously identified as harboring SNPs associated with heart rate in Europeans. Adjustment for rs9320841 also attenuated the association between the remaining 13 SNPs in this region and heart rate. In addition, SNPs in MYH6, which have been identified in European genome-wide association study, were associated with similar changes in the resting heart rate as this population of African Americans. CONCLUSIONS An intergenic region downstream of GJA1 (the gene encoding connexin 43, the major protein of the human myocardial gap junction) and an intragenic region within MYH6 are associated with variation in resting heart rate in African Americans as well as in populations of European and Asian origin.
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- Wormser, David, et al.
(författare)
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Adult height and the risk of cause-specific death and vascular morbidity in 1 million people : individual participant meta-analysis
- 2012
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Ingår i: International Journal of Epidemiology. - : Oxford University Press (OUP). - 0300-5771 .- 1464-3685. ; 41:5, s. 1419-1433
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundThe extent to which adult height, a biomarker of the interplay of genetic endowment and early-life experiences, is related to risk of chronic diseases in adulthood is uncertain.MethodsWe calculated hazard ratios (HRs) for height, assessed in increments of 6.5 cm, using individual-participant data on 174 374 deaths or major non-fatal vascular outcomes recorded among 1 085 949 people in 121 prospective studies.ResultsFor people born between 1900 and 1960, mean adult height increased 0.5-1 cm with each successive decade of birth. After adjustment for age, sex, smoking and year of birth, HRs per 6.5 cm greater height were 0.97 (95% confidence interval: 0.96-0.99) for death from any cause, 0.94 (0.93-0.96) for death from vascular causes, 1.04 (1.03-1.06) for death from cancer and 0.92 (0.90-0.94) for death from other causes. Height was negatively associated with death from coronary disease, stroke subtypes, heart failure, stomach and oral cancers, chronic obstructive pulmonary disease, mental disorders, liver disease and external causes. In contrast, height was positively associated with death from ruptured aortic aneurysm, pulmonary embolism, melanoma and cancers of the pancreas, endocrine and nervous systems, ovary, breast, prostate, colorectum, blood and lung. HRs per 6.5 cm greater height ranged from 1.26 (1.12-1.42) for risk of melanoma death to 0.84 (0.80-0.89) for risk of death from chronic obstructive pulmonary disease. HRs were not appreciably altered after further adjustment for adiposity, blood pressure, lipids, inflammation biomarkers, diabetes mellitus, alcohol consumption or socio-economic indicators.ConclusionAdult height has directionally opposing relationships with risk of death from several different major causes of chronic diseases.
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- Trevisan, M., et al.
(författare)
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Analysis of old very metal rich stars in the solar neighbourhood
- 2011
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 535, s. A42-
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Tidskriftsartikel (refereegranskat)abstract
- Context. A sample of mostly old metal-rich dwarf and turn-off stars with high eccentricity and low maximum height above the Galactic plane has been identified. From their kinematics, it was suggested that the inner disk is their most probable birthplace. Their chemical imprints may therefore reveal important information about the formation and evolution of the still poorly understood inner disk.Aims. To probe the formation history of these stellar populations, a detailed analysis of a sample of very metal-rich stars is carried out. We derive the metallicities, abundances of a elements, ages, and Galactic orbits.Methods. The analysis of 71 metal-rich stars is based on optical high-resolution echelle spectra obtained with the FEROS spectrograph at the ESO 1.52-m Telescope at La Silla, Chile. The metallicities and abundances of C, O, Mg, Si, Ca, and Ti were derived based on LTE detailed analysis, employing the MARCS model atmospheres.Results. We confirm the high metallicity of these stars reaching up to [Fe(I)/H] = 0.58, and the sample of metal-rich dwarfs can be kinematically subclassified in samples of thick disk, thin disk, and intermediate stellar populations. All sample stars show solar alpha-Fe ratios, and most of them are old and still quite metal rich. The orbits suggest that the thin disk, thick disk and intermediate populations were formed at Galactocentric distances of similar to 8 kpc, similar to 6 kpc, and similar to 7 kpc, respectively. The mean maximum height of the thick disk subsample of Z(max) similar to 380 pc, is lower than for typical thick disk stars. A comparison of a-element abundances of the sample stars with bulge stars shows that the oxygen is compatible with a bulge or inner thick disk origin. Our results suggest that models of radial mixing and dynamical effects of the bar and bar/spiral arms might explain the presence of these old metal-rich dwarf stars in the solar neighbourhood.
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| 8. |
- Trevisan, M., et al.
(författare)
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Metal rich stars in solar neighbourhood (Trevisan+, 2011)
- 2011
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Ingår i: VizieR Online Data Catalog. ; 353
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Tidskriftsartikel (refereegranskat)abstract
- Spectroscopic stellar parameters and abundances of C, O, Mg, Si, Ca, Ti and Ni for 71 stars. U, V, W velocities and orbital parameters derived using the GRINTON integrator (Carraro et al. 2002MNRAS.332..705C, Bedin et al. 2006A\ampA...460L..27B). Atomic data for Fe I, Fe II, Si I, Ca I, and Ti I lines. (7 data files).
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