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Sökning: WFRF:(Troyer M.) > (2020-2024)

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1.
  • Decuyper, J., et al. (författare)
  • A nonlinear model of vortex-induced forces on an oscillating cylinder in a fluid flow
  • 2020
  • Ingår i: Journal of Fluids and Structures. - : ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD. - 0889-9746 .- 1095-8622. ; 96
  • Tidskriftsartikel (refereegranskat)abstract
    • A nonlinear model relating the imposed motion of a circular cylinder, submerged in a fluid flow, to the transverse force coefficient is presented. The nonlinear fluid system, featuring vortex shedding patterns, limit cycle oscillations and synchronisation, is studied both for swept sine and multisine excitation. A nonparametric nonlinear distortion analysis (FAST) is used to distinguish odd from even nonlinear behaviour. The information which is obtained from the nonlinear analysis is explicitly used in constructing a nonlinear model of the polynomial nonlinear state-space (PNLSS) type. The latter results in a reduction of the number of parameters and an increased accuracy compared to the generic modelling approach where typically no such information of the nonlinearity is used. The obtained model is able to accurately simulate time series of the transverse force coefficient over a wide range of the frequency-amplitude plane of imposed cylinder motion. (C) 2020 Elsevier Ltd. All rights reserved.
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2.
  • Sanchez, Erlan, et al. (författare)
  • Association of plasma biomarkers with cognition, cognitive decline, and daily function across and within neurodegenerative diseases: Results from the Ontario Neurodegenerative Disease Research Initiative
  • 2024
  • Ingår i: Alzheimer's and Dementia. - 1552-5260 .- 1552-5279. ; 20:3, s. 1753-1770
  • Tidskriftsartikel (refereegranskat)abstract
    • INTRODUCTION: We investigated whether novel plasma biomarkers are associated with cognition, cognitive decline, and functional independence in activities of daily living across and within neurodegenerative diseases. METHODS: Glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau (p-tau)181 and amyloid beta (Aβ)42/40 were measured using ultra-sensitive Simoa immunoassays in 44 healthy controls and 480 participants diagnosed with Alzheimer's disease/mild cognitive impairment (AD/MCI), Parkinson's disease (PD), frontotemporal dementia (FTD) spectrum disorders, or cerebrovascular disease (CVD). RESULTS: GFAP, NfL, and/or p-tau181 were elevated among all diseases compared to controls, and were broadly associated with worse baseline cognitive performance, greater cognitive decline, and/or lower functional independence. While GFAP, NfL, and p-tau181 were highly predictive across diseases, p-tau181 was more specific to the AD/MCI cohort. Sparse associations were found in the FTD and CVD cohorts and for Aβ42/40. DISCUSSION: GFAP, NfL, and p-tau181 are valuable predictors of cognition and function across common neurodegenerative diseases, and may be useful in specialized clinics and clinical trials.
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