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Topical immunomodul...
Topical immunomodulators for management of oral mucosal conditions, a systematic review; Part II: miscellaneous agents.
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Elad, Sharon (författare)
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Epstein, Joel B (författare)
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- von Bültzingslöwen, Inger, 1947 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för odontologi,Institute of Odontology
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Drucker, Scott (författare)
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Tzach, Rinat (författare)
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Yarom, Noam (författare)
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(creator_code:org_t)
- 2011-01-19
- 2011
- Engelska.
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Ingår i: Expert opinion on emerging drugs. - : Informa Healthcare. - 1744-7623 .- 1472-8214. ; 16:1, s. 183-202
- Relaterad länk:
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- INTRODUCTION: Topical immunomodulating preparations have utility in inflammatory/immune-mediated oral mucosal disease resistant to topical steroids, in immunologically mediated systemic disease with primary oral involvement or more severe lesions primarily involving the oral mucosa. AREAS COVERED: This paper is the second part of a systematic review of a variety of topical immunomodulators for management of immune/inflammatory oral mucosal conditions. The literature search revealed studies of azathioprine, benzydamine, GM-CSF and G-CSF, tetracyclines, retinoids, imiquimod, amlexanox, sirolimus and bacillus Calmette-Guerin polysaccharide nucleic acid. Weighted conclusions are provided for the topical use of each of the immunomodulators reviewed in the management of these oral diseases. EXPERT OPINION: Topical immunomodulators may be useful as second line treatment in several oral diseases, particularly oral lichen planus and recurrent aphthous stomatitis. Benzydamine was found to be preventive in radiotherapy-induced mucositis; however, it is unclear if this outcome is related to its immunomodulating effects or other mechanisms of action. Topical application of tetracyclines and retinoic acid also shows potential anti-inflammatory actions.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Administration
- Topical
- Clinical Trials as Topic
- Drug Discovery
- methods
- Humans
- Immunologic Factors
- administration & dosage
- adverse effects
- therapeutic use
- Lichen Planus
- Oral
- drug therapy
- immunology
- Mouth Diseases
- drug therapy
- immunology
- Mouth Mucosa
- drug effects
- immunology
- Retinoids
- administration & dosage
- adverse effects
- therapeutic use
- Stomatitis
- Aphthous
- drug therapy
- immunology
- Tetracyclines
- administration & dosage
- adverse effects
- therapeutic use
- Treatment Outcome
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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