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- Umanskaya, A, et al.
(författare)
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Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging
- 2014
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Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 1091-6490. ; 111:42, s. 15250-15255
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Tidskriftsartikel (refereegranskat)abstract
- Age-related muscle weakness has major adverse consequences on quality of life, increasing the risk of falls, fractures, and movement impairments. Albeit an increased oxidative state has been shown to contribute to age-dependent reduction in skeletal muscle function, little is known about the mechanisms connecting oxidation and muscle weakness. We show here that genetically enhancing mitochondrial antioxidant activity causes improved skeletal muscle function and voluntary exercise in aged mice. Our findings have broad implications for both the aging and muscle physiology fields, as we present an important molecular mechanism for muscle weakness in aging and skeletal muscle force regulation.
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