| 1. |
- Alexander, Stephen P. H., et al.
(författare)
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The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
- 2023
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Ingår i: BRITISH JOURNAL OF PHARMACOLOGY. - : British pharmacological society. - 0007-1188 .- 1476-5381. ; 180
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Tidskriftsartikel (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at . G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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| 2. |
- Christopoulos, Arthur, et al.
(författare)
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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.
- 2021
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Ingår i: British journal of pharmacology. - : Wiley. - 1476-5381 .- 0007-1188. ; 178 Suppl 1
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Forskningsöversikt (refereegranskat)abstract
- The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
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| 3. |
- Anzt, Hartwig, et al.
(författare)
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An environment for sustainable research software in Germany and beyond: current state, open challenges, and call for action
- 2020
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Ingår i: F1000 Research. - : F1000 Research Ltd. - 2046-1402. ; 9
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Tidskriftsartikel (refereegranskat)abstract
- Research software has become a central asset in academic research. It optimizes existing and enables new research methods, implements and embeds research knowledge, and constitutes an essential research product in itself. Research software must be sustainable in order to understand, replicate, reproduce, and build upon existing research or conduct new research effectively. In other words, software must be available, discoverable, usable, and adaptable to new needs, both now and in the future. Research software therefore requires an environment that supports sustainability. Hence, a change is needed in the way research software development and maintenance are currently motivated, incentivized, funded, structurally and infrastructurally supported, and legally treated. Failing to do so will threaten the quality and validity of research. In this paper, we identify challenges for research software sustainability in Germany and beyond, in terms of motivation, selection, research software engineering personnel, funding, infrastructure, and legal aspects. Besides researchers, we specifically address political and academic decision-makers to increase awareness of the importance and needs of sustainable research software practices. In particular, we recommend strategies and measures to create an environment for sustainable research software, with the ultimate goal to ensure that software-driven research is valid, reproducible and sustainable, and that software is recognized as a first class citizen in research. This paper is the outcome of two workshops run in Germany in 2019, at deRSE19 - the first International Conference of Research Software Engineers in Germany - and a dedicated DFG-supported follow-up workshop in Berlin.
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| 4. |
- Bergmeister, Konstantin D, et al.
(författare)
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Peripheral nerve transfers change target muscle structure and function
- 2019
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Ingår i: Science advances. - : American Association for the Advancement of Science (AAAS). - 2375-2548. ; 5:1
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Tidskriftsartikel (refereegranskat)abstract
- Selective nerve transfers surgically rewire motor neurons and are used in extremity reconstruction to restore muscle function or to facilitate intuitive prosthetic control. We investigated the neurophysiological effects of rewiring motor axons originating from spinal motor neuron pools into target muscles with lower innervation ratio in a rat model. Following reinnervation, the target muscle's force regenerated almost completely, with the motor unit population increasing to 116% in functional and 172% in histological assessments with subsequently smaller muscle units. Muscle fiber type populations transformed into the donor nerve's original muscles. We thus demonstrate that axons of alternative spinal origin can hyper-reinnervate target muscles without loss of muscle force regeneration, but with a donor-specific shift in muscle fiber type. These results explain the excellent clinical outcomes following nerve transfers in neuromuscular reconstruction. They indicate that reinnervated muscles can provide an accurate bioscreen to display neural information of lost body parts for high-fidelity prosthetic control.
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| 5. |
- Eriksson, Marie, et al.
(författare)
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Avloppsvatten : Rening av avloppsvatten i Sverige
- 2016
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Utvecklingen de senaste 200 åren har gått från nedgrävda latriner via underjordiska kloaker som släpptes ut i närmaste sjö eller kustvatten till avancerade avloppsreningsverk. Avloppsfrågan har förändrats från att vara lösningen på ett lokalt sanitärt problem till att bli en global miljöfråga.Rening av avloppsvatten i Sverige ges ut av Naturvårdsverket och beskriver hur reningen av avloppsvatten från tätorter utvecklats i Sverige under 1900- och 2000-talen. Skriften ges ut vartannat år och har uppdaterats med senaste statistiken från 2014 angående utsläpp och slam från reningsverk.Informationen presenteras enligt artikel 16 i avloppsdirektivet (91/271/EEG). Direktivet omfattar allt avloppsvatten som samlas upp i ledningsnät, men kvantitativa krav ställs bara för de reningsverk som betjänar mer är 2 000 personer. I Sverige motsvarar det drygt 400 anläggningar. De gamla medlemsländerna i EU (EU15) skulle ha uppfyllt alla åtgärder inom ramen för direktivet vid utgången av 2005. De 12 nya EU-länderna har olika övergångsregler.
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| 6. |
- Kronander, Joel, 1983-, et al.
(författare)
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A unified framework for multi-sensor HDR video reconstruction
- 2014
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Ingår i: Signal Processing : Image Communications. - : Elsevier. - 0923-5965. ; 29:2, s. 203-215
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Tidskriftsartikel (refereegranskat)abstract
- One of the most successful approaches to modern high quality HDR-video capture is to use camera setups with multiple sensors imaging the scene through a common optical system. However, such systems pose several challenges for HDR reconstruction algorithms. Previous reconstruction techniques have considered debayering, denoising, resampling (alignment) and exposure fusion as separate problems. In contrast, in this paper we present a unifying approach, performing HDR assembly directly from raw sensor data. Our framework includes a camera noise model adapted to HDR video and an algorithm for spatially adaptive HDR reconstruction based on fitting of local polynomial approximations to observed sensor data. The method is easy to implement and allows reconstruction to an arbitrary resolution and output mapping. We present an implementation in CUDA and show real-time performance for an experimental 4 Mpixel multi-sensor HDR video system. We further show that our algorithm has clear advantages over existing methods, both in terms of flexibility and reconstruction quality.
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| 7. |
- Kronander, Joel, et al.
(författare)
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Real-time HDR video reconstruction for multi-sensor systems
- 2012
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Ingår i: ACM SIGGRAPH 2012 Posters. - New York, NY, USA : ACM Press. ; , s. 65-
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Konferensbidrag (refereegranskat)abstract
- HDR video is an emerging field of technology, with a few camera systems currently in existence [Myszkowski et al. 2008], Multi-sensor systems [Tocci et al. 2011] have recently proved to be particularly promising due to superior robustness against temporal artifacts, correct motion blur, and high light efficiency. Previous HDR reconstruction methods for multi-sensor systems have assumed pixel perfect alignment of the physical sensors. This is, however, very difficult to achieve in practice. It may even be the case that reflections in beam splitters make it impossible to match the arrangement of the Bayer filters between sensors. We therefor present a novel reconstruction method specifically designed to handle the case of non-negligible misalignments between the sensors. Furthermore, while previous reconstruction techniques have considered HDR assembly, debayering and denoising as separate problems, our method is capable of simultaneous HDR assembly, debayering and smoothing of the data (denoising). The method is also general in that it allows reconstruction to an arbitrary output resolution and mapping. The algorithm is implemented in CUDA, and shows video speed performance for an experimental HDR video platform consisting of four 2336x1756 pixels high quality CCD sensors imaging the scene trough a common optical system. ND-filters of different densities are placed in front of the sensors to capture a dynamic range of 24 f-stops.
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| 8. |
- Kronander, Joel, et al.
(författare)
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Unified HDR reconstruction from raw CFA data
- 2013
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Ingår i: Proceedings of IEEE International Conference on Computational Photography 2013. - : IEEE. - 9781467364638 ; , s. 1-9
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Konferensbidrag (refereegranskat)abstract
- HDR reconstruction from multiple exposures poses several challenges. Previous HDR reconstruction techniques have considered debayering, denoising, resampling (alignment) and exposure fusion in several steps. We instead present a unifying approach, performing HDR assembly directly from raw sensor data in a single processing operation. Our algorithm includes a spatially adaptive HDR reconstruction based on fitting local polynomial approximations to observed sensor data, using a localized likelihood approach incorporating spatially varying sensor noise. We also present a realistic camera noise model adapted to HDR video. The method allows reconstruction to an arbitrary resolution and output mapping. We present an implementation in CUDA and show real-time performance for an experimental 4 Mpixel multi-sensor HDR video system. We further show that our algorithm has clear advantages over state-of-the-art methods, both in terms of flexibility and reconstruction quality.
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| 9. |
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| 10. |
- Unger, Jonas, 1978-, et al.
(författare)
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A Real Time Light Probe
- 2004
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Ingår i: The 25th Eurographics Annual Conference 2004 Short papers and Interactive Applications, Grenoble, France.
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Konferensbidrag (refereegranskat)abstract
- We present a novel system capable of capturing high dynamic range (HDR) Light Probes at video speed. Each Light Probe frame is built from an individual full set of exposures, all of which are captured within the frame time. The exposures are processed and assembled into a mantissa-exponent representation image within the camera unit before output, and then streamed to a standard PC. As an example, the system is capable of capturing Light Probe Images with a resolution of 512x512 pixels using a set of 10 exposures covering 15 f-stops at a frame rate of up to 25 final HDR frames per second. The system is built around commercial special-purpose camera hardware with on-chip programmable image processing logic and tightly integrated frame buffer memory, and the algorithm is implemented as custom downloadable microcode software.
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