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Brain Changes Induc...
Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
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- Ousdal, Olga Therese (author)
- Haukeland Hosp, Norway
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- Argyelan, Miklos (author)
- Feinstein Inst Med Res, NY USA
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- Narr, Katherine L. (author)
- Univ Calif Los Angeles, CA 90024 USA
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- Abbott, Christopher (author)
- Univ New Mexico, NM 87131 USA
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- Wade, Benjamin (author)
- Univ Calif Los Angeles, CA 90024 USA
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- Vandenbulcke, Mathieu (author)
- Katholieke Univ Leuven, Belgium
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- Urretavizcaya, Mikel (author)
- Univ Barcelona, Spain; Univ Barcelona, Spain; Carlos III Hlth Inst, Spain
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- Tendolkar, Indira (author)
- Radboud Univ Nijmegen, Netherlands; Ctr Cognit Neuroimaging, Netherlands; Univ Duisburg Essen, Germany; Univ Duisburg Essen, Germany
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- Takamiya, Akihiro (author)
- Keio Univ, Japan; Komagino Hosp, Japan
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- Stek, Max L. (author)
- Geestelijke GezondheidsZorg InGeest Specialized M, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Soriano-Mas, Carles (author)
- Univ Barcelona, Spain; Univ Autonoma Barcelona, Spain; Carlos III Hlth Inst, Spain
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- Redlich, Ronny (author)
- Univ Munster, Germany
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- Paulson, Olaf B. (author)
- Rigshosp, Denmark; Univ Copenhagen, Denmark
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- Oudega, Mardien L. (author)
- Geestelijke GezondheidsZorg InGeest Specialized M, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Opel, Nils (author)
- Univ Munster, Germany; Univ Munster, Germany
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- Nordanskog, Pia, 1971- (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten,Region Östergötland, Psykiatriska kliniken i Linköping
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- Kishimoto, Taishiro (author)
- Keio Univ, Japan
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- Kämpe, Robin (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Jorgensen, Anders (author)
- Rigshosp, Denmark
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- Hanson, Lars G. (author)
- Tech Univ Denmark, Denmark; Copenhagen Univ Hosp, Denmark
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- Hamilton, Paul (author)
- Linköpings universitet,Centrum för social och affektiv neurovetenskap,Medicinska fakulteten
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- Espinoza, Randall (author)
- Univ Calif Los Angeles, CA 90024 USA
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- Emsell, Louise (author)
- Katholieke Univ Leuven, Belgium
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- van Eijndhoven, Philip (author)
- Radboud Univ Nijmegen, Netherlands; Ctr Cognit Neuroimaging, Netherlands
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- Dols, Annemieke (author)
- Geestelijke GezondheidsZorg InGeest Specialized M, Netherlands; Vrije Univ Amsterdam, Netherlands
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- Dannlowski, Udo (author)
- Univ Munster, Germany
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- Cardoner, Narcis (author)
- Univ Autonoma Barcelona, Spain; Carlos III Hlth Inst, Spain; Univ Hosp Parc Tauli I3PT, Spain
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- Bouckaert, Filip (author)
- Katholieke Univ Leuven, Belgium
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- Anand, Amit (author)
- Cleveland Clin, OH 44106 USA
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- Bartsch, Hauke (author)
- Univ Calif Los Angeles, CA USA; Ctr Multimodal Imaging and Genet, CA USA; Univ Calif San Diego, CA 92093 USA
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- Kessler, Ute (author)
- Haukeland Hosp, Norway; Univ Bergen, Norway
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- Oedegaard, Ketil J. (author)
- Haukeland Hosp, Norway; Univ Bergen, Norway
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- Dale, Anders M. (author)
- Univ Calif Los Angeles, CA USA; Ctr Multimodal Imaging and Genet, CA USA; Univ Calif San Diego, CA 92093 USA; Univ Calif San Diego, CA 92093 USA
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- Oltedal, Leif (author)
- Haukeland Hosp, Norway; Univ Bergen, Norway
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- English.
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In: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 87:5, s. 451-461
- Related links:
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https://liu.diva-por... (primary) (Raw object)
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http://www.biologica...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohens d = 1.01, p amp;lt; .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p amp;lt; .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearmans rank correlation rho = -.44, p amp;lt; .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Antidepressant; Biomarker; Brain; Depression; ECT; Magnetic resonance imaging; Neuroimaging
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ousdal, Olga The ...
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Argyelan, Miklos
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Narr, Katherine ...
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Abbott, Christop ...
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Wade, Benjamin
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Vandenbulcke, Ma ...
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show more...
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Urretavizcaya, M ...
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Tendolkar, Indir ...
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Takamiya, Akihir ...
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Stek, Max L.
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Soriano-Mas, Car ...
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Redlich, Ronny
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Paulson, Olaf B.
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Oudega, Mardien ...
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Opel, Nils
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Nordanskog, Pia, ...
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Kishimoto, Taish ...
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Kämpe, Robin
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Jorgensen, Ander ...
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Hanson, Lars G.
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Hamilton, Paul
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Espinoza, Randal ...
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Emsell, Louise
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van Eijndhoven, ...
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Dols, Annemieke
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Dannlowski, Udo
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Cardoner, Narcis
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Bouckaert, Filip
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Anand, Amit
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Bartsch, Hauke
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Kessler, Ute
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Oedegaard, Ketil ...
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Dale, Anders M.
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Oltedal, Leif
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Biological Psych ...
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Linköping University