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- Bousquet, J, et al.
(författare)
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Nrf2-interacting nutrients and COVID-19: time for research to develop adaptation strategies
- 2020
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Ingår i: Clinical and translational allergy. - : Wiley. - 2045-7022. ; 10:1, s. 58-
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Tidskriftsartikel (refereegranskat)abstract
- There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPARγ:Peroxisome proliferator-activated receptor, NFκB: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2α:Elongation initiation factor 2α). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT1R axis (AT1R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity.
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| 2. |
- Imai, H., et al.
(författare)
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FLASHING: New high-velocity H2O masers in IRAS 18286−0959
- 2020
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Ingår i: Publication of the Astronomical Society of Japan. - : Oxford University Press (OUP). - 2053-051X .- 0004-6264. ; 72:4
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Tidskriftsartikel (refereegranskat)abstract
- We discovered new high-velocity components of H2O maser emission in one of the “water fountain” sources, IRAS 18286−0959, which has been monitored using the Nobeyama 45 m telescope in the FLASHING (Finest Legacy Acquisitions of SiO- and H2O-maser Ignitions by Nobeyama Generation) project since 2018 December. The maser spectra show new components with extremely high expansion velocities (>200 km s−1 projected in the line of sight), some of which are located symmetrically in the spectrum with respect to the systemic velocity. They were also mapped with KaVA (KVN and VERA Combined Array) in 2019 March. We located some of these maser components closer to the central stellar system than other high-velocity components (50-200 km s−1) that have been confirmed to be associated with the known bipolar outflow. The new components would have flashed in the fast collimated jet at a speed of over 300 km s−1 (soon) after 2011 when they had not been detected. The fastest of the new components seem to indicate rapid deceleration in these spectra; however, our present monitoring is still too sparse to unambiguously confirm it (up to 50 km s−1 yr−1) and too short to reveal their terminal expansion velocity, which will be equal to the expansion velocity that has been observed (vexp ∼ 120 km s−1). Future occurrences of such extreme-velocity components may provide a good opportunity to investigate possible recurrent outflow ignitions. Thus, the sculpture of the parental envelope will be traced by the dense gas that is entrained by the fast jet and exhibits spectacular distributions of the relatively stable maser features.
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