| 1. |
|
|
| 2. |
- Gladush, G. G., et al.
(författare)
-
Studying the mechanisms of steel sheet perforation by the radiation of a continuous-wave fiber laser
- 2016
-
Ingår i: Bulletin of the Russian Academy of Sciences: Physics. - 1062-8738 .- 1934-9432. ; 80:4, s. 393-396
-
Tidskriftsartikel (refereegranskat)abstract
- Aspects of steel sheet perforation are studied experimentally. Calculations show that the mechanisms of thin sheet perforation change as the focal spot size is increased at a constant laser power. If the spot is small, the melt is removed and the film is disrupted by steel boiling in the spot center. With larger spots, the melt is removed by the force of gravity. The hole diameter grows along with the focal spot size and sheet thickness and is reduced upon an increase in laser power.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Sclafani, F., et al.
(författare)
-
Prognostic role of the LCS6 KRAS variant in locally advanced rectal cancer : results of the EXPERT-C trial
- 2015
-
Ingår i: Annals of Oncology. - : Elsevier BV. - 0923-7534 .- 1569-8041. ; 26:9, s. 1936-1941
-
Tidskriftsartikel (refereegranskat)abstract
- Lethal-7 (let-7) is a tumour suppressor miRNA which acts by down-regulating several oncogenes including KRAS. A single-nucleotide polymorphism (rs61764370, T > G base substitution) in the let-7 complementary site 6 (LCS-6) of KRAS mRNA has been shown to predict prognosis in early-stage colorectal cancer (CRC) and benefit from anti-epidermal growth factor receptor monoclonal antibodies in metastatic CRC. We analysed rs61764370 in EXPERT-C, a randomised phase II trial of neoadjuvant CAPOX followed by chemoradiotherapy, surgery and adjuvant CAPOX plus or minus cetuximab in locally advanced rectal cancer. DNA was isolated from formalin-fixed paraffin-embedded tumour tissue and genotyped using a PCR-based commercially available assay. Kaplan-Meier method and Cox regression analysis were used to calculate survival estimates and compare treatment arms. A total of 155/164 (94.5%) patients were successfully analysed, of whom 123 (79.4%) and 32 (20.6%) had the LCS-6 TT and LCS-6 TG genotype, respectively. Carriers of the G allele were found to have a statistically significantly higher rate of complete response (CR) after neoadjuvant therapy (28.1% versus 10.6%; P = 0.020) and a trend for better 5-year progression-free survival (PFS) [77.4% versus 64.5%: hazard ratio (HR) 0.56; P = 0.152] and overall survival (OS) rates (80.3% versus 71.9%: HR 0.59; P = 0.234). Both CR and survival outcomes were independent of the use of cetuximab. The negative prognostic effect associated with KRAS mutation appeared to be stronger in patients with the LCS-6 TT genotype (HR PFS 1.70, P = 0.078; HR OS 1.79, P = 0.082) compared with those with the LCS-6 TG genotype (HR PFS 1.33, P = 0.713; HR OS 1.01, P = 0.995). This analysis suggests that rs61764370 may be a biomarker of response to neoadjuvant treatment and an indicator of favourable outcome in locally advanced rectal cancer possibly by mitigating the poor prognosis of KRAS mutation. In this setting, however, this polymorphism does not appear to predict cetuximab benefit.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Kovtun, Oleksiy, et al.
(författare)
-
Spin-orbit interaction in bremsstrahlung and its effect on the electron motion in a strong Coulomb field
- 2015
-
Ingår i: Physical Review A. Atomic, Molecular, and Optical Physics. - : American Physical Society. - 1050-2947 .- 1094-1622. ; 92:6
-
Tidskriftsartikel (refereegranskat)abstract
- Linear polarization of bremsstrahlung x rays produced in collisions of longitudinally polarized 2.1-MeV electrons with gold atoms was studied using the Compton scattering technique. We observed that the angle of x-ray polarization is strongly correlated with the incoming electron polarization. This correlation reveals the dominance of the spin-orbit interaction in bremsstrahlung and indicates a striking effect of the electron spin on the electron motion in a strong Coulomb field. The results confirm the validity of the theoretical predictions in a computationally challenging energy regime.
|
|
| 9. |
- Saag, Lehti, et al.
(författare)
-
The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East
- 2019
-
Ingår i: Current Biology. - : Elsevier BV. - 0960-9822 .- 1879-0445. ; 29:10, s. 1701-
-
Tidskriftsartikel (refereegranskat)abstract
- In this study, we compare the genetic ancestry of individuals from two as yet genetically unstudied cultural traditions in Estonia in the context of available modern and ancient datasets: 15 from the Late Bronze Age stone-cist graves (1200-400 BC) (EstBA) and 6 from the Pre-Roman Iron Age tarand cemeteries (800/500 BC-50 AD) (EstIA). We also included 5 Pre-Roman to Roman Iron Age Ingrian (500 BC450 AD) (IngIA) and 7 Middle Age Estonian (1200-1600 AD) (EstMA) individuals to build a dataset for studying the demographic history of the northern parts of the Eastern Baltic from the earliest layer of Mesolithic to modern times. Our findings are consistent with EstBA receiving gene flow from regions with strong Western hunter-gatherer (WHG) affinities and EstIA from populations related to modern Siberians. The latter inference is in accordance with Y chromosome (chrY) distributions in present day populations of the Eastern Baltic, as well as patterns of autosomal variation in the majority of the westernmost Uralic speakers [1-5]. This ancestry reached the coasts of the Baltic Sea no later than the mid-first millennium BC; i.e., in the same time window as the diversification of west Uralic (Finnic) languages [6]. Furthermore, phenotypic traits often associated with modern Northern Europeans, like light eyes, hair, and skin, as well as lactose tolerance, can be traced back to the Bronze Age in the Eastern Baltic.
|
|
