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| 2. |
- Barausse, Enrico, et al.
(författare)
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Prospects for fundamental physics with LISA
- 2020
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Ingår i: General Relativity and Gravitation. - : SPRINGER/PLENUM PUBLISHERS. - 0001-7701 .- 1572-9532. ; 52:8
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- In this paper, which is of programmatic rather than quantitative nature, we aim to further delineate and sharpen the future potential of the LISA mission in the area of fundamental physics. Given the very broad range of topics that might be relevant to LISA,we present here a sample of what we view as particularly promising fundamental physics directions. We organize these directions through a "science-first" approach that allows us to classify how LISA data can inform theoretical physics in a variety of areas. For each of these theoretical physics classes, we identify the sources that are currently expected to provide the principal contribution to our knowledge, and the areas that need further development. The classification presented here should not be thought of as cast in stone, but rather as a fluid framework that is amenable to change with the flow of new insights in theoretical physics.
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| 3. |
- Stroth, U., et al.
(författare)
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Progress from ASDEX Upgrade experiments in preparing the physics basis of ITER operation and DEMO scenario development
- 2022
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 1741-4326 .- 0029-5515. ; 62:4
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Tidskriftsartikel (refereegranskat)abstract
- An overview of recent results obtained at the tokamak ASDEX Upgrade (AUG) is given. A work flow for predictive profile modelling of AUG discharges was established which is able to reproduce experimental H-mode plasma profiles based on engineering parameters only. In the plasma center, theoretical predictions on plasma current redistribution by a dynamo effect were confirmed experimentally. For core transport, the stabilizing effect of fast ion distributions on turbulent transport is shown to be important to explain the core isotope effect and improves the description of hollow low-Z impurity profiles. The L-H power threshold of hydrogen plasmas is not affected by small helium admixtures and it increases continuously from the deuterium to the hydrogen level when the hydrogen concentration is raised from 0 to 100%. One focus of recent campaigns was the search for a fusion relevant integrated plasma scenario without large edge localised modes (ELMs). Results from six different ELM-free confinement regimes are compared with respect to reactor relevance: ELM suppression by magnetic perturbation coils could be attributed to toroidally asymmetric turbulent fluctuations in the vicinity of the separatrix. Stable improved confinement mode plasma phases with a detached inner divertor were obtained using a feedback control of the plasma β. The enhanced D α H-mode regime was extended to higher heating power by feedback controlled radiative cooling with argon. The quasi-coherent exhaust regime was developed into an integrated scenario at high heating power and energy confinement, with a detached divertor and without large ELMs. Small ELMs close to the separatrix lead to peeling-ballooning stability and quasi continuous power exhaust. Helium beam density fluctuation measurements confirm that transport close to the separatrix is important to achieve the different ELM-free regimes. Based on separatrix plasma parameters and interchange-drift-Alfvén turbulence, an analytic model was derived that reproduces the experimentally found important operational boundaries of the density limit and between L- and H-mode confinement. Feedback control for the X-point radiator (XPR) position was established as an important element for divertor detachment control. Stable and detached ELM-free phases with H-mode confinement quality were obtained when the XPR was moved 10 cm above the X-point. Investigations of the plasma in the future flexible snow-flake divertor of AUG by means of first SOLPS-ITER simulations with drifts activated predict beneficial detachment properties and the activation of an additional strike point by the drifts.
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| 4. |
- Bernstein, A., et al.
(författare)
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Fully-Dynamic Graph Sparsifiers Against an Adaptive Adversary
- 2022
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Ingår i: 49th International Colloquium on Automata, Languages, and Programming (ICALP 2022). - : Schloss Dagstuhl- Leibniz-Zentrum fur Informatik GmbH, Dagstuhl Publishing.
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Konferensbidrag (refereegranskat)abstract
- Designing efficient dynamic graph algorithms against an adaptive adversary is a major goal in the field of dynamic graph algorithms and has witnessed many exciting recent developments in, e.g., dynamic matching (Wajc STOC'20) and decremental shortest paths (Chuzhoy and Khanna STOC'19). Compared to other graph primitives (e.g. spanning trees and matchings), designing such algorithms for graph spanners and (more broadly) graph sparsifiers poses a unique challenge since there is no fast deterministic algorithm known for static computation and the lack of a way to adjust the output slowly (known as “small recourse/replacements”). This paper presents the first non-trivial efficient adaptive algorithms for maintaining many sparsifiers against an adaptive adversary. Specifically, we present algorithms that maintain 1. a polylog(n)-spanner of size Õ(n) in polylog(n) amortized update time, 2. an O(k)-approximate cut sparsifier of size Õ(n) in Õ(n1/k) amortized update time, and 3. a polylog(n)-approximate spectral sparsifier in polylog(n) amortized update time. Our bounds are the first non-trivial ones even when only the recourse is concerned. Our results hold even against a stronger adversary, who can access the random bits previously used by the algorithms and the amortized update time of all algorithms can be made worst-case by paying sub-polynomial factors. Our spanner result resolves an open question by Ahmed et al. (2019) and our results and techniques imply additional improvements over existing results, including (i) answering open questions about decremental single-source shortest paths by Chuzhoy and Khanna (STOC'19) and Gutenberg and Wulff-Nilsen (SODA'20), implying a nearly-quadratic time algorithm for approximating minimum-cost unit-capacity flow and (ii) de-amortizing a result of Abraham et al. (FOCS'16) for dynamic spectral sparsifiers. Our results are based on two novel techniques. The first technique is a generic black-box reduction that allows us to assume that the graph is initially an expander with almost uniform-degree and, more importantly, stays as an almost uniform-degree expander while undergoing only edge deletions. The second technique is called proactive resampling: here we constantly re-sample parts of the input graph so that, independent of an adversary's computational power, a desired structure of the underlying graph can be always maintained. Despite its simplicity, the analysis of this sampling scheme is far from trivial, because the adversary can potentially create dependencies between the random choices used by the algorithm. We believe these two techniques could be useful for developing other adaptive algorithms.
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| 6. |
- Stanworth, Simon J, et al.
(författare)
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The EHA Research Roadmap : Transfusion Medicine
- 2022
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Ingår i: HemaSphere. - : Ovid Technologies (Wolters Kluwer Health). - 2572-9241. ; 6:2, s. 1-6
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Tidskriftsartikel (refereegranskat)abstract
- In 2016, the European Hematology Association (EHA) published the EHA Roadmap for European Hematology Research1 aiming to highlight achievements in the diagnostics and treatment of blood disorders, and to better inform European policy makers and other stakeholders about the urgent clinical and scientific needs and priorities in the field of hematology. Each section was coordinated by 1–2 section editors who were leading international experts in the field. In the 5 years that have followed, advances in the field of hematology have been plentiful. As such, EHA is pleased to present an updated Research Roadmap, now including eleven sections, each of which will be published separately. The updated EHA Research Roadmap identifies the most urgent priorities in hematology research and clinical science, therefore supporting a more informed, focused, and ideally a more funded future for European hematology research. The 11 EHA Research Roadmap sections include Normal Hematopoiesis; Malignant Lymphoid Diseases; Malignant Myeloid Diseases; Anemias and Related Diseases; Platelet Disorders; Blood Coagulation and Hemostatic Disorders; Transfusion Medicine; Infections in Hematology; Hematopoietic Stem Cell Transplantation; CAR-T and Other Cell-based Immune Therapies; and Gene Therapy.
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