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Female mice lacking...
Female mice lacking Pald1 exhibit endothelial cell apoptosis and emphysema
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- Egana, I (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Kaito, H (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Nitzsche, Anja (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab,Mats Hellström
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- Becker, L (author)
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany
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- Ballester-Lopez, C (author)
- German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Expt Genet, German Mouse Clin, Neuherberg, Germany.; German Ctr Lung Res DZL, Comprehens Pneumol Ctr, Helmholtz Zentrum Munchen, Inst Lung Biol & Dis,German Res Ctr Environm Hlth, Munich, Germany
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- Niaudet, Colin (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Petkova, Milena (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Liu, W (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Vanlandewijck, M (author)
- Uppsala universitet,Karolinska Institutet,Institutionen för immunologi, genetik och patologi
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- Vernaleken, A (author)
- German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, Inst Expt Genet, German Mouse Clin, Neuherberg, Germany.; Ludwig Maximilians Univ Munchen, Friedrich Baur Inst, Dept Neurol, Munich, Germany
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- Klopstock, T (author)
- Department of Neurology, Friedrich-Baur-Institut, Ludwig-Maximilians-Universität München, Munich, Germany.; German Center for Vertigo and Balance Disorders, Munich, Germany.; Deutsches Zentrum für Neurodegenerative Erkrankungen e. V. (DZNE), Munich, Germany.; German Network for Mitochondrial Disorders (mitoNET), Munich, Germany
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- Fuchs, H (author)
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
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- Gailus-Durner, V (author)
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany
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- Hellström, Mats (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Rask-Andersen, Helge (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper
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- Johansson, HJ (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Canc Prote Mass Spectrometry, Stockholm, Sweden
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- Lehtio, J (author)
- Karolinska Institutet,Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Canc Prote Mass Spectrometry, Stockholm, Sweden
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- He, Liqun (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Yildirim, AO (author)
- German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany.; Comprehensive Pneumology Center, Institute of Lung Biology and Disease, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), The German Center for Lung Research (DZL), Munich, Germany
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Hellstrom, M (author)
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(creator_code:org_t)
- 2017-11-13
- 2017
- English.
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7:1, s. 15453-
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https://doi.org/10.1...
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Abstract
Subject headings
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- Paladin (Pald1, mKIAA1274 or x99384) was identified in screens for vascular-specific genes and is a putative phosphatase. Paladin has also been proposed to be involved in various biological processes such as insulin signaling, innate immunity and neural crest migration. To determine the role of paladin we have now characterized the Pald1 knock-out mouse in a broad array of behavioral, physiological and biochemical tests. Here, we show that female, but not male, Pald1 heterozygous and homozygous knock-out mice display an emphysema-like histology with increased alveolar air spaces and impaired lung function with an obstructive phenotype. In contrast to many other tissues where Pald1 is restricted to the vascular compartment, Pald1 is expressed in both the epithelial and mesenchymal compartments of the postnatal lung. However, in Pald1 knock-out females, there is a specific increase in apoptosis and proliferation of endothelial cells, but not in non-endothelial cells. This results in a transient reduction of endothelial cells in the maturing lung. Our data suggests that Pald1 is required during lung vascular development and for normal function of the developing and adult lung in a sex-specific manner. To our knowledge, this is the first report of a sex-specific effect on endothelial cell apoptosis.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Egana, I
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Kaito, H
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Nitzsche, Anja
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Becker, L
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Ballester-Lopez, ...
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Niaudet, Colin
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show more...
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Petkova, Milena
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Liu, W
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Vanlandewijck, M
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Vernaleken, A
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Klopstock, T
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Fuchs, H
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Gailus-Durner, V
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Hellström, Mats
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Rask-Andersen, H ...
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Johansson, HJ
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Lehtio, J
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He, Liqun
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Yildirim, AO
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Hellstrom, M
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Scientific repor ...
- By the university
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Karolinska Institutet
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Uppsala University