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Orally administered...
Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice
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- Salmenkari, H. (författare)
- Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
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- Holappa, M. (författare)
- Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
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- Forsgård, Richard A., 1987- (författare)
- Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
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- Korpela, R. (författare)
- Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
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- Vapaatalo, H. (författare)
- Faculty of Medicine, Pharmacology, University of Helsinki, Helsinki, Finland
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(creator_code:org_t)
- Polish Physiological Society, 2017
- 2017
- Engelska.
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Ingår i: Journal of Physiology and Pharmacology. - : Polish Physiological Society. - 0867-5910 .- 1899-1505. ; 68:3, s. 355-362
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The effects of angiotensin-converting enzyme (ACE) inhibition by an antihypertensive drug, captopril, and milk casein-derived ACE-inhibiting bioactive tripeptide isoleucine-proline-proline (Ile-Pro-Pro), on local renin-angiotensin system (RAS) and glucocorticoid production in the intestine were studied in the dextran sodium sulfate induced colitis in mice. Mice received water or 3% dextran sodium sulfate with or without either 15.7 mg/l captopril or 833 mg/l Ile-Pro-Pro for 7 days. Captopril and Ile-Pro-Pro were found to have distinct effects on local renin-angiotensin system and mRNA expression of glucocorticoid synthesis components in colon in vitro. Captopril reduced intestinal mRNA expression of angiotensin-converting enzyme, angiotensinogen and Cyp11b1, whereas Ile-Pro-Pro reduced angiotensin-converting enzyme protein shedding from colon. Neither captopril nor Ile-Pro-Pro changed the expression of glucocorticoid-synthesis driving transcription factor Lrh-1 expression or intestinal glucocorticoid production. Contrary to previous studies, captopril did not alleviate DSS-induced colitis. Furthermore, Ile-Pro-Pro was mildly pro-inflammatory as exhibited by increased pro-inflammatory cytokine interleukin-1 beta (IL-1 beta) and tumor necrosis factor-alpha (TNF-alpha) levels in colon. The nutritional component Ile-Pro-Pro had different effect on intestinal RAS and glucocorticoid (GC) synthesis pathway than ACE inhibitor captopril, which suggests that the bioactivity of Ile-Pro-Pro is not limited to inhibition of ACE.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Nyckelord
- angiotensin-converting enzyme
- glucocorticoid synthesis
- dextran sodium sulfate colitis
- isoleucine-proline-proline
- captopril
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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