| 1. |
- Wild, W., et al.
(författare)
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Millimetron—a large Russian-European submillimeter space observatory
- 2009
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Ingår i: Experimental Astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:1, s. 221-244
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Tidskriftsartikel (refereegranskat)abstract
- Millimetron is a Russian-led 12 m diameter submillimeter and far-infrared space observatory which is included in the Space Plan of the Russian Federation for launch around 2017. With its large collecting area and state-of-the-art receivers, it will enable unique science and allow at least one order of magnitude improvement with respect to the Herschel Space Observatory. Millimetron will be operated in two basic observing modes: as a single-dish observatory, and as an element of a ground-space very long baseline interferometry (VLBI) system. As single-dish, angular resolutions on the order of 3 to 12 arc sec will be achieved and spectral resolutions of up to a million employing heterodyne techniques. As VLBI antenna, the chosen elliptical orbit will provide extremely large VLBI baselines (beyond 300,000 km) resulting in micro-arc second angular resolution.
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| 2. |
- Hoots, W. K., et al.
(författare)
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Secondary prophylaxis with recombinant activated factor VII improves health-related quality of life of haemophilia patients with inhibitors
- 2008
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Ingår i: Haemophilia. - : Wiley. - 1351-8216 .- 1365-2516. ; 14:3, s. 466-466
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Tidskriftsartikel (refereegranskat)abstract
- Haemophilia patients with inhibitors characteristically have impaired joint function and reduced health-related quality of life (HRQoL). This analysis examined whether secondary prophylaxis with recombinant activated factor VII (rFVIIa) improves HRQoL vs. conventional on-demand therapy in patients with haemophilia with inhibitors and frequent bleeds. After a 3-month preprophylaxis period, 22 patients received daily rFVIIa prophylaxis (90 or 270 mu g kg(-1)) for 3 months, followed by 3 months' postprophylaxis. Days of hospitalization, absence from school/work and mobility aids requirements were recorded. HRQoL was assessed by EuroQoL (EQ-5D) questionnaire, visual analogue scale (VAS), derived Time to Trade-Off (TTO) scores and Quality Adjusted Life Years (QALYs). rFVIIa prophylaxis significantly (P < 0.0001) reduced bleeding frequency vs. prior on-demand therapy. Hospitalization (5.9% vs. 13.5%; P = 0.0026) and absenteeism from school/work (16.7% vs. 38.7%; P = 0.0127) decreased during prophylaxis; these effects tended to be maintained during postprophylaxis. HRQoL (evaluated by EQ-5D) tended to improve during and after rFVIIa prophylaxis. Notably, pain decreased and mobility increased in 40.9% and 27.3% of patients, respectively, at the end of the postprophylaxis period vs. preprophylaxis. Median VAS score increased from 66 to 73 (P = 0.048), and TTO scores suggested better HRQoL (0.62 vs. 0.76; P = 0.054) during postprophylaxis than preprophylaxis. Small to moderate changes in effect sizes were reported for VAS and TTO scores. Median QALYs were 0.68 (VAS) and 0.73 (TTO). Reductions in bleeding frequency with secondary rFVIIa prophylaxis were associated with improved HRQoL vs. on-demand therapy.
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| 3. |
- Krasilnikov, A. V., et al.
(författare)
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Fundamental ion cyclotron resonance heating of JET deuterium plasmas
- 2009
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Ingår i: Plasma Physics and Controlled Fusion. - : IOP Publishing. - 0741-3335 .- 1361-6587. ; 51:4, s. 044005-
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Tidskriftsartikel (refereegranskat)abstract
- Radio frequency heating of majority ions is of prime importance for understanding the basic role of auxiliary heating in the activated D-T phase of ITER. Majority deuterium ion cyclotron resonance heating (ICRH) experiments at the fundamental cyclotron frequency were performed in JET. In spite of the poor antenna coupling at 25 MHz, this heating scheme proved promising when adopted in combination with D neutral beam injection (NBI). The effect of fundamental ICRH of a D population was clearly demonstrated in these experiments: by adding similar to 25% of heating power the fusion power was increased up to 30-50%, depending on the type of NBI adopted. At this power level, the ion and electron temperatures increased from T-i similar to 4.0 keV and T-e similar to 4.5 keV (NBI-only phase) to T-i similar to 5.5 keV and T-e similar to 5.2 keV (ICRH + NBI phase), respectively. The increase in the neutron yield was stronger when 80 keV rather than 130 keV deuterons were injected in the plasma. It is shown that the neutron rate, the diamagnetic energy and the electron as well as the ion temperature scale roughly linearly with the applied RF power. A synergistic effect of the combined use of ICRF and NBI heating was observed: (i) the number of neutron counts measured by the neutron camera during the combined ICRF + NBI phases of the discharges exceeded the sum of the individual counts of the NBI-only and ICRF-only phases; (ii) a substantial increase in the number of slowing-down beam ions was detected by the time of flight neutron spectrometer when ICRF power was switched on; (iii) a small D subpopulation with energies slightly above the NBI launch energy was detected by the neutral particle analyzer and gamma-ray spectroscopy.
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