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Initial sequence of...
Initial sequence of the chimpanzee genome and comparison with the human genome
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- Mikkelsen, Tarjei (författare)
- Broad Institute
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- Hillier, LaDeana (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Eichler, Evan (författare)
- University of Washington, Department of Genome Sciences
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visa fler...
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- Zody, Michael, 1968- (författare)
- Broad Institute
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- Jaffe, David (författare)
- Broad Institute
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- Yang, Shiaw-Pyng (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Enard, Wolfgang (författare)
- Max Planck Institute of Evolutionary Anthropology
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- Hellmann, Ines (författare)
- Max Planck Institute of Evolutionary Anthropology
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- Lindblad-Toh, Kerstin (författare)
- Broad Institute
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- Altheide, Tasha (författare)
- University of California, San Diego
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- Archidiacono, Nicoletta (författare)
- University of Bari, Department of Genetics and Microbiology
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- Bork, Peer (författare)
- EMBL
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- Butler, Jonathan (författare)
- Broad Institute
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- Chang, Jean (författare)
- Broad Institute
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- Cheng, Ze (författare)
- University of Washington, Department of Genome Sciences
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- Chinwalla, Asif (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- de Jong, Pieter (författare)
- Children's Hospital Oakland Research Institute
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- Delehaunty, Kimberley (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Fronick, Catrina (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Fulton, Lucinda (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Gilad, Yoav (författare)
- Yale University School of Medicine, Department of Genetics
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- Glusman, Gustavo (författare)
- Institute for Systems Biology
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- Gnerre, Sante (författare)
- Broad Institute
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- Graves, Tina (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Hayakawa, Toshiyuki (författare)
- University of California, San Diego
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- Hayden, Karen (författare)
- Case Western Reserve University, Department of Genetics
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- Huang, Xiaoqiu (författare)
- Iowa State University, Department of Computer Science
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- Ji, Hongkai (författare)
- Harvard University, Department of Statistics
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- Kent, W. (författare)
- University of California, Santa Cruz, Center for Biomolecular Science and Engineering
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- King, Mary-Claire (författare)
- University of Washington, Department of Genome Sciences
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- Kulbokas, Edward (författare)
- Broad Institute
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- Lee, Ming (författare)
- University of Washington, Department of Genome Sciences
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- Liu, Ge (författare)
- Case Western Reserve University, Department of Genetics
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- Lopez-Otin, Carlos (författare)
- Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Departamento de Bioquimica y Biologia Molecular
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- Makova, Kateryna (författare)
- The Pennsylvania State University, Center for Comparative Genomics and Bioinformatics and Department of Biology
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- Man, Orna (författare)
- Weizmann Institute of Science, Department of Structural Biology
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- Mardis, Elaine (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Mauceli, Evan (författare)
- Broad Institute
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- Miner, Tracie (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Nash, illiam (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Nelson, Joanne (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Pääbo, Svante (författare)
- Max Planck Institute of Evolutionary Anthropology
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- Patterson, Nick (författare)
- Broad Institute
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- Pohl, Craig (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Pollard, Katherine (författare)
- University of California, Santa Cruz, Center for Biomolecular Science and Engineering
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- Prüfer, Kay (författare)
- Max Planck Institute for Evolutionary Anthropology
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- Puente, Xose (författare)
- Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Departamento de Bioquimica y Biologia Molecular
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- Reich, David (författare)
- Broad Institute
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- Rocchi, Mariano (författare)
- University of Bari, Department of Genetics and Microbiology
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- Rosenbloom, Kate (författare)
- University of California, Santa Cruz, Center for Biomolecular Science and Engineering
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- Ruvolo, Maryellen (författare)
- Harvard University, Department of Anthropology and of Organismic and Evolutionary Biology
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- Richter, Daniel (författare)
- Broad Institute
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- Schaffner, Stephen (författare)
- Broad Institute
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- Smit, Arian (författare)
- Institute for Systems Biology
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- Smith, Scott (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Suyama, Mikita (författare)
- EMBL
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- Taylor, James (författare)
- The Pennsylvania State University, Center for Comparative Genomics and Bioinformatics and Department of Biology
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- Torrents, David (författare)
- EMBL
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- Tuzun, Eray (författare)
- University of Washington, Department of Genome Sciences
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- Varki, Ajit (författare)
- University of California, San Diego
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- Velasco, Gloria (författare)
- Universidad de Oviedo, Instituto Universitario de Oncologia del Principado de Asturias, Departamento de Bioquimica y Biologia Molecular
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- Ventura, Mario (författare)
- University of Bari, Department of Genetics and Microbiology
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- Wallis, John (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Wendl, Michael (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Wilson, Richard (författare)
- Washington University School of Medicine, Genome Sequencing Center
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- Lander, Eric (författare)
- Broad Institute
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- Waterston, Robert (författare)
- University of Washington, Department of Genome Sciences
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2005
- 2005
- Engelska.
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 437:7055, s. 69-87
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences that have accumulated since the human and chimpanzee species diverged from our common ancestor, constituting approximately thirty-five million single-nucleotide changes, five million insertion/deletion events, and various chromosomal rearrangements. We use this catalogue to explore the magnitude and regional variation of mutational forces shaping these two genomes, and the strength of positive and negative selection acting on their genes. In particular, we find that the patterns of evolution in human and chimpanzee protein-coding genes are highly correlated and dominated by the fixation of neutral and slightly deleterious alleles. We also use the chimpanzee genome as an outgroup to investigate human population genetics and identify signatures of selective sweeps in recent human evolution.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Nyckelord
- Genetics
- Genetik
- Genetics
- Genetik
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- art (ämneskategori)
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Mikkelsen, Tarje ...
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Hillier, LaDeana
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Eichler, Evan
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Zody, Michael, 1 ...
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Jaffe, David
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Yang, Shiaw-Pyng
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Enard, Wolfgang
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Hellmann, Ines
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Lindblad-Toh, Ke ...
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Altheide, Tasha
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Archidiacono, Ni ...
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Bork, Peer
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Butler, Jonathan
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Chang, Jean
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Cheng, Ze
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Chinwalla, Asif
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de Jong, Pieter
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Delehaunty, Kimb ...
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Fronick, Catrina
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Fulton, Lucinda
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Gilad, Yoav
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Glusman, Gustavo
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Gnerre, Sante
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Graves, Tina
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Hayakawa, Toshiy ...
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Hayden, Karen
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Huang, Xiaoqiu
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Ji, Hongkai
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Kent, W.
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King, Mary-Clair ...
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Kulbokas, Edward
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Lee, Ming
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Liu, Ge
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Lopez-Otin, Carl ...
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Makova, Kateryna
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Man, Orna
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Mardis, Elaine
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Mauceli, Evan
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Miner, Tracie
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Nash, illiam
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Nelson, Joanne
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Pääbo, Svante
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Patterson, Nick
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Pohl, Craig
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Pollard, Katheri ...
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Prüfer, Kay
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Puente, Xose
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Reich, David
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Rocchi, Mariano
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Rosenbloom, Kate
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Ruvolo, Maryelle ...
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Richter, Daniel
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Schaffner, Steph ...
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Smit, Arian
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Smith, Scott
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Suyama, Mikita
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Taylor, James
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Torrents, David
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Tuzun, Eray
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Varki, Ajit
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Velasco, Gloria
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Ventura, Mario
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Wallis, John
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Wendl, Michael
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Wilson, Richard
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Lander, Eric
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Waterston, Rober ...
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