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| 2. |
- Blaauw, M., et al.
(författare)
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Bayesian testing for synchrony of events in glacial proxy archives
- 2007
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Ingår i: European Geosciences Union, 2007. ; , s. 00301-
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Often chronological uncertainties are ignored in multi-site comparisons, resulting inpotentially wrong assumptions concerning (a)synchrony of events between archives.We explore this problem in a Bayesian framework, constructing millions of plausiblewiggle-match age-models in order to quantify the chronological uncertainties withinand between proxy archives. Using these data we can now calculate the statisticalprobability that events indeed coincided. The method is applied to a high-resolution14C and OSL dated lake core from south-eastern France which largely predates theIntCal04 14C calibration curve. Depending on the applied comparison curve, eventsin this core appear synchronous or asynchronous with events in the NGRIP ice core.
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| 3. |
- Emri, M., et al.
(författare)
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Software development framework supporting multimodal tomographic imaging
- 2007
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Ingår i: 2006 IEEE Nuclear Science Symposium Conference Record. - : IEEE. - 1424405610 - 9781424405619 ; , s. 1857-1859
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Konferensbidrag (refereegranskat)abstract
- Engineers specialized in multimodal tomography regularly face a wide scale of programming tasks requiring an integrated software system to ensure cost efficiency. Accordingly, a software development framework has been worked out comprising libraries for cluster-based data acquisition, image reconstruction, management of data files and complex multimodal volumetric visualization. This framework enabled us to develop complex software for our miniPET project [1]. This software contains a graphical application integrating data acquisition, cluster monitoring, event sorting, image reconstruction, interactive image processing tools for advanced multimodal visualization. It also contains utilities to solve these tasks without graphical user interface. The components of our acquisition program can run on embedded Linux systems making new ways to develop any other types of data acquisition software that uses embedded Linux systems. A versatile development framework is developed containing specific libraries and special file formats that support multimodal tomography. This framework was successfully used to elaborate our complex miniPET software.
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| 4. |
- Feurdean, Angelica, et al.
(författare)
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Younger Dryas to mid-Holocene environmental history of the lowlands of NW Transylvania, Romania
- 2007
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Ingår i: Quaternary Research. - : Cambridge University Press (CUP). - 0033-5894 .- 1096-0287. ; 68:3, s. 364-378
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Tidskriftsartikel (refereegranskat)abstract
- Pollen, micro-charcoal and total carbon analyses on sediments from the Turbuta palaeolake, in the Transylvanian Basin of NW Romania, reveal Younger Dryas to mid-Holocene environmental changes. The chronostratigraphy relies on AMS 14C measurements on organic matter and U/Th TIMS datings of snail shells. Results indicate the presence of Pinus and Betula open woodlands with small populations of Picea, Ulmus, Alnus and Salix before 12,000 cal yr BP. A fairly abrupt replacement of Pinus and Betula by Ulmus-dominated woodlands at ca. 11,900 cal. yr BP likely represents competition effects of vegetation driven by climate warming at the onset of the Holocene. By 11,000 cal yr BP, the woodlands were increasingly diverse and dense with the expansion of Quercus, Fraxinus and Tilia, the establishment of Corylus and the decline of upland herbaceous and shrubs taxa. The marked expansion of Quercus accompanied by Tilia between 10,500 and 8000 cal yr BP could be the result of low effective moisture associated with both low elevation of the site and with regional change towards a drier climate. At 10,000 cal yr BP, Corylus spread across the region, and by 8000 cal yr BP it replaced Quercus as a dominant forest constituent, with only little representation of Picea abies. Carpinus became established around 5500 cal yr BP, but it was only a minor constituent in local woodlands until ca. 5000 cal yr BP. Results from this study also indicate that the woodlands in the lowlands of Turbuta were never closed.
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| 5. |
- Heyman, Jakob, 1979-, et al.
(författare)
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Palaeoglaciation of Bayan Har Shan, northeastern Tibetan Plateau: glacial geology indicates maximum extents limited to ice cap and ice field scales
- 2009
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Ingår i: Journal of Quaternary Science. - : John Wiley & Sons. - 0267-8179 .- 1099-1417. ; 24:7, s. 710-727
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Tidskriftsartikel (refereegranskat)abstract
- Key locations within an extensive area of the northeastern Tibetan Plateau, centred on Bayan Har Shan, have been mapped to distinguish glacial from non-glacial deposits. Prior work suggests palaeo-glaciers ranging from valley glaciers and local ice caps in the highest mountains to a regional or even plateau-scale ice sheet. New field data show that glacial deposits are abundant in high mountain areas in association with large-scale glacial landforms. In addition, glacial deposits are present in several locations outside areas with distinct glacial erosional landforms, indicating that the most extensive palaeo-glaciers had little geomorphological impact on the landscape towards their margins. The glacial geological record does indicate extensive maximum glaciation, with local ice caps covering entire elevated mountain areas. However, absence of glacial traces in intervening lower-lying plateau areas suggests that local ice caps did not merge to form a regional ice sheet on the northeastern Tibetan Plateau around Bayan Har Shan. No evidence exists for past ice sheet glaciation.
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| 6. |
- Rethi, B, et al.
(författare)
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SLAM/SLAM interactions inhibit CD40-induced production of inflammatory cytokines in monocyte-derived dendritic cells
- 2006
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Ingår i: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 107:7, s. 2821-2829
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Tidskriftsartikel (refereegranskat)abstract
- Signaling lymphocyte activation molecule (SLAM, CD150, or SLAMF1) is a self-ligand receptor on the surface of activated T- and B-lymphocytes, macrophages, and dendritic cells (DCs). Here we examine the effect of SLAM/SLAM interactions on CD40L-induced CD40 signaling pathways in human DCs. CD40L-expressing L929 cells induced DCs to produce interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and IL-12, which was strongly inhibited by coexpression of SLAM on the surface of the L929 cells. Similarly, transfection of DCs with SLAM strongly reduced CD40L-induced IL-12 production. Furthermore, the negative effect of SLAM/SLAM interactions on CD40L-induced DC activation was also detected in the presence of lipopolysaccharide (LPS). LPS-induced IL-12 secretion, however, was not inhibited by SLAM engagement. CD40L-activated DCs affected by exposure to SLAM/SLAM engagement were impaired in their ability to induce differentiation of naive T lymphocytes into interferon-γ (IFN-γ)–producing T-helper 1 (Th1) effector cells. These inhibitory effects were not the result of a general unresponsiveness of DCs to CD40L, as SLAM/SLAM interactions did not prevent CD40L-induced up-regulation of CD83, CD86, or human leukocyte antigen (HLA)–DQ on the surface of DCs. Taken together, the results indicate that SLAM/SLAM interactions inhibit CD40-induced signal transduction in monocyte-derived dendritic cells, an effect that was not detectable in earlier studies using anti-SLAM monoclonal antibodies.
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