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- Gustafsson, I.-B., et al.
(författare)
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Moderate amounts of n-3 fatty acid enriched seafood products are effective in lowering serum triglycerides and blood pressure in healthy subjects
- 1996
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Ingår i: Journal of human nutrition and dietetics (Print). - 0952-3871 .- 1365-277X. ; 9:2, s. 135-145
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Tidskriftsartikel (refereegranskat)abstract
- A double-blind cross-over study was conducted during two 3-week periods. Two series of seafood products were prepared, one containing n-3 fatty acids derived from fish oil triglyceride concentrate and one containing n-6 rich sunflower oil in identical amounts. These products were added to the subjects' ordinary diet. After a wash-out period of at least 4 weeks they switched over to the other diet. Twenty-three subjects with borderline high blood lipids participated, five women and 19 men, with a mean age of 48 ± 9 years. The inclusion of the n-3 enriched seafood products in the diet caused significant reductions of serum triglycerides (25%) and of the systolic blood pressure of 3.7%. An increase in the proportion of long-chain fatty acids in the serum phospholipids after the fish oil period was pronounced. Positive effects were seen on insulin and free fatty acid concentrations with a reduction of 37% of free fatty acids on the fish oil period and of 18.6% of serum insulin concentration. An increase of malondialdehyde concentration in plasma by 21% was seen during the fish oil period. The positive effects on the serum triglyceride and blood pressure are interesting from the viewpoint of public health with regard to the risk of the cardiovascular disease.
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- Smedman, A E, et al.
(författare)
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Pentadecanoic acid in serum as a marker for intake of milk fat : relations between intake of milk fat and metabolic risk factors.
- 1999
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Ingår i: American Journal of Clinical Nutrition. - : Elsevier BV. - 0002-9165 .- 1938-3207. ; 69:1, s. 22-9
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The fatty acid composition of the diet is known to be partially reflected by the fatty acid composition of serum lipids.OBJECTIVE: We examined whether pentadecanoic acid (15:0) in serum lipids can be used as a marker for intake of milk fat, the major dietary source of 15:0. We also investigated the relations between intake of milk fat and cardiovascular disease risk factors.DESIGN: Sixty-two 70-y-old men completed 7-d dietary records. The intake of milk products was studied in relation to the proportions of 15:0 in serum cholesterol esters and phospholipids, as well as to the clinical characteristics of these men, by using Spearman's rank correlation.RESULTS: The proportions of 15:0 in serum cholesterol esters were positively related to butter intake (r = 0.36. P = 0.004) and to the total amount of fat from milk products (r = 0.46, P < 0.0001): 15:0 in phospholipids was related to the amount of fat from milk and cream (r = 0.34, P = 0.008) and to the total amount of fat from milk products (r = 0.34, P = 0.008). Inverse associations were found between intake of milk products and body mass index, waist circumference, LDL-HDL ratio, HDL triacylglycerols, and fasting plasma glucose, whereas relations to HDL cholesterol and apolipoprotein A-I tended to be positive.CONCLUSIONS: The results suggest that 15:0 in serum can be used as a marker for intake of milk fat. The explanation for the inverse associations between the intake of milk products and certain cardiovascular risk factors is not known.
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