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Träfflista för sökning "WFRF:(Vetter I) srt2:(2015-2019)"

Sökning: WFRF:(Vetter I) > (2015-2019)

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2.
  • Abgrall, N., et al. (författare)
  • The large enriched germanium experiment for neutrinoless double beta decay (LEGEND)
  • 2017
  • Ingår i: AIP Conference Proceedings. - : Author(s). - 1551-7616 .- 0094-243X. ; 1894
  • Konferensbidrag (refereegranskat)abstract
    • The observation of neutrinoless double-beta decay (0νββ) would show that lepton number is violated, reveal that neu-trinos are Majorana particles, and provide information on neutrino mass. A discovery-capable experiment covering the inverted ordering region, with effective Majorana neutrino masses of 15 - 50 meV, will require a tonne-scale experiment with excellent energy resolution and extremely low backgrounds, at the level of ∼0.1 count /(FWHM·t·yr) in the region of the signal. The current generation 76Ge experiments GERDA and the Majorana Demonstrator, utilizing high purity Germanium detectors with an intrinsic energy resolution of 0.12%, have achieved the lowest backgrounds by over an order of magnitude in the 0νββ signal region of all 0νββ experiments. Building on this success, the LEGEND collaboration has been formed to pursue a tonne-scale 76Ge experiment. The collaboration aims to develop a phased 0νββ experimental program with discovery potential at a half-life approaching or at 1028 years, using existing resources as appropriate to expedite physics results.
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3.
  • Shepherd, L., et al. (författare)
  • Infection-related and -unrelated malignancies, HIV and the aging population
  • 2016
  • Ingår i: HIV Medicine. - : Wiley. - 1464-2662 .- 1468-1293. ; 17:8, s. 590-600
  • Tidskriftsartikel (refereegranskat)abstract
    • Objectives: HIV-positive people have increased risk of infection-related malignancies (IRMs) and infection-unrelated malignancies (IURMs). The aim of the study was to determine the impact of aging on future IRM and IURM incidence. Methods: People enrolled in EuroSIDA and followed from the latest of the first visit or 1 January 2001 until the last visit or death were included in the study. Poisson regression was used to investigate the impact of aging on the incidence of IRMs and IURMs, adjusting for demographic, clinical and laboratory confounders. Linear exponential smoothing models forecasted future incidence. Results: A total of 15 648 people contributed 95 033 person-years of follow-up, of whom 610 developed 643 malignancies [IRMs: 388 (60%); IURMs: 255 (40%)]. After adjustment, a higher IRM incidence was associated with a lower CD4 count [adjusted incidence rate ratio (aIRR) CD4 count < 200 cells/μL: 3.77; 95% confidence interval (CI) 2.59, 5.51; compared with ≥ 500 cells/μL], independent of age, while a CD4 count < 200 cells/μL was associated with IURMs in people aged < 50 years only (aIRR: 2.51; 95% CI 1.40–4.54). Smoking was associated with IURMs (aIRR: 1.75; 95% CI 1.23, 2.49) compared with never smokers in people aged ≥ 50 years only, and not with IRMs. The incidences of both IURMs and IRMs increased with older age. It was projected that the incidence of IRMs would decrease by 29% over a 5-year period from 3.1 (95% CI 1.5–5.9) per 1000 person-years in 2011, whereas the IURM incidence would increase by 44% from 4.1 (95% CI 2.2–7.2) per 1000 person-years over the same period. Conclusions: Demographic and HIV-related risk factors for IURMs (aging and smoking) and IRMs (immunodeficiency and ongoing viral replication) differ markedly and the contribution from IURMs relative to IRMs will continue to increase as a result of aging of the HIV-infected population, high smoking and lung cancer prevalence and a low prevalence of untreated HIV infection. These findings suggest the need for targeted preventive measures and evaluation of the cost−benefit of screening for IURMs in HIV-infected populations.
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5.
  • Bruce, Louise C, et al. (författare)
  • A multi-lake comparative analysis of the General Lake Model (GLM) : Stress-testing across a global observatory network
  • 2018
  • Ingår i: Environmental Modelling & Software. - : Elsevier BV. - 1364-8152 .- 1873-6726. ; 102, s. 274-291
  • Tidskriftsartikel (refereegranskat)abstract
    • The modelling community has identified challenges for the integration and assessment of lake models due to the diversity of modelling approaches and lakes. In this study, we develop and assess a one-dimensional lake model and apply it to 32 lakes from a global observatory network. The data set included lakes over broad ranges in latitude, climatic zones, size, residence time, mixing regime and trophic level. Model performance was evaluated using several error assessment metrics, and a sensitivity analysis was conducted for nine parameters that governed the surface heat exchange and mixing efficiency. There was low correlation between input data uncertainty and model performance and predictions of temperature were less sensitive to model parameters than prediction of thermocline depth and Schmidt stability. The study provides guidance to where the general model approach and associated assumptions work, and cases where adjustments to model parameterisations and/or structure are required.
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6.
  • Drezner, J. A., et al. (författare)
  • International criteria for electrocardiographic interpretation in athletes: Consensus statement
  • 2017
  • Ingår i: Br J Sports Med. - : BMJ. - 0306-3674. ; 51:9, s. 704-731
  • Tidskriftsartikel (refereegranskat)abstract
    • Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete. A critical need exists for physician education in modern ECG interpretation that distinguishes normal physiological adaptations in athletes from distinctly abnormal findings suggestive of underlying pathology. Since the original 2010 European Society of Cardiology recommendations for ECG interpretation in athletes, ECG standards have evolved quickly, advanced by a growing body of scientific data and investigations that both examine proposed criteria sets and establish new evidence to guide refinements. On 26-27 February 2015, an international group of experts in sports cardiology, inherited cardiac disease, and sports medicine convened in Seattle, Washington (USA), to update contemporary standards for ECG interpretation in athletes. The objective of the meeting was to define and revise ECG interpretation standards based on new and emerging research and to develop a clear guide to the proper evaluation of ECG abnormalities in athletes. This statement represents an international consensus for ECG interpretation in athletes and provides expert opinion-based recommendations linking specific ECG abnormalities and the secondary evaluation for conditions associated with SCD.
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7.
  • Markidis, Stefano, et al. (författare)
  • NVIDIA tensor core programmability, performance & precision
  • 2018
  • Ingår i: Proceedings - 2018 IEEE 32nd International Parallel and Distributed Processing Symposium Workshops, IPDPSW 2018. - : Institute of Electrical and Electronics Engineers (IEEE). - 9781538655559 ; , s. 522-531
  • Konferensbidrag (refereegranskat)abstract
    • The NVIDIA Volta GPU microarchitecture introduces a specialized unit, called Tensor Core that performs one matrix-multiply-and-accumulate on 4x4 matrices per clock cycle. The NVIDIA Tesla V100 accelerator, featuring the Volta microarchitecture, provides 640 Tensor Cores with a theoretical peak performance of 125 Tflops/s in mixed precision. In this paper, we investigate current approaches to program NVIDIA Tensor Cores, their performances and the precision loss due to computation in mixed precision. Currently, NVIDIA provides three different ways of programming matrix-multiply-and-accumulate on Tensor Cores: the CUDA Warp Matrix Multiply Accumulate (WMMA) API, CUTLASS, a templated library based on WMMA, and cuBLAS GEMM. After experimenting with different approaches, we found that NVIDIA Tensor Cores can deliver up to 83 Tflops/s in mixed precision on a Tesla V100 GPU, seven and three times the performance in single and half precision respectively. A WMMA implementation of batched GEMM reaches a performance of 4 Tflops/s. While precision loss due to matrix multiplication with half precision input might be critical in many HPC applications, it can be considerably reduced at the cost of increased computation. Our results indicate that HPC applications using matrix multiplications can strongly benefit from using of NVIDIA Tensor Cores.
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8.
  • Peng, I. B., et al. (författare)
  • Characterizing the performance benefit of hybrid memory system for HPC applications
  • 2018
  • Ingår i: Parallel Computing. - : Elsevier. - 0167-8191 .- 1872-7336. ; 76, s. 57-69
  • Tidskriftsartikel (refereegranskat)abstract
    • Heterogenous memory systems that consist of multiple memory technologies are becoming common in high-performance computing environments. Modern processors and accelerators, such as the Intel Knights Landing (KNL) CPU and NVIDIA Volta GPU, feature small-size high-bandwidth memory near the compute cores and large-size normal-bandwidth memory that is connected off-chip. Theoretically, HBM can provide about four times higher bandwidth than conventional DRAM. However, many factors impact the actual performance improvement that an application can achieve on such system. In this paper, we focus on the Intel KNL system and identify the most important factors on the application performance, including the application memory access pattern, the problem size, the threading level and the actual memory configuration. We use a set of representative applications from both scientific and data-analytics domains. Our results show that applications with regular memory access benefit from MCDRAM, achieving up to three times performance when compared to the performance obtained using only DRAM. On the contrary, applications with irregular memory access pattern are latency-bound and may suffer from performance degradation when using only MCDRAM. Also, we provide memory-centric analysis of four applications, identify their major data objects, correlate their characteristics to the performance improvement on the testbed.
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10.
  • Sharma, S., et al. (författare)
  • International Recommendations for Electrocardiographic Interpretation in Athletes
  • 2017
  • Ingår i: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 69:8, s. 1057-1075
  • Tidskriftsartikel (refereegranskat)abstract
    • Sudden cardiac death (SCD) is the leading cause of mortality in athletes during sport. A variety of mostly hereditary, structural, or electrical cardiac disorders are associated with SCD in young athletes, the majority of which can be identified or suggested by abnormalities on a resting 12-lead electrocardiogram (ECG). Whether used for diagnostic or screening purposes, physicians responsible for the cardiovascular care of athletes should be knowledgeable and competent in ECG interpretation in athletes. However, in most countries a shortage of physician expertise limits wider application of the ECG in the care of the athlete. A critical need exists for physician education in modern ECG interpretation that distinguishes normal physiological adaptations in athletes from distinctly abnormal findings suggestive of underlying pathology. Since the original 2010 European Society of Cardiology recommendations for ECG interpretation in athletes, ECG standards have evolved quickly over the last decade; pushed by a growing body of scientific data that both tests proposed criteria sets and establishes new evidence to guide refinements. On February 26-27, 2015, an international group of experts in sports cardiology, inherited cardiac disease, and sports medicine convened in Seattle, Washington, to update contemporary standards for ECG interpretation in athletes. The objective of the meeting was to define and revise ECG interpretation standards based on new and emerging research and to develop a clear guide to the proper evaluation of ECG abnormalities in athletes. This statement represents an international consensus for ECG interpretation in athletes and provides expert opinion-based recommendations linking specific ECG abnormalities and the secondary evaluation for conditions associated with SCD. (C) 2017 The Authors. Published by Elsevier Inc. on behalf of American College of Cardiology Foundation. All rights reserved.
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