Sökning: WFRF:(Vidal Pineiro Didac)
> (2019) >
Maintained Frontal ...
Maintained Frontal Activity Underlies High Memory Function Over 8 Years in Aging
-
Vidal-Pineiro, Didac (författare)
-
Sneve, Markus H. (författare)
-
- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI),Fysiologi
-
visa fler...
-
Mowinckel, Athanasia M. (författare)
-
Sederevicius, Donatas (författare)
-
Walhovd, Kristine B. (författare)
-
Fjell, Anders M. (författare)
-
visa färre...
-
(creator_code:org_t)
- 2018-08-23
- 2019
- Engelska.
-
Ingår i: Cerebral Cortex. - : OXFORD UNIV PRESS INC. - 1047-3211 .- 1460-2199. ; 29:7, s. 3111-3123
- Relaterad länk:
-
https://academic.oup...
-
visa fler...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Aging is characterized by substantial average decline in memory performance. Yet contradictory explanations have been given for how the brains of high-performing older adults work: either by engagement of compensatory processes such as recruitment of additional networks or by maintaining young adults' patterns of activity. Distinguishing these components requires large experimental samples and longitudinal follow-up. Here, we investigate which features are key to high memory in aging, directly testing these hypotheses by studying a large sample of adult participants (n > 300) with fMRI during an episodic memory experiment where item-context relationships were implicitly encoded. The analyses revealed that low levels of activity in frontal networks-known to be involved in memory encoding-were associated with low memory performance in the older adults only. Importantly, older participants with low memory performance and low frontal activity exhibited a strong longitudinal memory decline in an independent verbal episodic memory task spanning 8 years back (n = 52). These participants were also characterized by lower hippocampal volumes and steeper rates of cortical atrophy. Altogether, maintenance of frontal brain function during encoding seems to be a primary characteristic of preservation of memory function in aging, likely reflecting intact ability to integrate information.
Ämnesord
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
Nyckelord
- aging
- brain maintenance
- encoding
- episodic memory
- fMRI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas