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Chronic hepatitis C...
Chronic hepatitis C virus infection triggers spontaneous differential expression of biosignatures associated with T cell exhaustion and apoptosis signaling in peripheral blood mononucleocytes
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- Barathan, Muttiah (författare)
- University of Malaya, Malaysia
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- Gopal, Kaliappan (författare)
- University of Malaya, Malaysia
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- Mohamed, Rosmawati (författare)
- University of Malaya, Malaysia
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- Ellegård, Rada (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Saeidi, Alireza (författare)
- University of Malaya, Malaysia
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- Vadivelu, Jamuna (författare)
- University of Malaya, Malaysia
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- Ansari, Abdul W. (författare)
- University of Malaya, Malaysia
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- Rothan, Hussin A. (författare)
- University of Malaya, Malaysia
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- Ram, M. Ravishankar (författare)
- University of Malaya, Malaysia
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- Zandi, Keivan (författare)
- University of Malaya, Malaysia
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- Chang, Li Y. (författare)
- University of Malaya, Malaysia
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- Vignesh, Ramachandran (författare)
- YRG Centre AIDS Research and Educ, India
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- Che, Karlhans F. (författare)
- Karolinska Institutet
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- Kamarulzaman, Adeeba (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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- Velu, Vijayakumar (författare)
- Emory Vaccine Centre, GA USA
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- Larsson, Marie (författare)
- Linköpings universitet,Avdelningen för mikrobiologi och molekylär medicin,Hälsouniversitetet
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- Kamarul, Tunku (författare)
- University of Malaya, Malaysia
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- Shankar, Esaki M. (författare)
- University of Malaya, Malaysia; University of Malaya, Malaysia
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(creator_code:org_t)
- 2015-01-11
- 2015
- Engelska.
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Ingår i: Apoptosis (London). - : Springer Verlag (Germany). - 1360-8185 .- 1573-675X. ; 20:4, s. 466-480
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Persistent hepatitis C virus (HCV) infection appears to trigger the onset of immune exhaustion to potentially assist viral persistence in the host, eventually leading to hepatocellular carcinoma. The role of HCV on the spontaneous expression of markers suggestive of immune exhaustion and spontaneous apoptosis in immune cells of chronic HCV (CHC) disease largely remain elusive. We investigated the peripheral blood mononuclear cells of CHC patients to determine the spontaneous recruitment of cellular reactive oxygen species (cROS), immunoregulatory and exhaustion markers relative to healthy controls. Using a commercial QuantiGenePlex(A (R)) 2.0 assay, we determined the spontaneous expression profile of 80 different pro- and anti-apoptotic genes in persistent HCV disease. Onset of spontaneous apoptosis significantly correlated with the up-regulation of cROS, indoleamine 2,3-dioxygenase (IDO), cyclooxygenase-2/prostaglandin H synthase (COX-2/PGHS), Foxp3, Dtx1, Blimp1, Lag3 and Cd160. Besides, spontaneous differential surface protein expression suggestive of T cell inhibition viz., TRAIL, TIM-3, PD-1 and BTLA on CD4+ and CD8+ T cells, and CTLA-4 on CD4+ T cells was also evident. Increased up-regulation of Tnf, Tp73, Casp14, Tnfrsf11b, Bik and Birc8 was observed, whereas FasLG, Fas, Ripk2, Casp3, Dapk1, Tnfrsf21, and Cflar were moderately up-regulated in HCV-infected subjects. Our observation suggests the spontaneous onset of apoptosis signaling and T cell exhaustion in chronic HCV disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Nyckelord
- Apoptosis; Caspase; Hepatitis C; Spontaneous immune exhaustion; TRAIL
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Barathan, Muttia ...
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Gopal, Kaliappan
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Mohamed, Rosmawa ...
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Ellegård, Rada
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Saeidi, Alireza
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Vadivelu, Jamuna
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Ansari, Abdul W.
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Rothan, Hussin A ...
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Ram, M. Ravishan ...
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Zandi, Keivan
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Chang, Li Y.
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Vignesh, Ramacha ...
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Che, Karlhans F.
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Kamarulzaman, Ad ...
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Velu, Vijayakuma ...
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Larsson, Marie
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Kamarul, Tunku
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Shankar, Esaki M ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
- Artiklar i publikationen
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Apoptosis (Londo ...
- Av lärosätet
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Linköpings universitet
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Karolinska Institutet