Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180): A postnatal follow-up study in rats

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Viluksela Matti) > (2020-2021) > Endocrine, metaboli...

1 av 1
Föregående post
Nästa post
Till träfflistan

Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180) : A postnatal follow-up study in rats

Alarcon, Sonia (författare): Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden

Esteban, Javier (författare): Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain

Roos, Robert (författare): Karolinska Inst, Inst Environm Med, Stockholm, Sweden.;Grand Duchy Luxembourg, Lab & Mine Inspect, Minist Work, Luxembourg, Luxembourg

visa fler...

Heikkinen, Paivi (författare): Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland

Sanchez-Perez, Ismael (författare): Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain

Adamsson, Annika (författare): Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland,Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland,Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands

Toppari, Jorma (författare): Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Res Ctr Integrat Physiol & Pharmac, FI-20520 Turku, Finland.;Univ Turku, Turku Univ Hosp, Inst Biomed, Dept Paediat,Ctr Populat Hlth Res, FI-20520 Turku, Finland

Koskela, Antti (författare): Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland

Finnila, Mikko A. J. (författare): Univ Oulu, Fac Med, Res Unit Med Imaging Phys & Technol, Oulu, Finland

Tuukkanen, Juha (författare): Univ Oulu, Inst Canc Res & Translat Med, Dept Anat & Cell Biol, Oulu, Finland

Herlin, Maria (författare): Karolinska Inst, Inst Environm Med, Stockholm, Sweden

Hamscher, Gerd (författare): Justus Liebig Univ, Inst Food Chem & Food Biotechnol, D-35392 Giessen, Germany

Leslie, Heather A. (författare): Vrije Univ Amsterdam, Dept Environm & Hlth, De Boelelaan 1108, NL-1081 HZ Amsterdam, Netherlands

Korkalainen, Merja (författare): Finnish Inst Hlth & Welf THL, Environm Hlth Unit, POB 95, FI-70701 Kuopio, Finland

Halldin, Krister (författare): Uppsala universitet,Institutionen för kemi - BMC,Karolinska Inst, Inst Environm Med, Stockholm, Sweden

Schrenk, Dieter (författare): Univ Kaiserslautern, Food Chem & Toxicol, D-67663 Kaiserslautern, Germany

Hakansson, Helen (författare): Karolinska Institutet,Karolinska Inst, Inst Environm Med, Stockholm, Sweden

Viluksela, Matti (författare): Univ Eastern Finland, Sch Pharm Toxicol, Dept Environm & Biol Sci, Kuopio, Finland.;Uppsala Univ, BMC, Off Med & Pharm, SE-75123 Uppsala, Sweden

visa färre...

Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain;Karolinska Inst, Inst Environm Med, Stockholm, Sweden Univ Miguel Hernandez Elche, Inst Bioingn, Elche, Alicante, Spain (creator_code:org_t)

Elsevier, 2021
2021
Engelska.
Ingår i: Reproductive Toxicology. - : Elsevier. - 0890-6238 .- 1873-1708. ; 102, s. 109-127

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

PCB 180 is a persistent and abundant non-dioxin-like PCB (NDL-PCB). We determined the developmental toxicity profile of ultrapure PCB 180 in developing offspring following in utero and lactational exposure with the focus on endocrine, metabolic and retinoid system alterations. Pregnant rats were given total doses of 0, 10, 30, 100, 300 or 1000 mg PCB 180/kg bw on gestational days 7-10 by oral gavage, and the offspring were sampled on postnatal days (PND) 7, 35 and 84. Decreased serum testosterone and triiodothyronine concentrations on PND 84, altered liver retinoid levels, increased liver weights and induced 7-pentoxyresorufin O-dealkylase (PROD) activity were the sensitive effects used for margin of exposure (MoE) calculations. Liver weights were increased together with induction of the metabolizing enzymes cytochrome P450 (CYP) 2B1, CYP3A1, and CYP1A1. Less sensitive effects included decreased serum estradiol and increased luteinizing hormone levels in females, decreased prostate and seminal vesicle weight and increased pituitary weight in males, increased cortical bone area and thickness of tibial diaphysis in females and decreased cortical bone mineral density in males. Developmental toxicity profiles were partly different in male and female offspring, males being more sensitive to increased liver weight, PROD induction and decreased thyroxine concentrations. MoE assessment indicated that the 95th percentile of current maternal PCB 180 concentrations do not exceed the estimated tolerable human lipid-based PCB 180 concentration. Although PCB 180 is much less potent than dioxin-like compounds, it shares several toxicological targets suggesting a potential for interactions.

Hitta via bibliotek

Reproductive Toxicology (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

1 av 1
Föregående post
Nästa post
Till träfflistan

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Farmakologi och ...

Artiklar i publikationen: Reproductive Tox ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Endocrine, metabolic and apical effects of in utero and lactational exposure to non-dioxin-like 2,2 ',3,4,4 ',5,5 '-heptachlorobiphenyl (PCB 180) : A postnatal follow-up study in rats

Ämnesord

Nyckelord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub