| 1. |
- Ruilope, LM, et al.
(författare)
-
Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
-
Ingår i: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
-
Tidskriftsartikel (refereegranskat)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
|
|
| 2. |
- Fuselier, S. A., et al.
(författare)
-
Large-scale characteristics of reconnection diffusion regions and associated magnetopause crossings observed by MMS
- 2017
-
Ingår i: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 122:5, s. 5466-5486
-
Tidskriftsartikel (refereegranskat)abstract
- The Magnetospheric Multiscale (MMS) mission was designed to make observations in the very small electron diffusion region (EDR), where magnetic reconnection takes place. From a data set of over 4500 magnetopause crossings obtained in the first phase of the mission, MMS had encounters near or within 12 EDRs. These 12 events and associated magnetopause crossings are considered as a group to determine if they span the widest possible range of external and internal conditions (i.e., in the solar wind and magnetosphere). In addition, observations from MMS are used to determine if there are multiple X-lines present and also to provide information on X-line location relative to the spacecraft. These 12 events represent nearly the widest possible range of conditions at the dayside magnetopause. They occur over a wide range of local times and magnetic shear angles between the magnetosheath and magnetospheric magnetic fields. Most show evidence for multiple reconnection sites.
|
|
| 3. |
- Lee, Justin H., et al.
(författare)
-
MMS Measurements and Modeling of Peculiar Electromagnetic Ion Cyclotron Waves
- 2019
-
Ingår i: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007.
-
Tidskriftsartikel (refereegranskat)abstract
- Orbiting Earth's dayside outer magnetosphere on 29 September 2015, the Magnetospheric Multiscale (MMS) satellites measured plasma composition, simultaneous electromagnetic ion cyclotron waves, and intermittent fast plasma flows consistent with ultralow frequency waves or convection. Such flows can accelerate typically unobservable low-energy plasma into a measurable energy range of spacecraft plasma instrumentation. We exploit the flow occurrence to ensure measurement of cold ion species alongside the hot particles-consisting of ionospheric heavy ions and solar wind He++-during a subinterval of wave emissions with spectral properties previously described as peculiar. Through application of the composition and multisatellite wave vector data to linear theory, we demonstrate the emissions are in fact consistent with theory, growing naturally in the He++ band with sufficient free energy.
|
|
| 4. |
- Denton, R. E., et al.
(författare)
-
Determining L-M-N Current Sheet Coordinates at the Magnetopause From Magnetospheric Multiscale Data
- 2018
-
Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 123:3, s. 2274-2295
-
Tidskriftsartikel (refereegranskat)abstract
- We discuss methods to determine L-M-N coordinate systems for current sheet crossings observed by the Magnetospheric Multiscale (MMS) spacecraft mission during ongoing reconnection, where e(L) is the direction of the reconnecting component of the magnetic field, B, and e(N) is normal to the magnetopause. We present and test a new hybrid method, with e(L) estimated as the maximum variance direction of B (MVAB) and e(N) as the direction of maximum directional derivative of B, and then adjust these directions to be perpendicular. In the best case, only small adjustment is needed. Results from this method, applied to an MMS crossing of the dayside magnetopause at 1305:45UT on 16 October 2015, are discussed and compared with those from other methods for which e(N) is obtained by other means. Each of the other evaluations can be combined with e(L) from MVAB in a generalized hybrid approach to provide an L-M-N system. The quality of the results is judged by eigenvalue ratios, constancy of directions using different data segments and methods, and expected sign and magnitude of the normal component of B. For this event, the hybrid method appears to produce e(N) accurate to within less than 10 degrees. We discuss variance analysis using the electric current density, J, or the J x B force, which yield promising results, and minimum Faraday residue analysis and MVAB alone, which can be useful for other events. We also briefly discuss results from our hybrid method and MVAB alone for a few other MMS reconnection events. Plain Language Summary We discuss methods for determining coordinate systems in order to study magnetic reconnection events at the magnetopause, the boundary between the ionized gas in the region of space dominated by the Earth's magnetic field and the ionized gas coming from the solar wind. We introduce a new method that combines results from multiple methods in order to determine the three coordinate directions in space. We demonstrate this method by applying it to an event observed by the Magnetospheric Multiscale spacecraft on 16 October 2015 and at other times.
|
|
| 5. |
- Fuselier, S. A., et al.
(författare)
-
High-density O+ in Earth's outer magnetosphere and its effect on dayside magnetopause magnetic reconnection
- 2019
-
Ingår i: Journal of Geophysical Research - Space Physics. - : AMER GEOPHYSICAL UNION. - 2169-9380 .- 2169-9402. ; 124:12, s. 10257-10269
-
Tidskriftsartikel (refereegranskat)abstract
- The warm plasma cloak is a source of magnetospheric plasma that contain significant O+. When the O+ density in the magnetosphere near the magnetopause is >0.2 cm(-3) and the H+ density is <1.5 cm(-3), then O+ dominates the magnetospheric ion mass density by more than a factor of 2. A survey is conducted of such O+-rich warm plasma cloak intervals and their effect on reconnection at the Earth's magnetopause. The survey uses data from the Magnetospheric Multiscale mission (MMS) and the results are compared and combined with a previous survey of the warm plasma cloak. Overall, the warm plasma cloak and the O+-rich warm plasma cloak reduce the magnetopause reconnection rate by >20% due to mass-loading only about 2% to 4% of the time. However, during geomagnetic storms, O+ dominates the mass density of the warm plasma cloak and these mass densities are very high. Therefore, a separate study is conducted to determine the effect of the warm plasma cloak on magnetopause reconnection during geomagnetically disturbed times. This study shows that the warm plasma cloak reduces the reconnection rate significantly about 25% of the time during disturbed conditions.
|
|
| 6. |
- Fuselier, S. A., et al.
(författare)
-
Mass Loading the Earth's Dayside Magnetopause Boundary Layer and Its Effect on Magnetic Reconnection
- 2019
-
Ingår i: Geophysical Research Letters. - : AMER GEOPHYSICAL UNION. - 0094-8276 .- 1944-8007. ; 46:12, s. 6204-6213
-
Tidskriftsartikel (refereegranskat)abstract
- When the interplanetary magnetic field is northward for a period of time, O+ from the high-latitude ionosphere escapes along reconnected magnetic field lines into the dayside magnetopause boundary layer. Dual-lobe reconnection closes these field lines, which traps O+ and mass loads the boundary layer. This O+ is an additional source of magnetospheric plasma that interacts with magnetosheath plasma through magnetic reconnection. This mass loading and interaction is illustrated through analysis of a magnetopause crossing by the Magnetospheric Multiscale spacecraft. While in the O+-rich boundary layer, the interplanetary magnetic field turns southward. As the Magnetospheric Multiscale spacecraft cross the high-shear magnetopause, reconnection signatures are observed. While the reconnection rate is likely reduced by the mass loading, reconnection is not suppressed at the magnetopause. The high-latitude dayside ionosphere is therefore a source of magnetospheric ions that contributes often to transient reduction in the reconnection rate at the dayside magnetopause.
|
|
| 7. |
- Vines, S. K., et al.
(författare)
-
Magnetospheric Ion Evolution Across the Low-Latitude Boundary Layer Separatrix
- 2017
-
Ingår i: Journal of Geophysical Research - Space Physics. - : Blackwell Publishing. - 2169-9380 .- 2169-9402. ; 122:10, s. 10247-10262
-
Tidskriftsartikel (refereegranskat)abstract
- On 20 September 2015, the Magnetospheric Multiscale (MMS) spacecraft crossed the dusk magnetopause after a compression of the magnetosphere. Enhanced densities and fluxes of both colder (≤10 eV) and hotter (>1 keV) magnetospheric and magnetosheath heavy ion species were observed reaching the magnetopause. The evolution of the velocity distributions for H+, He+, and O+ measured by the Hot Plasma Composition Analyzer on MMS during this magnetopause crossing is presented. In particular, this study focuses on the changes in the species' distribution functions as MMS passes from the magnetosphere through the electron edge of the low-latitude boundary layer (LLBL) separatrix and then into the LLBL. Two types of processes are suggested to play a role in the heating of colder magnetospheric ions across the LLBL separatrix in the region between the separatrix and the electron and ion edges of the LLBL. One mechanism leads to the formation and enhancement of ring distributions in this layer of the LLBL as the magnetospheric ions propagate across the separatrix. A second mechanism leading first to perpendicular heating and then to parallel heating of colder protons may arise from a possible two-stream instability as the magnetospheric ions first encounter the warmer magnetosheath electrons in the electron layer and then the warmer magnetosheath ions between the electron and ion edges of the LLBL separatrix. Perpendicular heating of He+ and O+ is seen more so in the main reconnection exhaust, due to nonadiabatic behavior of these ions as they are accelerated up to the bulk flow speed.
|
|
| 8. |
- Azarov, Alexander, et al.
(författare)
-
Defect annealing kinetics in ZnO implanted with Zn substituting elements : Zn interstitials and Li redistribution
- 2019
-
Ingår i: Journal of Applied Physics. - : AMER INST PHYSICS. - 0021-8979 .- 1089-7550. ; 125:7
-
Tidskriftsartikel (refereegranskat)abstract
- It is known that the behavior of residual Li in ion implanted ZnO depends on the preferential localization of the implants, in particular, forming characteristic Li depleted or Li pile-up regions for Zn or O sublattice occupation of the implants due to the corresponding excess generation of Zn and O interstitials in accordance with the so-called "+1 model." However, the present study reveals that conditions for the radiation damage annealing introduce additional complexity into the interpretation of the Li redistribution trends. Specifically, four implants residing predominantly in the Zn-sublattice, but exhibiting different lattice recovery routes, were considered. Analyzing Li redistribution trends in these samples, it is clearly shown that Li behavior depends on the defect annealing kinetics which is a strong function of the implanted fluence and ion species. Thus, Li depleted and Li pile-up regions (or even combinations of the two) were observed and correlated with the defect evolution in the samples. It is discussed how the observed Li redistribution trends can be used for better understanding a thermal evolution of point defects in ZnO and, in particular, energetics and migration properties of Zn interstitials.
|
|
| 9. |
- Bathen, M. E., et al.
(författare)
-
Anisotropic and plane-selective migration of the carbon vacancy in SiC : Theory and experiment
- 2019
-
Ingår i: Physical Review B. - : American Physical Society. - 2469-9950 .- 2469-9969. ; 100:1
-
Tidskriftsartikel (refereegranskat)abstract
- We investigate the migration mechanism of the carbon vacancy (VC) in silicon carbide (SiC) using a combination of theoretical and experimental methodologies. The VC, commonly present even in state-of-the-art epitaxial SiC material, is known to be a carrier lifetime killer and therefore strongly detrimental to device performance. The desire for VC removal has prompted extensive investigations involving its stability and reactivity. Despite suggestions from theory that VC migrates exclusively on the C sublattice via vacancy-atom exchange, experimental support for such a picture is still unavailable. Moreover, the existence of two inequivalent locations for the vacancy in 4H-SiC [hexagonal, VC(h), and pseudocubic, VC(k)] and their consequences for VC migration have not been considered so far. The first part of the paper presents a theoretical study of VC migration in 3C- and 4H-SiC. We employ a combination of nudged elastic band (NEB) and dimer methods to identify the migration mechanisms, transition state geometries, and respective energy barriers for VC migration. In 3C-SiC, VC is found to migrate with an activation energy of EA=4.0 eV. In 4H-SiC, on the other hand, we anticipate that VC migration is both anisotropic and basal-plane selective. The consequence of these effects is a slower diffusivity along the axial direction, with a predicted activation energy of EA=4.2 eV, and a striking preference for basal migration within the h plane with a barrier of EA=3.7 eV, to the detriment of the k-basal plane. Both effects are rationalized in terms of coordination and bond angle changes near the transition state. In the second part, we provide experimental data that corroborates the above theoretical picture. Anisotropic migration of VC in 4H-SiC is demonstrated by deep level transient spectroscopy (DLTS) depth profiling of the Z1/2 electron trap in annealed samples that were subject to ion implantation. Activation energies of EA=(4.4±0.3) eV and EA=(3.6±0.3) eV were found for VC migration along the c and a directions, respectively, in excellent agreement with the analogous theoretical values. The corresponding prefactors of D0=0.54cm2/s and 0.017cm2/s are in line with a simple jump process, as expected for a primary vacancy point defect.
|
|
| 10. |
- Khranovskyy, Volodymyr, et al.
(författare)
-
Complementary study of the photoluminescence and electrical properties of ZnO films grown on 4H-SiC substrates
- 2017
-
Ingår i: Journal of Luminescence. - : ELSEVIER SCIENCE BV. - 0022-2313 .- 1872-7883. ; 181, s. 374-381
-
Tidskriftsartikel (refereegranskat)abstract
- We have studied the photoluminescence and electrical properties of ZnO films grown epitaxially by atmospheric pressure MOCVD on 4H-SiC substrates. The dominating DA line on the low temperature PL spectrum is attributed to the emission of an exciton bound to the neutral donor. The intensity of this line correlates with the electrical properties of the films: the decrease of DA intensity occurs simultaneously with the increase of the carriers mobility. This we explain as donor activation providing free electrons to the conduction band. Based on the comparison of the calculated value of donor binding energy, the literature data and complementary SIMS analysis a suggested donor impurity is aluminum (Al). The exciton localization energy is 16.3 meV, and agrees well with localization energy of 15.3 meV for Al impurity reported by other authors (e.g. Ref. [33]). The thermal activation energy E-D=22 meV, determined from the Hall data and is in agreement with the optical activation energy 20 meV, which is derived from the temperature-dependent PL study. The calculated value of the donor binding energy of 54.3 eV is in agreement with the ionization energy of 53 meV mentioned in earlier reports for Al in ZnO films. Our results prove that the commonly observed line at similar to 3.3599 eV on low temperature PL spectra of ZnO is a neutral donor bound exciton emission due to the Al impurity. (C) 2016 Elsevier B.V. All rights reserved.
|
|
