| 1. |
- Mitchell, Jonathan S., et al.
(författare)
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Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- 2016
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Tidskriftsartikel (refereegranskat)abstract
- Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
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| 2. |
- Novakovic, Maja, et al.
(författare)
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Regulated Emissions and Detailed Particle Characterisation for Diesel and RME Biodiesel Fuel Combustion with Varying EGR in a Heavy-Duty Engine
- 2019
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Ingår i: SAE Technical Paper Series. - 400 Commonwealth Drive, Warrendale, PA, United States : SAE International. - 0148-7191. ; 2019:December
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Tidskriftsartikel (refereegranskat)abstract
- This study investigates particulate matter (PM) and regulated emissions from renewable rapeseed oil methyl ester (RME) biodiesel in pure and blended forms and contrasts that to conventional diesel fuel. Environmental and health concerns are the major motivation for combustion engines research, especially finding sustainable alternatives to fossil fuels and reducing diesel PM emissions. Fatty acid methyl esters (FAME), including RME, are renewable fuels commonly used from low level blends with diesel to full substitution. They strongly reduce the net carbon dioxide emissions. It is largely unknown how the emissions and characteristics of PM get altered by the combined effect of adding biodiesel to diesel and implementing modern engine concepts that reduce nitrogen oxides (NOx) emissions by exhaust gas recirculation (EGR). Therefore, the exhaust from a single-cylinder Scania D13 heavy-duty (HD) diesel engine fuelled with petroleum-based MK1 diesel, RME, and a 20% RME blend (B20), was sampled while the inlet oxygen concentration was stepped from ambient to very low by varying EGR. Regulated gaseous emissions, mass of total black carbon (BC) and organic aerosol (OA), particle size distributions and the soot nanostructure by means of transmission electron microscopy (TEM), were studied. For all EGR levels, RME showed reduced BC emissions (factor 2 for low and 3-4 for higher EGR) and total particulate number count (TPNC) compared with diesel and B20. B20 was closer to diesel than RME in emission levels. RME opens a significant possibility to utilise higher levels of EGR and stay in the region of low NOx, while not producing more soot than with diesel and B20. Adding EGR to 15% inlet O2 did not affect the nanostructure of PM. A difference between the fuels was noticeable: branched agglomerates of diesel and RME were composed of many primary particles, whereas those of B20 were more often “melted” together (necking).
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| 3. |
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| 4. |
- Spikol, Daniel, 1965-, et al.
(författare)
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Current and Future Multimodal Learning Analytics Data Challenges
- 2017
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Ingår i: Seventh International Learning Analytics & Knowledge Conference (LAK'17). - New York, NY, USA : ACM Digital Library. ; , s. 518-519
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Konferensbidrag (refereegranskat)abstract
- Multimodal Learning Analytics (MMLA) captures, integrates and analyzes learning traces from different sources in order to obtain a more holistic understanding of the learning process, wherever it happens. MMLA leverages the increasingly widespread availability of diverse sensors, high-frequency data collection technologies and sophisticated machine learning and artificial intelligence techniques. The aim of this workshop is twofold: first, to expose participants to, and develop, different multimodal datasets that reflect how MMLA can bring new insights and opportunities to investigate complex learning processes and environments; second, to collaboratively identify a set of grand challenges for further MMLA research, built upon the foundations of previous workshops on the topic.
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| 5. |
- Swaminathan, Bhairavi, et al.
(författare)
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Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
- 2015
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Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 1-8
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Tidskriftsartikel (refereegranskat)abstract
- Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 (rs56219066T; odds ratio (OR)=1.25; P=9.6 × 10(-10)). This gene encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells. We find that the MM risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation. Consistent with a hypomorphic effect, we find that the MM risk allele also associates with reduced levels of immunoglobulin A (IgA) and G (IgG) in healthy subjects (P=8.6 × 10(-9) and P=6.4 × 10(-3), respectively) and, potentially, with an increased risk of bacterial meningitis (OR=1.30; P=0.0024).
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| 6. |
- Vogel, G., et al.
(författare)
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Health-related quality of life after general surgical intensive care
- 2018
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Ingår i: Acta Anaesthesiologica Scandinavica. - : Wiley-Blackwell. - 0001-5172 .- 1399-6576. ; 62:8, s. 1112-1119
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundImpaired mental and physical health are common complications after intensive care that could influence the patient's health-related quality of life (HRQoL). Earlier research has mainly focused on HRQoL in mixed surgical and medical ICU populations. This study aimed to describe and analyze factors associated with HROoL after discharge from a general surgical ICU. MethodsA prospective cohort study was conducted in a general surgical ICU in Sweden between 2005 and 2012. Adult patients (18years) with an ICU length of stay 96hours were included. HRQoL was measured at 3, 6, and 12months after discharge from the ICU using a questionnaire (SF-36). A linear mixed model was used to analyze changes over time and Wilcoxon Signed Rank Tests were used to compare the 12-months results to an age and gender matched reference population in Sweden. Linear regression analyses were performed to explore the impact on HRQoL from background variables. ResultsOf 447 patients eligible for the study, 276 patients (62%) answered SF-36 at least once at 3, 6 or 12months after ICU care and were included in the study. HRQoL improved over time but was still significantly lower at 12months compared to the reference population. Female gender, age <75years, living single, and ICU-stay of more than 14days were associated with lower HRQoL. ConclusionGeneral surgical ICU patients reports low HRQoL 1year after ICU stay. The impaired HRQoL could be a long-lasting problem with major consequences for the individual, family, and society.
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