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- Heindel, Jerrold J., et al.
(författare)
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Obesity II : Establishing causal links between chemical exposures and obesity
- 2022
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Ingår i: Biochemical Pharmacology. - : Elsevier. - 0006-2952 .- 1356-1839 .- 1873-2968. ; 199
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Forskningsöversikt (refereegranskat)abstract
- Obesity is a multifactorial disease with both genetic and environmental components. The prevailing view is that obesity results from an imbalance between energy intake and expenditure caused by overeating and insufficient exercise. We describe another environmental element that can alter the balance between energy intake and energy expenditure: obesogens. Obesogens are a subset of environmental chemicals that act as endocrine disruptors affecting metabolic endpoints. The obesogen hypothesis posits that exposure to endocrine disruptors and other chemicals can alter the development and function of the adipose tissue, liver, pancreas, gastrointestinal tract, and brain, thus changing the set point for control of metabolism. Obesogens can determine how much food is needed to maintain homeostasis and thereby increase the susceptibility to obesity. The most sensitive time for obesogen action is in utero and early childhood, in part via epigenetic programming that can be transmitted to future generations. This review explores the evidence supporting the obesogen hypothesis and highlights knowledge gaps that have prevented widespread acceptance as a contributor to the obesity pandemic. Critically, the obesogen hypothesis changes the narrative from curing obesity to preventing obesity.
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- Weckmann, Armin, et al.
(författare)
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3D deposition patterns of deuterium retention and impurities in the COMPASS divertor : a data-driven root cause analysis and prediction approach
- 2022
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Ingår i: Fusion engineering and design. - : Elsevier BV. - 0920-3796 .- 1873-7196. ; 179
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Tidskriftsartikel (refereegranskat)abstract
- Divertor tiles from the COMPASS tokamak have been examined with ion beam analysis for the determination of deuterium retention and co-deposits. A novel approach was used to draw 2D deuterium retention maps at different depths and correlated to the concentrations of other elements: boron, carbon, oxygen and metals. This approach, which employs all three spatial dimensions, revealed that the deuterium retention pattern is not toroidally symmetric at different depths while the overall deuterium pattern is toroidally symmetric. Analysis of visible-light camera records disclosed that parts of the divertor were not wetted by plasma. The radial profile of deuterium in both wetted and non-wetted ( "shadowed ") divertor regions was compared to strike point positions, angle of incidence, electron temperature T-e, parallel heat flux Q(par) and ion saturation current Isat in order to find the influence of these parameters on deuterium retention. There are certain series of consecutive shots for which correlations between deuterium retention and separate plasma parameters (T-e, I-sat, Q(par)) are high. Combining the three parameters in a linear model or a power law model enabled reconstruction of the radial deuterium retention pattern. After fitting the model to one third of the data points, the deuterium retention for shadowed tiles was reproduced at the other two thirds of the data points within 20% deviation. This study shows the need for detailed tile analysis in three dimensions, the great benefits of broad statistical analysis in solving challenges in fusion, and motivates the investigation of COMPASS tiles after dismantling.
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