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- Amatya, B, et al.
(författare)
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Responses to intradermal injections of substance P in psoriasis patients with pruritus
- 2010
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Ingår i: Skin pharmacology and physiology. - : S. Karger AG. - 1660-5535 .- 1660-5527. ; 23:3, s. 133-138
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Tidskriftsartikel (refereegranskat)abstract
- <i>Background:</i> Various mediators have been suggested for the pathogenesis of pruritus in psoriasis. <i>Methods:</i> To investigate cutaneous responses of substance P in pruritic lesional and nonlesional areas of psoriasis patients and in healthy controls, substance P, saline and histamine were injected intradermally. After each injection, pruritus, flare and wheal were recorded. <i>Results:</i> There was no statistical difference in the latency period, duration, area under the curve and maximum intensity of pruritus evoked by substance P (10<sup>–5</sup> and 10<sup>–6</sup> mol/l) between psoriasis and healthy control skin. Substance P (10<sup>–5</sup> mol/l) induced a tendency to a greater intensity of pruritus in lesional compared to nonlesional psoriatic skin (p = 0.08). Histamine produced a shorter itch latency period (p < 0.05) and a lower maximum intensity of pruritus (p = 0.05) in lesional psoriasis skin than in healthy control skin. No significant difference in flare area was observed between the psoriasis patients and healthy controls. The histamine-induced wheal was smaller in psoriasis patients than in healthy individuals (p < 0.05). <i>Conclusion:</i> Intradermally injected substance P induced pruritus, flare and wheal in psoriasis patients. However, these responses did not differ significantly from those of the healthy controls.
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