Sökning: WFRF:(Wallaschofski Henri)
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Health-related qual...
Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy : analysis of the German KIMS data and the Study of Health in Pomerania
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Moock, Joern (författare)
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Albrecht, Christin (författare)
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Friedrich, Nele (författare)
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Volzke, Henry (författare)
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Nauck, Matthias (författare)
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- Koltowska-Häggström, Maria (författare)
- Uppsala universitet,Institutionen för farmaci
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Kohlmann, Thomas (författare)
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Wallaschofski, Henri (författare)
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(creator_code:org_t)
- 2009
- 2009
- Engelska.
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Ingår i: European Journal of Endocrinology. - 0804-4643 .- 1479-683X. ; 160:1, s. 17-24
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Objective: To analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with values from general population sample. Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated. Design: HRQoL was assessed by quality of life assessment of GH deficiency in adults (QoL-AGHDA) in 651 patients retrieved from the German KIMS (Pfizer International Metabolic Database) before and after 12 months of GH replacement and in a sample drawn from a cross-sectional study in Germany (n=2734). IGF-1 was measured in KIMS patients and in the population-based study with the same assay technique. Results: in KIMS patients, mean QoL-AGHDA scores before GH replacement were 9.2 +/- 6.8 (8.7 +/- 6.8) in women (men) and in the general population sample 4.5 +/- 5.3 (4.3 +/- 5.0) in women (men). Mean differences in QoL-AGHDA scores were statistically significant for all age categories (P<0.05). The mean IGF-1 SDS of KIMS patients before GH replacement was -1.1 +/- 1.4 (-0.8 +/- 1.4) in women (men). After GH replacement, a significant increase of IGF-1 concentration and a significant decrease of QoL-AGHDA scores near to age- and gender-specific population-based values were observed. Conclusions: This Study confirms an improvement in HRQoL and an increase of IGF-1 SDS in GH-replaced adults, which approximated the values of general population. However, there was no association between IGF-1 values and HRQoL assessment as one of the important treatment outcomes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- PHARMACY
- FARMACI
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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