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- Jonasson, Jan-Erik, et al.
(författare)
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Gjutning av vägg på platta : studier av sprickrisker orsakat av temperaturförloppet vid härdningen
- 2009
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Tests casting the construction "wall on slab" have in the project been realized for three different situations. Measurements have been performed with respect to temperatures, deformations, strains and mapping of crack patterns. In addition, properties for the young concrete have been investigated to get basic data in order to estimate temperatures and risks of cracking. The construction wall on slab represents a typical case, which can be found in many real structures like walls, retaining walls, tray structures, tunnels and bridges.The project has two main questions: 1) What are the differences in restraint conditions between the three tested constructions? Is it correct to model a wall, that both has a horizontal casting joints against the slab, and a vertical casting joint against an adjacent wall, with a free wall of double length?, and 2) Does a slip in the horizontal casting joint exist, and does is reduce the restraint in the wall?The answers are that the supposed models describe the real behaviour very well. This was confirmed by the fact that both the temperatures as well as the crack risks agreed very well between the test results and the calculation results. For the walls that cracked a slip in the casting joints could be indicated, but these test results could not be quantified. In summary, the project has been successful and clearly answered questions that previously only were based on assumptions.
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- Jonasson, Jan-Erik, et al.
(författare)
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How to build crack-free durable concrete structures : concrete hardening technology including modelling of shrinkage, creep and temperature of young concrete and its influence on durability and lifetime
- 2009
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Ingår i: ISLECI 2009. - : Central South University of Forestry and Technology, China.
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Konferensbidrag (refereegranskat)abstract
- Control of thermal and shrinkage cracking in hardening concrete is of great importance to ensure desired service life and function of concrete infrastructures. Making reliable stress estimations, and thereby conclusions about cracking risks caused by temperature movements and shrinkage involves advanced modelling of material properties and structural restraint. The paper presents the main outline of a model for description of material properties needed. Special focus is given to a creep model denoted LLM (Linear Logarithmic Model), which is shown to be robust, easy to use, and capable to extrapolate short-term test into long-term effects. Applications of the presented model using the computer program ConTeSt Pro demonstrates that it can be used to decide what measures to be taken to minimize the risk of cracking during the hardening phase for concrete structures.
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- Mattsson, Niklas, 1979, et al.
(författare)
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CSF biomarkers and incipient Alzheimer disease in patients with mild cognitive impairment.
- 2009
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Ingår i: JAMA : the journal of the American Medical Association. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 302:4, s. 385-93
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Tidskriftsartikel (refereegranskat)abstract
- CONTEXT: Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. OBJECTIVE: To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (Abeta42), total tau protein (T-tau), and tau phosphorylated at position threonine 181 (P-tau) for predicting incipient AD in patients with MCI. DESIGN, SETTING, AND PARTICIPANTS: The study had 2 parts: a cross-sectional study involving patients with AD and controls to identify cut points, followed by a prospective cohort study involving patients with MCI, conducted 1990-2007. A total of 750 individuals with MCI, 529 with AD, and 304 controls were recruited by 12 centers in Europe and the United States. Individuals with MCI were followed up for at least 2 years or until symptoms had progressed to clinical dementia. MAIN OUTCOME MEASURES: Sensitivity, specificity, positive and negative likelihood ratios (LRs) of CSF Abeta42, T-tau, and P-tau for identifying incipient AD. RESULTS: During follow-up, 271 participants with MCI were diagnosed with AD and 59 with other dementias. The Abeta42 assay in particular had considerable intersite variability. Patients who developed AD had lower median Abeta42 (356; range, 96-1075 ng/L) and higher P-tau (81; range, 15-183 ng/L) and T-tau (582; range, 83-2174 ng/L) levels than MCI patients who did not develop AD during follow-up (579; range, 121-1420 ng/L for Abeta42; 53; range, 15-163 ng/L for P-tau; and 294; range, 31-2483 ng/L for T-tau, P < .001). The area under the receiver operating characteristic curve was 0.78 (95% confidence interval [CI], 0.75-0.82) for Abeta42, 0.76 (95% CI, 0.72-0.80) for P-tau, and 0.79 (95% CI, 0.76-0.83) for T-tau. Cut-offs with sensitivity set to 85% were defined in the AD and control groups and tested in the MCI group, where the combination of Abeta42/P-tau ratio and T-tau identified incipient AD with a sensitivity of 83% (95% CI, 78%-88%), specificity 72% (95% CI, 68%-76%), positive LR, 3.0 (95% CI, 2.5-3.4), and negative LR, 0.24 (95% CI, 0.21-0.28). The positive predictive value was 62% and the negative predictive value was 88%. CONCLUSIONS: This multicenter study found that CSF Abeta42, T-tau, and P-tau identify incipient AD with good accuracy, but less accurately than reported from single-center studies. Intersite assay variability highlights a need for standardization of analytical techniques and clinical procedures.
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