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- Frey, Sharon, et al.
(författare)
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Interference of antibody production to hepatitis B surface antigen in a combination hepatitis A/hepatitis B vaccine
- 1999
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Ingår i: Journal of Infectious Diseases. - : Oxford University Press (OUP). - 0022-1899 .- 1537-6613. ; 180:6, s. 2018-2022
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Tidskriftsartikel (refereegranskat)abstract
- A randomized trial comparing 3 manufacturing consistency lots of a combination hepatitis A/hepatitis B vaccine to each other and to hepatitis A vaccine and hepatitis B vaccine given separately and concurrently was done to evaluate safety, tolerability, and immunogenicity. Healthy volunteers >/=11 years of age were divided into 4 groups. Each of 3 groups received a separate consistency lot of the combination vaccine, and 1 group received separate but concurrent injections of hepatitis A and hepatitis B vaccines. Injections were given at weeks 0 and 24. The combination vaccine was generally well tolerated. The hepatitis A portion of the combination vaccine produced clinically acceptable high seropositivity rates 4 and 52 weeks after the first injection. The hepatitis B portion of the vaccine did not produce clinically acceptable seropositivity rates 4 weeks after the second injection. Lack of antibody production may be attributed, at least in part, to immunologic interference.
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- Andersson, Agneta, et al.
(författare)
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Domiciliary liquid oxygen versus concentrator treatment in chronic hypoxaemia: a cost-utility analysis
- 1998
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Ingår i: European Respiratory Journal. - 1399-3003. ; 12:6, s. 1284-1289
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Tidskriftsartikel (refereegranskat)abstract
- Whether long-term oxygen therapy (LTOT) improves quality of life in chronic hypoxaemia has been questioned. LTOT with an oxygen concentrator (C/C) and gas cylinders for ambulation is considered cumbersome compared to mobile liquid oxygen equipment (L). The hypothesis for this study was that LTOT with liquid oxygen treatment (L) improves patients' health-related quality of life, but that it is also more expensive compared to concentrator (C/C) treatment. A prospective, randomized multicentre trial comparing C/C with L for LTOT was conducted during a six-month period. Fifty-one patients (29 on L and 22 on C/C) with chronic hypoxaemia, regularly active outside the home, participated in the study initially. Costs for oxygen were obtained from the pharmacies. Patient diaries and telephone contacts with members of the healthcare sector were used to estimate costs. Health-related quality of life was measured by the Sickness Impact Profile (SIP) and the EuroQol, instruments at the start and after 6 months. The average total cost per patient for group C/C for the six-month period was US$1,310, and for group L it was US$4,950. Health-related quality of life measured by the SIP instrument showed significant differences in favour of group L in the categories/dimensions of physical function, body care, ambulation, social interaction and total SIP score. In conclusion, liquid-oxygen treatment was more expensive compared to concentrator treatment. However, treatment effects showed that liquid oxygen had a better impact on quality of life.
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- Brandt, JC, et al.
(författare)
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A Goddard High Resolution Spectrograph atlas of echelle observations of the HgMn star chi Lupi
- 1999
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Ingår i: The Astronomical Journal. - : American Astronomical Society. - 1538-3881 .- 0004-6256. ; 117:3, s. 1505-1548
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Tidskriftsartikel (refereegranskat)abstract
- Observations of the ultra-sharp-lined, chemically peculiar star chi Lupi taken by the Goddard High Resolution Spectrograph in echelle mode are presented. Thirty-six intervals of the spectral region between 1249 and 2688 Angstrom are covered with resolving powers in the range 75,000-93,000. Line identifications are provided, and the observed spectra are compared with synthetic spectra calculated using the SYNTHE program and associated line lists with changes to the line lists. The significance of these spectra for the chi Lupi Pathfinder Project and the closely related atomic physics effort is discussed in a companion paper.
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- Hoff, P, et al.
(författare)
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Single-neutron states in Sn-133
- 1996
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Ingår i: PHYSICAL REVIEW LETTERS. - : AMER INST PHYSICS. - 0031-9007. ; 77:6, s. 1020-1023
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Tidskriftsartikel (refereegranskat)abstract
- The location of several single-neutron states in Sn-133 has been identified. The P-3/2, h(9/2), and f(5/2) states were found at 853.7, 1560.9, and 2004.6 keV, respectively, by measuring gamma rays in coincidence with delayed neutrons following the decay o
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