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| 2. |
- Popat, S, et al.
(författare)
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Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.
- 2002
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Ingår i: Annals of human genetics. - 0003-4800 .- 1469-1809. ; 66:Pt 2, s. 125-37
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Tidskriftsartikel (refereegranskat)abstract
- Susceptibility to coeliac disease involves HLA and non-HLA-linked genes. The CTLA4/CD28 gene region encodes immune regulatory T-cell surface molecules and is a strong candidate as a susceptibility locus. We evaluated CTLA4/CD28 in coeliac disease by genetic linkage and association and combined our findings with published studies through a meta-analysis. 116 multiplex families were genotyped across CTLA4/CD28 using eight markers. The contribution of CTLA4/CD28 to coeliac disease was assessed by non-parametric linkage and association analyses. Seven studies were identified that had evaluated the relationship between CTLA4/CD28 and coeliac disease and a pooled analysis of data undertaken. In our study there was evidence for a relationship between variation in the CTLA4/CD28 region and coeliac disease by linkage and association analyses. However, the findings did not attain formal statistical significance (p = 0.004 and 0.039, respectively). Pooling findings with published results showed significant evidence for linkage (504 families) and association (940 families): p values, 0.0001 and 0.0014 at D2S2214, respectively, and 0.0008 and 0.0006 at D2S116, respectively. These findings suggest that variation in the CD28/CTLA4 gene region is a determinant of coeliac disease susceptibility. Dissecting the sequence variation underlying this relationship will depend on further analyses utilising denser sets of markers.
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| 3. |
- Andreyev, A. N., et al.
(författare)
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Shape-changing particle decays of Bi-185 and structure of the lightest odd-mass Bi isotopes
- 2004
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Ingår i: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 69:5, s. 054308-
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Tidskriftsartikel (refereegranskat)abstract
- Proton and alpha decay of the proton-rich nuclide Bi-185 has been restudied in more detail in the complete fusion reaction Nb-93(Mo-95, 3n)Bi-185 at the velocity filter SHIP. The observed decay pattern of Bi-185 and of the heavier odd-mass isotopes Bi-187,Bi-189,Bi-191,Bi-193 are interpreted based on potential-energy surface calculations. It is shown that the experimental systematics of the particle decays and of the excited states in these nuclei (where known) can be explained by the prolate-oblate shape co-existence at low excitation energy. The observed state in Bi-185 is proposed to be of prolate nature, which is in contrast with the previously proposed oblate interpretation.
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| 4. |
- Bailey, S, et al.
(författare)
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Acclimation of Arabidopsis thaliana to the light environment : the existence of separate low light and high light responses
- 2001
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Ingår i: Planta. - 0032-0935 .- 1432-2048. ; 213:5, s. 794-801
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Tidskriftsartikel (refereegranskat)abstract
- The capacity for photosynthetic acclimation in Arabidopsis thaliana (L.) Heynh. cv. Landsberg erecta was assessed during growth over a broad range of irradiance. Discontinuities in the response to growth irradiance were revealed for the light- and CO2-saturated rate of photosynthesis (P-max) and the ratio of chlorophyll a to chlorophyll b (Chl a/b). Three separate phases in the response of P-max and Chl a/b to growth light were evident, with increases at low and high irradiance ranges and a plateau at intermediate irradiance. By measuring all chlorophyll-containing components of the thylakoid membrane that contribute to Chl alb we reveal that distinct strategies for growth at low and high irradiance underlie the discontinuous response. These strategies include, in addition to changes in the major light-harvesting complexes of photosystem II (LHCII) , large shifts in the amounts of both reaction centres as well as significant changes in the levels of minor LHCII and LHCI components.
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