| 1. |
- Birney, Ewan, et al.
(författare)
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Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
- 2007
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 447:7146, s. 799-816
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Tidskriftsartikel (refereegranskat)abstract
- We report the generation and analysis of functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project. These data have been further integrated and augmented by a number of evolutionary and computational analyses. Together, our results advance the collective knowledge about human genome function in several major areas. First, our studies provide convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts, including non-protein-coding transcripts, and those that extensively overlap one another. Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. Third, a more sophisticated view of chromatin structure has emerged, including its inter-relationship with DNA replication and transcriptional regulation. Finally, integration of these new sources of information, in particular with respect to mammalian evolution based on inter- and intra-species sequence comparisons, has yielded new mechanistic and evolutionary insights concerning the functional landscape of the human genome. Together, these studies are defining a path for pursuit of a more comprehensive characterization of human genome function.
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| 2. |
- Chen, Chuan-Ren, et al.
(författare)
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Color Sextet Scalars at the CERN Large Hadron Collider
- 2009
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Ingår i: Physical Review D. - 1550-7998 .- 1550-2368. ; 79:5, s. 054002-
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Tidskriftsartikel (refereegranskat)abstract
- Taking a phenomenological approach, we study a color sextet scalar at the LHC. We focus on the QCD production of a color sextet pair Φ6Φ̅ 6 through gg fusion and qq̅ annihilation. Its unique coupling to ψ̅ cψ allows the color sextet scalar to decay into same-sign diquark states, such as Φ6→tt/tt*. We propose a new reconstruction in the multijet plus same-sign dilepton with missing transverse energy samples (bb+ℓ±ℓ±+E̸T+Nj, N≥6) to search for on-shell ttt̅ t̅ final states from sextet scalar pair production. Thanks to the large QCD production, the search covers the sextet mass range up to 1 TeV for 100 fb-1 integrated luminosity.
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| 3. |
- Heck, J., et al.
(författare)
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Structure-property relationship in organometallic compounds regarding SHG
- 2007
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Ingår i: Linear and Nonlinear Optics of Organic Materials VII. - : SPIE - International Society for Optical Engineering. - 9780819468017 ; , s. R6530-R6530
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Konferensbidrag (refereegranskat)abstract
- Structure-property relationships based on experimental as well as theoretical results will be elucidated. For this purpose different dipolar organometallic compounds were synthesized and characterized. The alteration of the donor and acceptor termini in mono- and dinuclear sesquifulvalene complexes results in spectroscopic and even structural modifications. The structural and 1H NMR spectroscopic changes correlate with the experimentally obtained first hyperpolarizability. The potent electron-donating (D) group [(CpFeCO)2(μ-CO)(μ-C=CH-)] is combined with different electron-accepting units (A), yielding the push-pull complexes [(CpFeCO) 2(μ-CO)(μ-C=CH-CH=A)]. The extent of electron derealization within the π-bridge connecting the donor D and the acceptor A can be monitored by means of 1H NMR spectroscopy. A correlation between the 3J(Hβ-Hγ) coupling constants and the first hyperpolarizability is found, which very much resembles the dependence of the first hyperpolarizability on the bond length alternation. In order to elucidate the dependence of the NLO response on the conformation of triply branched NLOphores, a new series of dendritic D-π-A structures has been synthesized. A combined approach of experiments and computational predictions was applied both on the dendrimers and on the corresponding single-strand chromophores. These results demonstrate that theoretical calculations are able to reproduce experimental results and show the tendency of the effects due to structural changes.
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| 4. |
- Holtmann, J., et al.
(författare)
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Three-branched dendritic dipolar nonlinear optical chromophores, more than three times a single-strand chromophore?
- 2008
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Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 112:47, s. 14751-14761
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Tidskriftsartikel (refereegranskat)abstract
- To elucidate the dependence of the nonlinear optical (NLO) response on the conformation of triply branched derivatives, a new series of D-pi-A dendrimers has been synthesized. A combined approach of experiments (UV-vis and EOA measurements) and computational predictions (semiempirical and ab initio) was applied both on the dendrimers and on the corresponding single-strand chromophores. It has been shown that depending on the surrounding media the NLO activity of a flexible dendrimer can be very different. Two limiting cases are proposed: (i) the dendrimer resembles a solution of the corresponding single-strand chromophores with about 3-fold concentration, where the hyperpolarizability is the sum of the effect of three noninteracting single-strand subunits ("independent chromophores" limit); (ii) the dendrimers show nearly parallel or helical alignments of the single-strand subunits. Because of this change of conformation the NLO activity can be enhanced up to nine times the value of the "independent chromophores" limit and, thus, are more than a single strand chromophore. Conformers of dendrimers with interacting single-strand chromophores have been identified experimentally in nonpolar solutions by the EOA spectroscopy and possible structures have been revealed by numerical calculations, which could moreover show the tendency of the effects on the hyperpolarizability due to structural changes of the flexible dendritic architecture. Implications for future research developments are given to implement the "more than three times" concept.
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| 5. |
- Liu, Kai, et al.
(författare)
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Aggregation effects on two-photon absorption spectra of octupolar molecules
- 2007
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Ingår i: Journal of Chemical Physics. - : AIP Publishing. - 0021-9606 .- 1089-7690. ; 127:2, s. 026101-
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Tidskriftsartikel (refereegranskat)abstract
- Aggregation effects on two-photon absorption cross sections of an octupolar molecule, 1,3,5-triamino-2,4,6-trinitrobenzene, have been examined by means of density functional theory calculations in combination with molecular dynamic simulations. It is shown that this octupolar molecule becomes polar in solution and forms aggregates due to the presence of hydrogen bonding between molecules, which can induce a strong redshift of the charge-transfer state and significantly alter the TPA cross section.
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| 6. |
- Liu, Kai, et al.
(författare)
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Origin of the Q-band splitting in the absorption spectra of aluminum phthalocyanine chloride
- 2007
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Ingår i: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 438:1-3, s. 36-40
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Tidskriftsartikel (refereegranskat)abstract
- The Q-band of aluminum phthalocyanine chloride (AlPcCl) shows experimentally distinct splitting in the aqueous solution. Time-dependent density functional theory calculations with inclusion of polarizable continuum model have been performed to reveal the origin of this splitting. It is found that the spectral splitting caused by the formation of dimers and interaction with two water molecules are much smaller than what was predicted by previous semi-empirical study. Our calculations indicate that the experimentally observed large Q-band splitting can be explained by considering the geometrical distortions that are associated with changes of bonds between carbon and nitrogen atoms.
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| 7. |
- Liu, Kai, et al.
(författare)
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Two-photon absorption of hydrogen-bonded octupolar molecule clusters
- 2008
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Ingår i: Journal of Physical Chemistry B. - : American Chemical Society (ACS). - 1520-6106 .- 1520-5207. ; 112:14, s. 4387-4392
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Tidskriftsartikel (refereegranskat)abstract
- Charge-transfer octupolar molecules can form clusters in solution through intermolecular hydrogen bonds. In the present work we explore the role of such clustering on two-photon absorption (TPA) spectra assuming 1,3,5-triamino-2,4,6- trinitrobenzene (TATB) as a model system. Using density functional quadratic response theory we examine different cluster structures of TATB dimers, trimers, and tetramers taken from snapshots of molecular dynamics simulations. In comparison with the TPA spectrum of a monomer, significant red shifts of charge-transfer states are predicted for all chosen clusters, which mainly is the result of the distortion of the structures induced by the aggregation. The TPA spectra for dimers and trimers show strong conformation dependence, whereas they turn out to be more stable for tetramers. Enhancements of TPA absorption have also been found for clusters containing less distorted molecules connected by hydrogen bonds.
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| 8. |
- Wang, Yu, et al.
(författare)
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Dynamic TDM Virtual Circuit Implementation for NoCs
- 2008
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Ingår i: Proceedings of Asia-Pacific Conference on Circuits and Systems (APCCAS’08). - 9781424423422 ; , s. 1533-1536
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Konferensbidrag (refereegranskat)abstract
- Quality-of-Service (QoS) communication has been a key issue since the birth of Network-on-Chip (NoC). Time Division Multiplexing (TDM) techniques are well-recognized to be capable of providing guarantees in latency and bandwidth. However, current TDM VC proposals assume synchronous operation and use a costly slot allocation table to statically allocate bandwidth. In this paper, we propose a novel TDM VC implementation that releases the strict synchronous operation assumption and computes slot allocation fully dynamically. To promise VC contention-free, we use the Logical Network theory to guide the slot computation. The slot allocation information is computed once and propagated downstream. This enables adaptive VC configuration and also allows us to use smaller allocation tables in routers. We describe our dynamic TDM VC implementation mechanism, and detail the router design to support this mechanism.
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| 9. |
- Yeager, Meredith, et al.
(författare)
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Identification of a new prostate cancer susceptibility locus on chromosome 8q24.
- 2009
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Ingår i: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:10, s. 1055-7
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Tidskriftsartikel (refereegranskat)abstract
- We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.
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