| 3. |
- Kulatilake, P.H.S.W., et al.
(författare)
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Use of the distinct element method to perform stress analysis in rock with non-persistent joints and to study the effect of joint geometry parameters on the strength and deformability of rock masses
- 1992
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Ingår i: Rock Mechanics and Rock Engineering. - 0723-2632 .- 1434-453X. ; 25:4, s. 253-274
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Tidskriftsartikel (refereegranskat)abstract
- To use the distinct element method, it is necessary to discretize the problem domain into polygons in two dimensions (2 D) or into polyhedra in three dimensions (3 D). To perform distinct element stress analysis in a rock mass which contains non-persistent finite size joints, it is necessary to generate some type of fictitious joints so that when they are combined with the non-persistent joints, they discretize the problem domain into polygons in 2 D or into polyhedra in 3 D. The question arises as to which deformation and strength parameter values should be assigned to these fictitious joints so that they behave as intact rock. In this paper, linear elastic, perfectly-plastic constitutive models with the Mohr-Coulomb failure criterion, including a tension cut-off, were used to represent the mechanical behaviour of both intact rock and fictitious joints. It was found that, by choosing the parameter values for the constitutive models as given below, it is possible to make the fictitious joints behave as intact rock, in a global sense
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| 4. |
- Wang, Y, et al.
(författare)
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Functional homology between N-myc and c-myc in murine plasmacytomagenesis : plasmacytoma development in N-myc transgenic mice
- 1992
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Ingår i: Oncogene. - 0950-9232. ; 7:6, s. 7-1241
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Tidskriftsartikel (refereegranskat)abstract
- Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., Weber, G., Babonits, M., Rosen, A., Wiener, F. & Klein, G. (1990). Int. J. Cancer, 46, 845-852]. In order to test whether another member of the myc family, N-myc, could play a similar role as c-myc, we treated E mu-N-myc transgenic mice with pristane and helper-free A-MuLV. Of 20 mice that received a single pristane injection followed by A-MuLV, 17 developed plasmacytomas with a mean latency period of 54 +/- 20 days. In a corresponding group that only received a single pristane injection, five out of six transgenic mice developed plasmacytomas with a mean latency period of 142 +/- 32 days. However, after three monthly injections of pristane, all 15 transgenic mice developed plasmacytomas with a mean latency period of 128 +/- 20 days. All plasmacytomas expressed the N-myc transgene, while none of them expressed either c-myc or endogenous N-myc. None of the tumors carried the usual plasmacytoma-associated translocations.
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