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The molecular genet...
The molecular genetic landscape of human brain size variation
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- Seidlitz, Jakob (författare)
- The Children's Hospital of Philadelphia,University of Pennsylvania
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- Mallard, Travis T. (författare)
- Massachusetts General Hospital,Harvard Medical School,Broad Institute
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- Vogel, Jacob W. (författare)
- University of Pennsylvania
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visa fler...
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- Lee, Younga H. (författare)
- Broad Institute,Massachusetts General Hospital,Harvard Medical School
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- Warrier, Varun (författare)
- University of Cambridge
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- Ball, Gareth (författare)
- Murdoch Children's Research Institute,University of Melbourne
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- Hansson, Oskar (författare)
- Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,LU profilområde: Proaktivt åldrande,Lunds universitets profilområden,Clinical Memory Research,Lund University Research Groups,LU Profile Area: Proactive Ageing,Lund University Profile areas,Skåne University Hospital,Skåne University Hospital: Memory Clinic (MemoryHealth)
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- Hernandez, Leanna M. (författare)
- University of California, Los Angeles
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- Mandal, Ayan S. (författare)
- University of Pennsylvania,The Children's Hospital of Philadelphia
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- Wagstyl, Konrad (författare)
- Wellcome Trust Centre for Neuroimaging, London
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- Lombardo, Michael V. (författare)
- Italian Institute of Technology
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- Courchesne, Eric (författare)
- University of California, San Diego
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- Glessner, Joseph T. (författare)
- The Children's Hospital of Philadelphia,University of Pennsylvania
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- Satterthwaite, Theodore D. (författare)
- The Children's Hospital of Philadelphia,University of Pennsylvania
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- Bethlehem, Richard A.I. (författare)
- University of Cambridge
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- Bernstock, Joshua D. (författare)
- Harvard University,Massachusetts Institute of Technology
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- Tasaki, Shinya (författare)
- Rush Alzheimer's Disease Center
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- Ng, Bernard (författare)
- Rush Alzheimer's Disease Center
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- Gaiteri, Chris (författare)
- Rush Alzheimer's Disease Center
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- Smoller, Jordan W. (författare)
- Harvard Medical School,Massachusetts General Hospital,Broad Institute
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- Ge, Tian (författare)
- Broad Institute,Harvard Medical School,Massachusetts General Hospital
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- Gur, Raquel E. (författare)
- University of Pennsylvania,The Children's Hospital of Philadelphia
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- Gandal, Michael J. (författare)
- The Children's Hospital of Philadelphia,University of Pennsylvania
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- Alexander-Bloch, A. F. (författare)
- The Children's Hospital of Philadelphia,University of Pennsylvania
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(creator_code:org_t)
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- 2023
- 2023
- Engelska.
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Ingår i: Cell Reports. - 2211-1247. ; 42:11
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Human brain size changes dynamically through early development, peaks in adolescence, and varies up to 2-fold among adults. However, the molecular genetic underpinnings of interindividual variation in brain size remain unknown. Here, we leveraged postmortem brain RNA sequencing and measurements of brain weight (BW) in 2,531 individuals across three independent datasets to identify 928 genome-wide significant associations with BW. Genes associated with higher or lower BW showed distinct neurodevelopmental trajectories and spatial patterns that mapped onto functional and cellular axes of brain organization. Expression of BW genes was predictive of interspecies differences in brain size, and bioinformatic annotation revealed enrichment for neurogenesis and cell-cell communication. Genome-wide, transcriptome-wide, and phenome-wide association analyses linked BW gene sets to neuroimaging measurements of brain size and brain-related clinical traits. Cumulatively, these results represent a major step toward delineating the molecular pathways underlying human brain size variation in health and disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- brain development
- CP: Neuroscience
- imaging genetics
- psychiatric disorders
- transcriptomics
- TWAS
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Seidlitz, Jakob
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Mallard, Travis ...
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Vogel, Jacob W.
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Lee, Younga H.
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Warrier, Varun
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Ball, Gareth
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visa fler...
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Hansson, Oskar
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Hernandez, Leann ...
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Mandal, Ayan S.
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Wagstyl, Konrad
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Lombardo, Michae ...
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Courchesne, Eric
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Glessner, Joseph ...
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Satterthwaite, T ...
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Bethlehem, Richa ...
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Bernstock, Joshu ...
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Tasaki, Shinya
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Ng, Bernard
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Gaiteri, Chris
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Smoller, Jordan ...
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Ge, Tian
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Gur, Raquel E.
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Gandal, Michael ...
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Alexander-Bloch, ...
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