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Natural IgM antibodies in the immune defence against neoehrlichiosis

Wennerås, Christine, 1963 (författare)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis & Hematol, Gothenburg, Sweden.,Department of Infectious Diseases and Hematology , Sahlgrenska Academy, University of Gothenburg , Göteborg , Sweden
Goldblatt, D. (författare)
UCL, Great Ormond St Inst Child Hlth, Immunobiol Sect, London, England.,Immunobiology Section , Great Ormond Street Institute of Child Health, University College London , London , UK
Zancolli, M. (författare)
UCL, Great Ormond St Inst Child Hlth, Immunobiol Sect, London, England.,Immunobiology Section , Great Ormond Street Institute of Child Health, University College London , London , UK
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Mattsson, Mattias (författare)
Uppsala universitet,Experimentell och klinisk onkologi,Hematologi,Department of Hematology , Uppsala University Hospital , Uppsala , Sweden
Wass, Linda (författare)
Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Univ Gothenburg, Sahlgrenska Acad, Dept Infect Dis & Hematol, Gothenburg, Sweden.,Department of Infectious Diseases and Hematology , Sahlgrenska Academy, University of Gothenburg , Göteborg , Sweden
Horkko, S. (författare)
Univ Oulu, Med Res Ctr, Dept Med Microbiol & Immunol, Oulu, Finland.;Oulu Univ Hosp, Nordlab Oulu, Oulu, Finland.,Department of Medical Microbiology and Immunology , Medical Research Center University of Oulu, and Nordlab Oulu, Oulu University Hospital , Oulu , Finland
Rosén, Anders (författare)
Linköpings universitet,Medicinska fakulteten,Avdelningen för cellbiologi
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 (creator_code:org_t)
2017-07-06
2017
Engelska.
Ingår i: Infectious Diseases. - : Informa UK Limited. - 2374-4235 .- 2374-4243. ; 49:11-12, s. 809-816
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: Neoehrlichiosis is an infectious disease caused by the tick-borne bacterium Candidatus Neoehrlichia mikurensis. Splenectomy and rituximab therapies are risk factors for severe neoehrlichiosis. Our aim was to examine if neoehrlichiosis patients had low levels of natural IgM antibodies and/or were hypogammaglobulinemic, and if such deficiencies were associated with asplenia and vascular complications. Methods: Neoehrlichiosis patients (n=9) and control subjects (n=10) were investigated for serum levels of IgG, IgA, and IgM, and for levels of natural IgM antibodies to pneumococcal polysaccharides (6B, 14), and to the malondialdehyde acetaldehyde epitope of oxidized LDL. The multivariate method Projection to Latent Structures was used to analyze the data. Results: The levels of natural IgM antibodies of various specificities were decreased or not measurable in half of the studied patients with neoehrlichiosis. Only one patient and one control subject were hypogammaglobulinemic. An inverse relationship was noted between the levels of natural IgM antibodies and the development of deep vein thrombosis. Unexpectedly, no association was seen between having or not having a spleen and the levels of natural IgM antibody levels in the circulation. Conclusions: Neither hypogammaglobulinemia nor lack of natural IgM antibodies alone predisposes for severe neoehrlichiosis. The importance of the spleen in the immune defence against Ca. N. mikurensis probably lies in its capacity to generate or maintain specific antibodies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

Candidatus Neoehrlichia mikurensis
natural IgM antibodies
malondialdehyde acetaldehyde epitope
memory b-cells
malondialdehyde acetaldehyde adducts
chronic
lymphocytic-leukemia
apoptotic cells
mikurensis
infections
rituximab
immunoglobulin
disease
spleen
Infectious Diseases
Candidatus Neoehrlichia mikurensis

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