Sökning: WFRF:(Wasserstrom Sebastian)
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Bioactive Suture wi...
Bioactive Suture with Added Innate Defense Functionality for the Reduction of Bacterial Infection and Inflammation
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- Puthia, Manoj (författare)
- Lund University,Lunds universitet,Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG,Institutionen för laboratoriemedicin,Medicinska fakulteten,Schmidtchen lab,Forskargrupper vid Lunds universitet,Division of Microbiology, Immunology and Glycobiology - MIG,Department of Laboratory Medicine,Faculty of Medicine,Schmidtchen Lab,Lund University Research Groups,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Petrlova, Jitka (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Schmidtchen lab,Forskargrupper vid Lunds universitet,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Schmidtchen Lab,Lund University Research Groups,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Petruk, Ganna (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Butrym, Marta (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Samsudin, Firdaus (författare)
- Bioinformatics Institute (BII) Agency for Science Technology and Research (A*STAR) Singapore 138671 Singapore
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- Andersson, Madeleine Å (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Strömdahl, Ann-Charlotte (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Schmidtchen lab,Forskargrupper vid Lunds universitet,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Schmidtchen Lab,Lund University Research Groups,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Wasserstrom, Sebastian (författare)
- Lund University,Lunds universitet,Glukostransport och proteintrafficking,Forskargrupper vid Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Glucose Transport and Protein Trafficking,Lund University Research Groups,Faculty of Medicine,Lund University Bioimaging Centre Lund University Lund SE‐22184 Sweden
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- Hartman, Erik (författare)
- Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Kjellström, Sven (författare)
- Lund University,Lunds universitet,Masspektrometri,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,BioMS,Forskargrupper vid Lunds universitet,Mass Spectrometry,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Division of Mass Spectrometry Department of Clinical Sciences Lund University Lund SE‐22184 Sweden
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- Caselli, Lucrezia (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Physical Chemistry 1 Lund University Lund S‐221 00 Sweden
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- Klementieva, Oxana (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Medicinsk mikrospektroskopi,Forskargrupper vid Lunds universitet,LINXS - Institute of advanced Neutron and X-ray Science,Kemiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,LU profilområde: Ljus och material,Lunds universitets profilområden,LU profilområde: Proaktivt åldrande,Other operations, LTH,Faculty of Engineering, LTH,Medical Microspectroscopy,Lund University Research Groups,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH,LU Profile Area: Light and Materials,Lund University Profile areas,LU Profile Area: Proactive Ageing,Medical Microspectroscopy Lab Department of Experimental Medical Sciences Faculty of Medicine Lund University Lund SE‐221 84 Sweden
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- Bond, Peter J. (författare)
- Bioinformatics Institute (BII) Agency for Science Technology and Research (A*STAR) Singapore 138671 Singapore;Department of Biological Sciences National University of Singapore Singapore 117543 Singapore
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- Malmsten, Martin (författare)
- Lund University,Lunds universitet,Fysikalisk kemi,Enheten för fysikalisk och teoretisk kemi,Kemiska institutionen,Institutioner vid LTH,Lunds Tekniska Högskola,Physical Chemistry,Physical and theoretical chemistry,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,Physical Chemistry 1 Lund University Lund S‐221 00 Sweden;Department of Pharmacy University of Copenhagen Copenhagen DK‐2100 Denmark
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- Raina, Deepak (författare)
- Lund University,Lunds universitet,Ortopedi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Building Bone Killing Bugs,Forskargrupper vid Lunds universitet,Klinisk och experimentell benläkning,Orthopaedics (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,Clinical and experimental bone healing,Department of Clinical Sciences Lund Orthopedics Faculty of Medicine Lund University Lund SE‐221 84 Sweden
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- Schmidtchen, Artur (författare)
- Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Schmidtchen lab,Forskargrupper vid Lunds universitet,LU profilområde: Ljus och material,Lunds universitets profilområden,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Schmidtchen Lab,Lund University Research Groups,LU Profile Area: Light and Materials,Lund University Profile areas,Division of Dermatology and Venereology Department of Clinical Sciences Lund University Lund SE‐22184 Sweden;Dermatology Skane University Hospital Lund SE‐22185 Sweden
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(creator_code:org_t)
- Wiley, 2023
- 2023
- Engelska.
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Ingår i: Advanced Healthcare Materials. - : Wiley. - 2192-2640 .- 2192-2659. ; 12:31, s. 1-20
- Relaterad länk:
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https://mau.diva-por... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Surgical site infections (SSI) are a clinical and economic burden. Suture-associated SSI may develop when bacteria colonize the suture surface and form biofilms that are resistant to antibiotics. Thrombin-derived C-terminal peptide (TCP)-25 is a host defense peptide with a unique dual mode of action that can target both bacteria and the excessive inflammation induced by bacterial products. The peptide demonstrates therapeutic potential in preclinical in vivo wound infection models. In this study, the authors set out to explore whether TCP-25 can provide a new bioactive innate immune feature to hydrophilic polyglactin sutures (Vicryl). Using a combination of biochemical, biophysical, antibacterial, biofilm, and anti-inflammatory assays in vitro, in silico molecular modeling studies, along with experimental infection and inflammation models in mice, a proof-of-concept that TCP-25 can provide Vicryl sutures with a previously undisclosed host defense capacity, that enables targeting of bacteria, biofilms, and the accompanying inflammatory response, is shown.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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Puthia, Manoj
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Petrlova, Jitka
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Petruk, Ganna
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Butrym, Marta
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Samsudin, Firdau ...
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Andersson, Madel ...
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visa fler...
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Strömdahl, Ann-C ...
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Wasserstrom, Seb ...
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Hartman, Erik
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Kjellström, Sven
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Caselli, Lucrezi ...
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Klementieva, Oxa ...
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Bond, Peter J.
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Malmsten, Martin
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Raina, Deepak
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Schmidtchen, Art ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinsk biotek ...
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och Biomaterialveten ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Infektionsmedici ...
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Advanced Healthc ...
- Av lärosätet
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Malmö universitet
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Lunds universitet