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The involvement of ...
The involvement of spinal release of histamine on nociceptive behaviors induced by intrathecally administered spermine
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- Mizoguchi, Hirokazu (författare)
- Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan.
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- Watanabe, Chizuko (författare)
- Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan.
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- Hayashi, Takafumi (författare)
- Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Pharmaceut Sci, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan.
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- Iwata, Yoko (författare)
- Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan.
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- Watanabe, Hiroyuki (författare)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap
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- Katsuyama, Soh (författare)
- Tokyo Univ Pharm & Life Sci, Ctr Experiential Pharm Practice, Sch Pharm, 1432-1 Horinouchi, Hachioji, Tokyo 1920392, Japan.
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- Hamamura, Kengo (författare)
- Daiichi Coll Pharmaceut Sci, Dept Pharmacol 1, Minami Ku, 22-1 Tamagawa Cho, Fukuoka 8158511, Japan.
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- Sakurada, Tsukasa (författare)
- Daiichi Coll Pharmaceut Sci, Dept Pharmacol 1, Minami Ku, 22-1 Tamagawa Cho, Fukuoka 8158511, Japan.
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- Ohtsu, Hiroshi (författare)
- Tohoku Univ, Grad Sch Engn, Dept Quantum Sci & Energy Engn, Aoba Ku, 6-6-01-2 Aobayama, Sendai, Miyagi 9808579, Japan.
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- Yanai, Kazuhiko (författare)
- Tohoku Univ, Grad Sch Med, Dept Pharmacol, Aoba Ku, 2-1 Seiryo Machi, Sendai, Miyagi 9808575, Japan.
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- Sakurada, Shinobu (författare)
- Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan.
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Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Physiol & Anat, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan Tohoku Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Pharmaceut Sci, Aoba Ku, 4-4-1 Komatsushima, Sendai, Miyagi 9818558, Japan. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- Engelska.
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Ingår i: European Journal of Pharmacology. - : Elsevier BV. - 0014-2999 .- 1879-0712. ; 800, s. 9-15
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The involvement of spinal release of histamine on nociceptive behaviors induced by spermine was examined in mice. Intrathecal spermine produced dose-dependent nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by spermine at 0.02 amol and 10 pmol were markedly suppressed by i.t. pretreatment with antiserum against histamine and were abolished in histidine decarboxylase-deficient mice. In histamine H-1 receptor-deficient mice, the nociceptive behaviors induced by spermine were completely abolished after treatment with 0.02 amol of spermine and significantly suppressed after treatment with 10 pmol of spermine. The i.t. pretreatment with takykinin NK1 receptor antagonists eliminated the nociceptive behaviors induced by 0.02 amol of spermine, but did not affect the nociceptive behaviors induced by 10 pmol of spermine. On the other hand, the nociceptive behaviors induced by spermine at both 0.02 amol and 10 pmol were suppressed by i.t. pretreatment with antagonists for the NMDA receptor polyamine-binding site. The present results suggest that the nociceptive behaviors induced by i.t. administration of spermine are mediated through the spinal release of histamine and are elicited via activation of NMDA receptors.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Nyckelord
- Spermine
- Histamine
- Release
- NMDA receptor
- Nociception
- Spinal cord
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Mizoguchi, Hirok ...
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Watanabe, Chizuk ...
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Hayashi, Takafum ...
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Iwata, Yoko
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Watanabe, Hiroyu ...
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Katsuyama, Soh
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Hamamura, Kengo
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Sakurada, Tsukas ...
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Ohtsu, Hiroshi
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Yanai, Kazuhiko
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Sakurada, Shinob ...
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Uppsala universitet