1. |
|
|
2. |
|
|
3. |
- Antoni, Gunnar, et al.
(författare)
-
Synthesis of l-2,4-Diamino[4-11C]butyric acid and its use in some In vitro and In vivo tumour models
- 1997
-
Ingår i: Nuclear Medicine and Biology. - 0969-8051 .- 1872-9614. ; 24:6, s. 595-601
-
Tidskriftsartikel (refereegranskat)abstract
- l-2,4-Diamino[4-11C]butyric acid (DAB) was synthesized by an enzyme catalysed carrier added (0.1 μmol KCN) reaction of hydrogen [11C]cyanide with O-acetyl-l-serine followed by reduction. l-[11C]DAB was obtained with a radiochemical purity higher than 96% and with a decay corrected radiochemical yield of 30–40% within a 32 min reaction time. The enantiomeric excess was 98%. The uptake of l-[11C]DAB was investigated in multicellular aggregates of six different cell lines and animal tumour models. l-[11C]DAB is potentially useful for the assessment of pharmacokinetics of l-DAB in vivo for part of its evaluation as an antitumoural agent, although its use for diagnostic purposes seems limited.
|
|
4. |
- Bjorkman, M, et al.
(författare)
-
Synthesis of C-11/C-13-labelled prostacyclins
- 1998
-
Ingår i: ACTA CHEMICA SCANDINAVICA. - : MUNKSGAARD INT PUBL LTD. ; 52:5
-
Annan publikation (övrigt vetenskapligt/konstnärligt)abstract
- A one-pot synthesis of (15R)-16-(3-[C-11]methylphenyl)-17,18,19,20-tetranorisocarbacyclin methyl ester was performed using a palladium-promoted reaction of [C-11]methyl iodide with ( 15R)-16-(3-tri-n-butylstannylphenyl)-17,18,19,20,-tetranorisocarbacycli
|
|
5. |
|
|
6. |
|
|
7. |
|
|
8. |
|
|
9. |
|
|
10. |
|
|